Yunjun Ge
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View article: Inductive‐Associative Meta‐learning Pipeline with Human Cognitive Patterns for Unseen Drug‐Target Interaction Prediction
Inductive‐Associative Meta‐learning Pipeline with Human Cognitive Patterns for Unseen Drug‐Target Interaction Prediction Open
Significant differences in protein structures hinder the generalization of existing drug‐target interaction (DTI) models, which often rely heavily on pre‐learned binding principles or detailed annotations. In contrast, BioBridge designs an…
View article: Discovery of Yersinia LcrV as a novel biased agonist of formyl peptide receptor 1 to bi-directionally modulate intracellular kinases in triple-negative breast cancer
Discovery of Yersinia LcrV as a novel biased agonist of formyl peptide receptor 1 to bi-directionally modulate intracellular kinases in triple-negative breast cancer Open
G protein-coupled receptors (GPCRs) are significant drug targets, but their potential in cancer therapy remains underexplored. Conventional GPCR agonists or antagonists have shown limited effectiveness in cancer treatment, necessitating ne…
View article: Inductive-Associative Meta-learning Pipeline with Human Cognitive Patterns for Unseen Drug-Target Interaction Prediction
Inductive-Associative Meta-learning Pipeline with Human Cognitive Patterns for Unseen Drug-Target Interaction Prediction Open
Significant differences in protein structures hinder the generalization of existing drug-target interaction (DTI) models, which often rely heavily on pre-learned binding principles or detailed annotations. In contrast, BioBridge designs an…
View article: Nebivolol-induced bi-directional modulation of intracellular kinases contributes to the inhibition of triple-negative breast cancer
Nebivolol-induced bi-directional modulation of intracellular kinases contributes to the inhibition of triple-negative breast cancer Open
View article: Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy Open
View article: Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy Open
Background Lipid metabolism is crucial in cancer progression. Lipid droplets (LDs) generated in cancer cells can act as protective mechanisms through alleviating lipotoxicity under stress conditions. We previously developed IC2 from the Ch…
View article: Systematic analysis of fatty acid desaturases in breast invasive carcinoma: The prognosis, gene mutation, and tumor immune microenvironment
Systematic analysis of fatty acid desaturases in breast invasive carcinoma: The prognosis, gene mutation, and tumor immune microenvironment Open
Breast invasive carcinoma (BRCA) is one of the most common cancers in women, with its malignant progression significantly influenced by intracellular fatty acid (FA) desaturation. Stearoyl-coenzyme A desaturase (SCD) and fatty acid desatur…
View article: Enhancement of efferocytosis through biased <scp>FPR2</scp> signaling attenuates intestinal inflammation
Enhancement of efferocytosis through biased <span>FPR2</span> signaling attenuates intestinal inflammation Open
Efficient clearance of dying cells (efferocytosis) is an evolutionarily conserved process for tissue homeostasis. Genetic enhancement of efferocytosis exhibits therapeutic potential for inflammation resolution and tissue repair. However, p…
View article: Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns Open
The formyl peptide receptor 1 (FPR1) is primarily responsible for detection of short peptides bearing N-formylated methionine (fMet) that are characteristic of protein synthesis in bacteria and mitochondria. As a result, FPR1 is critical t…
View article: Anti-inflammatory signaling through G protein-coupled receptors
Anti-inflammatory signaling through G protein-coupled receptors Open
View article: Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein
Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein Open
View article: A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2
A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2 Open
Formyl peptide receptors (FPRs) are G protein-coupled receptors (GPCRs) widely expressed in neutrophils and other phagocytes. FPRs play important roles in host defense, inflammation, and the pathogenesis of infectious and inflammatory dise…
View article: Structural basis of ligand binding modes at the human formyl peptide receptor 2
Structural basis of ligand binding modes at the human formyl peptide receptor 2 Open
The human formyl peptide receptor 2 (FPR2) plays a crucial role in host defense and inflammation, and has been considered as a drug target for chronic inflammatory diseases. A variety of peptides with different structures and origins have …
View article: 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists
4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-formyl peptide receptor 1 (FPR1) antagonists Open