Yunjie Zhao
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View article: YOLO-DCPG: a lightweight architecture with dual-channel pooling gated attention for intensive small-target agricultural pest detection
YOLO-DCPG: a lightweight architecture with dual-channel pooling gated attention for intensive small-target agricultural pest detection Open
Accurate and rapid identification of agricultural pests is essential for intelligent pest monitoring. However, existing pest detection models often suffer from high parameter counts and computational complexity, limiting their deployment o…
View article: RNA regulation mechanisms study using physics-informed machine learning
RNA regulation mechanisms study using physics-informed machine learning Open
View article: Structural Comparison and Therapeutic Effects on Ulcerative Colitis of Fucoidan and Its Derivative from Saccharina japonica
Structural Comparison and Therapeutic Effects on Ulcerative Colitis of Fucoidan and Its Derivative from Saccharina japonica Open
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that can lead to intestinal complications and systemic risks, significantly increasing the likelihood of colorectal cancer in individuals with long-term illness. Fucoida…
View article: Advances in Methods for Accurate Prediction of RNA–Small Molecule Binding Sites: From Isolated to AI-Integrated Strategies
Advances in Methods for Accurate Prediction of RNA–Small Molecule Binding Sites: From Isolated to AI-Integrated Strategies Open
Predicting RNA–small molecule binding sites is essential for developing RNA-targeted drugs. Identifying these sites experimentally is often costly, making computational methods essential for drug discovery. While traditional approaches rel…
View article: GIWT-YOLO: an efficient multi-scale framework for real-time Scolytinae pests detection
GIWT-YOLO: an efficient multi-scale framework for real-time Scolytinae pests detection Open
The broad range of Scolytinae pests sizes and their subtle visual similarities, especially in smaller species, continue to challenge the accuracy of mainstream object detection models. To address these challenges, this paper proposes GIWT-…
View article: Structural Characterization of Dendrobium officinale Polysaccharides and Their Regulation Effect on Intestinal Microbiota During In Vitro Fermentation
Structural Characterization of Dendrobium officinale Polysaccharides and Their Regulation Effect on Intestinal Microbiota During In Vitro Fermentation Open
Polysaccharides derived from Dendrobium officinale have been demonstrated to exhibit metabolic regulatory properties. However, the correlation between their structure and function, particularly their mechanism of action through gut microbi…
View article: RNA-protein interaction prediction using network-guided deep learning
RNA-protein interaction prediction using network-guided deep learning Open
Accurate computational determination of RNA-protein interactions remains challenging, particularly when encountering unknown RNAs and proteins. The limited number of RNAs and their flexibility constrained the effectiveness of the deep-lear…
View article: Advances and Mechanisms of RNA–Ligand Interaction Predictions
Advances and Mechanisms of RNA–Ligand Interaction Predictions Open
The diversity and complexity of RNA include sequence, secondary structure, and tertiary structure characteristics. These elements are crucial for RNA’s specific recognition of other molecules. With advancements in biotechnology, RNA–ligand…
View article: Facile Synthesis and Biological Evaluation of [A]-Benzannulated Bodipy Derivatives as Novel Heavy-Atom-Free Photosensitizers for Photodynamic Anticancer Therapy
Facile Synthesis and Biological Evaluation of [A]-Benzannulated Bodipy Derivatives as Novel Heavy-Atom-Free Photosensitizers for Photodynamic Anticancer Therapy Open
View article: AI-integrated network for RNA complex structure and dynamic prediction
AI-integrated network for RNA complex structure and dynamic prediction Open
RNA complexes are essential components in many cellular processes. The functions of these complexes are linked to their tertiary structures, which are shaped by detailed interface information, such as binding sites, interface contact, and …
View article: Advances and Challenges in Scoring Functions for RNA–Protein Complex Structure Prediction
Advances and Challenges in Scoring Functions for RNA–Protein Complex Structure Prediction Open
RNA–protein complexes play a crucial role in cellular functions, providing insights into cellular mechanisms and potential therapeutic targets. However, experimental determination of these complex structures is often time-consuming and res…
View article: Author Correction: Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells
Author Correction: Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells Open
View article: Integrated modeling of protein and RNA
Integrated modeling of protein and RNA Open
His research is centered around network science and deep learning, particularly in the field of biomolecule mechanisms and interactions.
