Yuning J. Tang
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View article: Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression
Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression Open
Most cancers are diagnosed in people over 60 years of age, but little is known about how age impacts tumorigenesis. While aging is accompanied by mutation accumulation (widely understood to contribute to cancer risk) it is associated with …
View article: Tumor-colonizing <i>Pseudoalteromonas elyakovii</i> metabolically reprograms the tumor microenvironment and promotes breast ductal carcinoma
Tumor-colonizing <i>Pseudoalteromonas elyakovii</i> metabolically reprograms the tumor microenvironment and promotes breast ductal carcinoma Open
The correlation between the microbiota found in tumors and tumor development is being progressively understood, specifically regarding its involvement in the initiation and advancement of tumors. We examined a total of 102 samples, examini…
View article: Combinatorial In Vivo Genome Editing Identifies Widespread Epistasis and an Accessible Fitness Landscape During Lung Tumorigenesis
Combinatorial In Vivo Genome Editing Identifies Widespread Epistasis and an Accessible Fitness Landscape During Lung Tumorigenesis Open
Lung adenocarcinoma, the most common subtype of lung cancer, is genomically complex, with tumors containing tens to hundreds of non-synonymous mutations. However, little is understood about how genes interact with each other to enable the …
View article: Kinetic analysis of PODE1–3 combustion mechanisms: towards a general framework for reaction pathways
Kinetic analysis of PODE1–3 combustion mechanisms: towards a general framework for reaction pathways Open
Polyoxymethylene dimethyl ethers (PODEs) have emerged as promising clean alternative fuels for compression-ignition engines. The combustion characteristics of PODE vary with the degree of polymerization, necessitating a deeper understandin…
View article: A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis Open
The cohesin complex is a critical regulator of gene expression. STAG2 is the most frequently mutated cohesin subunit across several cancer types and is a key tumor suppressor in lung cancer. Here, we coupled somatic CRISPR-Cas9 genome edit…
View article: A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis Open
The cohesin complex is a critical regulator of gene expression. STAG2 is the most frequently mutated cohesin subunit across several cancer types and is a key tumor suppressor in lung cancer. Here, we coupled somatic CRISPR-Cas9 genome edit…
View article: Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network
Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network Open
TP53 , the most frequently mutated gene in human cancer, encodes a transcriptional activator that induces myriad downstream target genes. Despite the importance of p53 in tumor suppression, the specific p53 target genes important for tumor…
View article: Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes
Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes Open
Epigenetic dysregulation is widespread in cancer. However, the specific epigenetic regulators and the processes they control to drive cancer phenotypes are poorly understood. Here, we employed a novel, scalable and high-throughput in vivo …
View article: Aging represses lung tumorigenesis and alters tumor suppression
Aging represses lung tumorigenesis and alters tumor suppression Open
Most cancers are diagnosed in persons over the age of sixty, but little is known about how age impacts tumorigenesis. While aging is accompanied by mutation accumulation — widely understood to contribute to cancer risk — it is also associa…
View article: Combinatorial<i>in vivo</i>genome editing identifies widespread epistasis during lung tumorigenesis
Combinatorial<i>in vivo</i>genome editing identifies widespread epistasis during lung tumorigenesis Open
Lung adenocarcinoma, the most common subtype of lung cancer, is genomically complex, with tumors containing tens to hundreds of non-synonymous mutations. However, little is understood about how genes interact with each other to enable tumo…
View article: Efficient and multiplexed somatic genome editing with Cas12a mice
Efficient and multiplexed somatic genome editing with Cas12a mice Open
Somatic genome editing in mouse models has increased our understanding of the in vivo effects of genetic alterations in areas ranging from neuroscience to cancer biology and beyond. However, existing models are limited in their ability to …
View article: Methylation and transcriptomic expression profiles of HUVEC in the oxygen and glucose deprivation model and its clinical implications in AMI patients
Methylation and transcriptomic expression profiles of HUVEC in the oxygen and glucose deprivation model and its clinical implications in AMI patients Open
The obstructed coronary artery undergoes a series of pathological changes due to ischemic-hypoxic shocks during acute myocardial infarction (AMI). However, the altered DNA methylation levels in endothelial cells under these conditions and …
