Yunlong Fu
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View article: Preclinical Immunogenicity Evaluation of a DTacP-sIPV/Hib Combination Vaccine in Rodent Models Under Varying Formulations and Immunization Schedules
Preclinical Immunogenicity Evaluation of a DTacP-sIPV/Hib Combination Vaccine in Rodent Models Under Varying Formulations and Immunization Schedules Open
Background: Combination vaccines protecting against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b reduce injection burden and improve compliance. While widely used globally, no domestically produced penta…
View article: METTL3-mediated m6A modification of circCDKAL1 regulates macrophage M1 polarization and nasal epithelial cell barrier function in allergic rhinitis through IGF2BP2/JARID2/HMGB1 axis
METTL3-mediated m6A modification of circCDKAL1 regulates macrophage M1 polarization and nasal epithelial cell barrier function in allergic rhinitis through IGF2BP2/JARID2/HMGB1 axis Open
View article: Microstructure and mechanical properties of Al2O3 dispersion strengthened Cu by laser in-situ aluminum thermal reduction processing
Microstructure and mechanical properties of Al2O3 dispersion strengthened Cu by laser in-situ aluminum thermal reduction processing Open
View article: Identification of Milankovitch Cycles and Their Sedimentary Responses in Fine-Grained Depositional Strata on the Southwestern Margin of the Songliao Basin
Identification of Milankovitch Cycles and Their Sedimentary Responses in Fine-Grained Depositional Strata on the Southwestern Margin of the Songliao Basin Open
A series of fault depressions developed in the Kailu area on the southwestern margin of the Songliao Basin, where thick lacustrine fine-grained sedimentary rocks were widely deposited during the initial faulting stage in the Early Cretaceo…
View article: Poliovirus shedding after sequential immunization of Sabin-strain inactivated polio vaccines and oral attenuated polio vaccines
Poliovirus shedding after sequential immunization of Sabin-strain inactivated polio vaccines and oral attenuated polio vaccines Open
View article: A Convolutional Operator Search Method Based on XGBoost with Nearest Neighbor Search Convolutional operator search Convolutional operator search in math libraries
A Convolutional Operator Search Method Based on XGBoost with Nearest Neighbor Search Convolutional operator search Convolutional operator search in math libraries Open
View article: Effective laser cleaning of radar absorbing coatings on roughened aluminum alloys: surface integrity and overall performance
Effective laser cleaning of radar absorbing coatings on roughened aluminum alloys: surface integrity and overall performance Open
View article: The Effects of Mo and Zr Alloying On Microstructure and Hardness of Nb-Si Based Ultrahigh Temperature Alloys
The Effects of Mo and Zr Alloying On Microstructure and Hardness of Nb-Si Based Ultrahigh Temperature Alloys Open
View article: Fundamental investigation into mass transfer process and microstructural transformation pathways in Ti-6Al-4V via underwater wire-laser directed energy deposition
Fundamental investigation into mass transfer process and microstructural transformation pathways in Ti-6Al-4V via underwater wire-laser directed energy deposition Open
The in-situ analysis of mass transfer behaviours in a novel underwater wire-laser directed energy deposition (ULDED) technique was conducted using in-situ X-ray high-speed imaging. By creating a stable local dry cavity within the water env…
View article: Microstructure modulation and property enhancement via an underwater induction heating treatment strategy for underwater laser-directed energy deposition of Ti-6Al-4V
Microstructure modulation and property enhancement via an underwater induction heating treatment strategy for underwater laser-directed energy deposition of Ti-6Al-4V Open
In this study, an underwater in-situ induction heating treatment (UIHT)was carried out to modulate microstructure and improve the performance of underwater laser-directed energy deposition (ULDED) samples. The results showed that the redis…