View article: Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells Open
View article: Deciphering principles of nucleosome interactions and impact of cancer-associated mutations from comprehensive interaction network analysis
Deciphering principles of nucleosome interactions and impact of cancer-associated mutations from comprehensive interaction network analysis Open
Nucleosomes represent hubs in chromatin organization and gene regulation and interact with a plethora of chromatin factors through different modes. In addition, alterations in histone proteins such as cancer mutations and post-translationa…
View article: The Study of Equity Valuation Based on Modified Ohlson Model: Case of BYD
The Study of Equity Valuation Based on Modified Ohlson Model: Case of BYD Open
New energy vehicle companies are at an early stage of development and have large differences in terms of technological development, market maturity and R&D costs. In this context, traditional valuation methods do not meet the requirements …
View article: Excitation generated preferential binding sites for ethane on porous carbon–copper porphyrin sorbents: ethane/ethylene adsorptive separation improved by light
Excitation generated preferential binding sites for ethane on porous carbon–copper porphyrin sorbents: ethane/ethylene adsorptive separation improved by light Open
For C 2 H 6 /C 2 H 4 adsorptive separation, utilizing the excited states of the sorbent to generate new adsorption sites for preferential binding of C 2 H 6 is proposed.
View article: A Low Molecular Weight Fucoidan with High Sulfation Has Anti-Obesity Activity Via Gut Microbiota Regulation
A Low Molecular Weight Fucoidan with High Sulfation Has Anti-Obesity Activity Via Gut Microbiota Regulation Open
View article: HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules
HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules Open
The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription elongation factor-b (P-TEFb) and induce the transcription of th…
View article: RNet: a network strategy to predict RNA binding preferences
RNet: a network strategy to predict RNA binding preferences Open
Determining the RNA binding preferences remains challenging because of the bottleneck of the binding interactions accompanied by subtle RNA flexibility. Typically, designing RNA inhibitors involves screening thousands of potential candidat…
View article: FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment
FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment Open
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of the central nervous system (CNS) that is characterized by myelin damage, followed by axonal and ultimately neuronal loss, which has been found to be associated with …
View article: Design, synthesis, and biological evaluation of 1,6-naphthyridine-2-one derivatives as novel FGFR4 inhibitors for the treatment of colorectal cancer
Design, synthesis, and biological evaluation of 1,6-naphthyridine-2-one derivatives as novel FGFR4 inhibitors for the treatment of colorectal cancer Open
View article: Targeting extracellular matrix through phytochemicals: a promising approach of multi-step actions on the treatment and prevention of cancer
Targeting extracellular matrix through phytochemicals: a promising approach of multi-step actions on the treatment and prevention of cancer Open
Extracellular matrix (ECM) plays a pivotal and dynamic role in the construction of tumor microenvironment (TME), becoming the focus in cancer research and treatment. Multiple cell signaling in ECM remodeling contribute to uncontrolled prol…
View article: Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway
Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway Open
View article: Dissolution changes in drug-amino acid/biotin co-amorphous systems: Decreased/increased dissolution during storage without recrystallization
Dissolution changes in drug-amino acid/biotin co-amorphous systems: Decreased/increased dissolution during storage without recrystallization Open
Co-amorphous systems have been proven to be a promising strategy to address the poor water solubility of poorly water-soluble drugs. Generally, the initial dissolution behaviors after co-amorphous system preparation and the potential recry…
View article: Study on the Spatial Structure and Drivers of Agricultural Carbon Emission Efficiency in Belt and Road Initiative Countries
Study on the Spatial Structure and Drivers of Agricultural Carbon Emission Efficiency in Belt and Road Initiative Countries Open
Agricultural carbon emissions are one of the major causes of global climate change. As some of the world’s largest agricultural producers and consumers, countries along the route of the Belt and Road initiative produce significant agricult…
View article: FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment
FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment Open
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of the central nervous system (CNS) that is characterized by myelin damage followed by axonal and ultimately neuronal loss, which has been found to be associated with m…
View article: Exploring unbinding mechanism of drugs from SERT via molecular dynamics simulation and its implication in antidepressants
Exploring unbinding mechanism of drugs from SERT via molecular dynamics simulation and its implication in antidepressants Open
The human serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft, which is an essential process that plays an important role in depression. In addition to natural substrate serotonin, SERT i…
View article: RPflex: A Coarse-Grained Network Model for RNA Pocket Flexibility Study
RPflex: A Coarse-Grained Network Model for RNA Pocket Flexibility Study Open
RNA regulates various biological processes, such as gene regulation, RNA splicing, and intracellular signal transduction. RNA’s conformational dynamics play crucial roles in performing its diverse functions. Thus, it is essential to explor…
View article: Methods and Applications in Proteins and RNAs
Methods and Applications in Proteins and RNAs Open
Proteins and RNAs are primary biomolecules that are involved in most biological processes [...]