View article: Role of DNA Methylation in Ischemic-Hypoxic Endothelial Cells and its Clinical Implications in AMI Patients
Role of DNA Methylation in Ischemic-Hypoxic Endothelial Cells and its Clinical Implications in AMI Patients Open
The obstructed coronary artery undergoes a series of pathological changes due to ischemia and hypoxic shocks during acute myocardial infarction (AMI). However, the altered DNA methylation levels in endothelial cells under these conditions …
View article: A Meta-Analysis of Application of Pd-1/Pd-L1 Inhibitor-Based Immunotherapy in Unresectable Locally Advanced Triple-Negative Breast Cancer
A Meta-Analysis of Application of Pd-1/Pd-L1 Inhibitor-Based Immunotherapy in Unresectable Locally Advanced Triple-Negative Breast Cancer Open
Aims: The purpose of this study was to explore the efficacy of immunotherapy for patients with triple-negative breast cancer (TNBC). Materials & methods: Randomized clinical trials comparing immunotherapy with chemotherapy for advanced TNB…
View article: High-Throughput Identification, Modeling, and Analysis of Cancer Driver Genes In Vivo
High-Throughput Identification, Modeling, and Analysis of Cancer Driver Genes In Vivo Open
The vast number of genomic and molecular alterations in cancer pose a substantial challenge to uncovering the mechanisms of tumorigenesis and identifying therapeutic targets. High-throughput functional genomic methods in genetically engine…
View article: Prevalence of anxiety, depressive and insomnia symptoms among the different groups of people during COVID-19 pandemic: An overview of systematic reviews and meta-analyses
Prevalence of anxiety, depressive and insomnia symptoms among the different groups of people during COVID-19 pandemic: An overview of systematic reviews and meta-analyses Open
Since the pandemic of the novel 2019 coronavirus disease (COVID-19), in addition to the harm caused by the disease itself, the psychological damage caused to the public by the pandemic is also a serious problem. The aim of our study was to…
View article: Tumor-propagating side population cells are a dynamic subpopulation in undifferentiated pleomorphic sarcoma
Tumor-propagating side population cells are a dynamic subpopulation in undifferentiated pleomorphic sarcoma Open
Sarcomas contain a subpopulation of tumor-propagating cells (TPCs) with enhanced tumor-initiating and self-renewal properties. However, it is unclear whether the TPC phenotype in sarcomas is stable or a dynamic cell state that can derive f…
View article: Distinct roles of glutamine metabolism in benign and malignant cartilage tumors with <i>IDH</i> mutations
Distinct roles of glutamine metabolism in benign and malignant cartilage tumors with <i>IDH</i> mutations Open
Enchondromas and chondrosarcomas are common cartilage neoplasms that are either benign or malignant respectively. The majority of these tumors harbor mutations in either IDH1 or IDH2. Glutamine metabolism has been implicated as a critical …
View article: Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations
Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations Open
Enchondromas and chondrosarcomas are common cartilage neoplasms that are either benign or malignant, respectively. The majority of these tumors harbor mutations in either IDH1 or IDH2. Glutamine metabolism has been implicated as a critical…
View article: The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice
The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice Open
Skeletal stem/progenitor cells (SSPC) are critical regulators of bone homeostasis by providing a continuous supply of osteoblasts throughout life. In response to inductive signals, SSPC proliferate before osteoblast differentiation. Prolif…
View article: Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma
Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma Open
Enchondroma and chondrosarcoma are the most common benign and malignant cartilaginous neoplasms. Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are present in the majority of these tumors. We performed RNA-seq analysis on chondrocy…
View article: Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis Open
During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here we investigated conditional deletion of Scap or Insig1 and Insig2 (inhibits or activates intracellula…
View article: Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma
Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma Open
Tumor-propagating cells (TPCs) are believed to drive cancer initiation, progression and recurrence. These cells are characterized by enhanced tumorigenicity and self-renewal. The ability to identify such cells in primary human sarcomas rel…
View article: Mutant <i>IDH</i> is sufficient to initiate enchondromatosis in mice
Mutant <i>IDH</i> is sufficient to initiate enchondromatosis in mice Open
Significance Current genomic and biochemical analysis revealed mutations in isocitrate dehydrogenase ( IDH ) genes associated with several neoplasms and a novel enzymatic activity of IDH mutations to catalyze α-ketoglutarate to d -2-hydrox…