View article: Underwater additive manufacturing of 10CrNi3MoV high-strength low-alloy steel by wire-feed laser melting deposition: Effect of microstructure evolution on mechanical properties
Underwater additive manufacturing of 10CrNi3MoV high-strength low-alloy steel by wire-feed laser melting deposition: Effect of microstructure evolution on mechanical properties Open
The underwater 10CrNi3MoV high-strength low-alloy steel thin-walled part with forming quality up to in-air laser deposition quality was successfully manufactured for the first time. The influencing mechanisms of complicated thermal history…
View article: Epigenetic-related gene-based prognostic model construction and validation in prostate adenocarcinoma
Epigenetic-related gene-based prognostic model construction and validation in prostate adenocarcinoma Open
Prostate adenocarcinoma (PRAD), driven by both genetic and epigenetic factors, is a common malignancy that affects men worldwide. We aimed to identify and characterize differentially expressed epigenetic-related genes (ERGs) in PRAD and in…
View article: Formation characterization and dynamic mechanism of underwater wet wire and arc directed energy deposition
Formation characterization and dynamic mechanism of underwater wet wire and arc directed energy deposition Open
For the first time, the underwater wet wire and arc directed energy deposition (UW-WADED) multi-tracks deposition layers with favorable morphology were obtained. The forming characteristics of single-track UW-WADED were determined through …
View article: Optimizing Formability Through Mass Transfer Control and Deciphering Microstructural Transformation Pathways in Ti-6al-4v Via Underwater Wire-Laser Directed Energy Deposition
Optimizing Formability Through Mass Transfer Control and Deciphering Microstructural Transformation Pathways in Ti-6al-4v Via Underwater Wire-Laser Directed Energy Deposition Open
View article: Targeting PD‐L1 with DNA Aptamers and Conjugated with Gemcitabine as a Novel Therapeutic Strategy for Bladder Cancer Chemotherapy Combined with Immunotherapy
Targeting PD‐L1 with DNA Aptamers and Conjugated with Gemcitabine as a Novel Therapeutic Strategy for Bladder Cancer Chemotherapy Combined with Immunotherapy Open
Cancer Therapy Aptamers have great functions in carrier drug delivery and have broad application prospects in the field of biomedicine. In article number 2300104, Jianye Liu and co-workers report the synthesis of a novel material, PD-L1-GE…
View article: Targeting PD‐L1 with DNA Aptamers and Conjugated with Gemcitabine as a Novel Therapeutic Strategy for Bladder Cancer Chemotherapy Combined with Immunotherapy
Targeting PD‐L1 with DNA Aptamers and Conjugated with Gemcitabine as a Novel Therapeutic Strategy for Bladder Cancer Chemotherapy Combined with Immunotherapy Open
Due to the poor stability and adverse effects of chemotherapy drugs, such as gemcitabine, the current effectiveness of traditional chemotherapy is minimal. Some patients also show a low response rate to immunotherapy. Therefore, a novel ma…
View article: Numerical simulation and experimental study on hot rolling forming of spur face gears
Numerical simulation and experimental study on hot rolling forming of spur face gears Open
Face gear transmission is the transmission mechanism composed of cylindrical gear and face gear. At present, the tooth making method of face gear is still tooth cutting, with low material utilization and low production efficiency. The meta…
View article: Microstructure and properties of in-situ nickel-aluminum bronze coating by underwater wire-feed laser cladding
Microstructure and properties of in-situ nickel-aluminum bronze coating by underwater wire-feed laser cladding Open
The in-situ laser cladding layer on nickel-aluminum bronze was prepared in water environment directly by the underwater wire-feed laser cladding technology for the first time, in which the local dry cavity was generated by a self-designed …
View article: DNA aptamers target PD-L1 and conjugate gemcitabine as a novel therapeutic strategy α β γ chemotherapy combined with immunotherapy for bladder cancer....
