Yunlong Liu
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View article: Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder
Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder Open
View article: Genome-wide meta-analyses of cross substance use disorders in diverse populations
Genome-wide meta-analyses of cross substance use disorders in diverse populations Open
Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studie…
View article: Response to Comment on ‘A Mendelian Randomization Study About Causal Associations Between Tofu Consumption and Stroke As Well As Related Subtypes’
Response to Comment on ‘A Mendelian Randomization Study About Causal Associations Between Tofu Consumption and Stroke As Well As Related Subtypes’ Open
View article: Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of <i>Scn2a</i> -deficient mice
Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of <i>Scn2a</i> -deficient mice Open
Truncating variants in SCN2A , which encodes the NaV1.2 sodium channel critical for action potential initiation and propagation, are associated with autism spectrum disorder (ASD) and epilepsy. To investigate SCN2A deficiency–related pheno…
View article: ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche
ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche Open
Acute myeloid leukemia (AML) patients present with CD8 exhaustion signatures, and pharmacologic inhibition of checkpoints can have therapeutic benefit. The alarmin IL-33 and its receptor STimulation-2 (ST2) promote activation of tissue-reg…
View article: Single Cell Transcriptomic Analysis of Spinal Ependymoma from a Patient with NF2-related Schwannomatosis Indicates a Radial-Glia to Ependymal Cell Developmental Hierarchy
Single Cell Transcriptomic Analysis of Spinal Ependymoma from a Patient with NF2-related Schwannomatosis Indicates a Radial-Glia to Ependymal Cell Developmental Hierarchy Open
View article: i-Motif DNA molecular beacon for microRNA detection
i-Motif DNA molecular beacon for microRNA detection Open
A molecular beacon (MB) is an oligonucleotide probe with a stem-loop structure designed to fluoresce upon hybridization with a specific target nucleic acid. Herein, we introduce a novel i-motif DNA-based molecular beacon (iMB) designed for…
View article: Correction 2 for: Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury
Correction 2 for: Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury Open
View article: Author Correction: Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry
Author Correction: Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry Open
View article: Genomic and epigenomic insights into purkinje and granule neurons in Alzheimer’s disease and related dementia using single-nucleus multiome analysis
Genomic and epigenomic insights into purkinje and granule neurons in Alzheimer’s disease and related dementia using single-nucleus multiome analysis Open
Although the human cerebellum is known to be neuropathologically impaired in Alzheimer’s disease (AD) and AD-related dementias (ADRD), the cell type-specific transcriptional and epigenomic changes that contribute to this pathology are not …
View article: Protocol for labeling and manipulating “home”-activated neurons in mice
Protocol for labeling and manipulating “home”-activated neurons in mice Open
View article: Agricultural insurance improved soil nitrogen balance in China’s cities
Agricultural insurance improved soil nitrogen balance in China’s cities Open
Summary: Nitrogen (N) balance is crucial for effective agricultural N management and plays a significant role in safeguarding environmental security and human health. Agricultural insurance (AI) has been identified as an important financia…
View article: Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical Implications
Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical Implications Open
Multiple myeloma (MM) is a complex and heterogeneous hematologic malignancy characterized by clonal evolution, genetic instability, and interactions with a supportive tumor microenvironment. These factors contribute to treatment resistance…
View article: Systematic functional characterization of non-coding regulatory SNPs associated with central obesity
Systematic functional characterization of non-coding regulatory SNPs associated with central obesity Open
View article: Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis
Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis Open
Here, we used single cell RNA sequencing and single cell spatial transcriptomics to characterize the forebrain neural stem cell (NSC) niche under homeostatic and injury conditions. We defined the dorsal and lateral ventricular-subventricul…
View article: Alcohol Use Disorder Polygenic Score Compared With Family History and <i>ADH1B</i>
Alcohol Use Disorder Polygenic Score Compared With Family History and <i>ADH1B</i> Open
Importance Identification of individuals at high risk of alcohol use disorder (AUD) and subsequent application of prevention and intervention programs has been reported to decrease the incidence of AUD. The polygenic score (PGS), which mea…
View article: Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
View article: Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model
Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model Open
Polygenic risk scores (PRSs) assess genetic susceptibility to alcohol use disorder (AUD), yet their molecular implications remain underexplored. Neuroimmune interactions, particularly in microglia, are recognized as notable contributors to…
View article: Supplementary Table 1 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Supplementary Table 1 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open
Sequences
View article: Figure S4 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Figure S4 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open
Supplementary Figure 4
View article: Figure S2 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Figure S2 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open
Supplementary Figure 2
View article: Data from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Data from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open
The persistence of cancer stem cells (CSC) is believed to contribute to resistance to platinum-based chemotherapy and disease relapse in ovarian cancer, the fifth leading cause of cancer-related death among US women. HOXC transcript antise…
View article: Figure S1 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Figure S1 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open
Supplementary Figure 1
View article: Supplementary Table 2 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Supplementary Table 2 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open
Pathways
View article: Figure S3 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Figure S3 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open
Supplementary Figure 3
View article: Figure S5 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Figure S5 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2 Open
Supplementary Figure 5
View article: A Mendelian Randomization Study about Causal Associations between Tofu Consumption and Stroke as well as Related Subtypes
A Mendelian Randomization Study about Causal Associations between Tofu Consumption and Stroke as well as Related Subtypes Open
Objective: Consuming soy in the diet is beneficial for health, and tofu possess the richest source of dietary soy. However, the specific association with stroke and related subtypes remains controversial. In this study, the genetic causal …
View article: Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice
Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice Open
Home information profoundly influences behavioral states in both humans and animals. However, how "home" is represented in the brain and its role in driving diverse related behaviors remain elusive. Here, we demonstrate that home bedding c…
View article: Dynamic chromatin accessibility and transcriptome changes following PDGF-BB treatment of bone-marrow derived mesenchymal stem cells
Dynamic chromatin accessibility and transcriptome changes following PDGF-BB treatment of bone-marrow derived mesenchymal stem cells Open
In conclusion, the observed changes in AP-1 transcription factor expression not only induced cellular proliferation and differentiation, but also revealed variations in the degree of MSC differentiation based on donor-specific differences.…
View article: MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variants
MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variants Open
Summary Massively parallel reporter assay (MPRA) is an important technology for evaluating the impact of genetic variants on gene regulation. Here, we present MPRAVarDB, an online database and web server for exploring regulatory effects of…