DNA aptamers target PD-L1 and conjugate gemcitabine as a novel therapeutic strategy α β γ chemotherapy combined with immunotherapy for bladder cancer.... Open
Due to the poor stability and adverse effects of chemotherapy drugs, such as gemcitabine, the current effectiveness of traditional chemotherapy is minimal. Some patients also show a low response rate to immunotherapy. Therefore, we have de…
View article: A novel approach of ultra-low diffusible hydrogen welding wire for underwater wet flux-cored arc welding: a spontaneous barrier of molten slag
A novel approach of ultra-low diffusible hydrogen welding wire for underwater wet flux-cored arc welding: a spontaneous barrier of molten slag Open
In underwater wet welding, a hydrogen-rich arc atmosphere generated by the thermal decomposition of water leads to extremely high diffusible hydrogen content and defects such as pores and cracks in the weld. In the present study, a neutral…
View article: Additive manufacturing of Ti-6Al-4V alloy by micro-laser metal wire deposition with pulsed wave emission: processability and microstructure formation
Additive manufacturing of Ti-6Al-4V alloy by micro-laser metal wire deposition with pulsed wave emission: processability and microstructure formation Open
View article: A novel strategy to prevent hydrogen charging via spontaneously molten-slag-covering droplet transfer mode in underwater wet FCAW
A novel strategy to prevent hydrogen charging via spontaneously molten-slag-covering droplet transfer mode in underwater wet FCAW Open
Underwater wet welding is widely used in offshore platform maintenance, oil pipeline repair and wreck salvage operations. A high diffusible hydrogen content is recognized as one of the critical reasons behind the reduction in the reliabili…
View article: Formation Characterization and Dynamic Mechanism of Underwater Wet Wire and Arc Directed Energy Deposition
Formation Characterization and Dynamic Mechanism of Underwater Wet Wire and Arc Directed Energy Deposition Open
View article: Investigation on in-situ laser cladding 5356 aluminum alloy coating on 5052 aluminum alloy substrate in water environment
Investigation on in-situ laser cladding 5356 aluminum alloy coating on 5052 aluminum alloy substrate in water environment Open
In this paper, underwater dissimilar aluminum alloy laser cladding has been investigated for the first time through a laser nozzle. The influences of water environment on laser cladding of dissimilar aluminum alloy were researched under op…
View article: In Situ Formation of Laser-Cladded Layer on Thin-Walled Tube of Aluminum Alloy in Underwater Environment
In Situ Formation of Laser-Cladded Layer on Thin-Walled Tube of Aluminum Alloy in Underwater Environment Open
The first study of thin-walled aluminum-alloy tubes with underwater-laser-nozzle in situ melting technology was carried out. The study mainly covered the influence of the water environment on the laser melting process, melting appearance, …
View article: Underwater Additive Manufacturing of Ti-6Al-4V Alloy by Laser Metal Deposition: Formability, Gran Growth and Microstructure Evolution
Underwater Additive Manufacturing of Ti-6Al-4V Alloy by Laser Metal Deposition: Formability, Gran Growth and Microstructure Evolution Open
No underwater laser additive manufacturing technology has been reported. In this paper, the underwater thin walled Ti-6Al-4V part was built firstly by underwater laser metal deposition (ULMD), and the formability, grain growth and microstr…
View article: Underwater laser welding for 304 stainless steel with filler wire
Underwater laser welding for 304 stainless steel with filler wire Open
Underwater laser welding for 304 stainless steel with filler wire was successfully performed with a self-designed double-side gas-shielding nozzle. The effects of the back gas flow rate, travel speed and wire feed speed on the welding appe…
View article: Underwater additive manufacturing of Ti-6Al-4V alloy by laser metal deposition: Formability, gran growth and microstructure evolution
Underwater additive manufacturing of Ti-6Al-4V alloy by laser metal deposition: Formability, gran growth and microstructure evolution Open
No underwater laser additive manufacturing technology has been reported. In this paper, the underwater thin-walled Ti-6Al-4V part was built firstly by underwater laser metal deposition (ULMD), and the formability, grain growth and microstr…
View article: Research on Underwater Laser Welding with Filler Wire Process of TC4 Titanium Alloy
Research on Underwater Laser Welding with Filler Wire Process of TC4 Titanium Alloy Open
TC4 钛合金水下激光填丝焊接工艺研究
View article: Underwater wire-feed laser deposition of the Ti–6Al–4V titanium alloy
Underwater wire-feed laser deposition of the Ti–6Al–4V titanium alloy Open
Underwater wire-feed laser deposition (UWLD) of the Ti–6Al–4V alloy was firstly carried out utilizing a laser deposition nozzle, and the deposition appearance, geometry characteristics, microstructure and microhardness of deposited tracks …