Explanipedia

Tumor peripheral stiffness modulates lenvatinib resistance in HCC preclinical models by regulating FIS1-dependent mitophagy Open

Kunjin Wu, Huijuan Li, Yunong Fu, Kaibo Yang, Ting Lin , et al. · 2025

Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma Open

Kaibo Yang, Xing Zhang, Kun Yang, Sinan Liu, Jingyao Zhang , et al. · 2025

Resistance to tyrosine kinase inhibitors (TKIs) poses a significant challenge in the treatment of hepatocellular carcinoma (HCC). Although dysregulation of mitochondrial dynamics has been implicated in the aggressive behaviors of various t…

NEDD4 lactylation promotes APAP induced liver injury through Caspase11 dependent non-canonical pyroptosis Open

Qinglin Li, Fengping Zhang, Hai Wang, Yingmu Tong, Yunong Fu , et al. · 2024

Caspase-11 detection of intracellular lipopolysaccharide mediates non-canonical pyroptosis, which could result in inflammatory damage and organ lesions in various diseases such as sepsis. Our research found that lactate from the microenvir…

Identification of hepatocellular carcinoma subtypes based on PcG-related genes and biological relevance with cancer cells Open

Yunong Fu, Kaibo Yang, Kunjin Wu, Hai Wang, Qinglin Li , et al. · 2022

Background Hepatocellular carcinoma (HCC) is an extensive heterogeneous disease where epigenetic factors contribute to its pathogenesis. Polycomb group (PcG) proteins are a group of subunits constituting various macro-molecular machines to…

Identification of an epigenetic classification for hepatocellular carcinoma and biological relevance with cancer cells Open

Yunong Fu, Kaibo Yang, Kunjin Wu, Hai Wang, Qinglin Li , et al. · 2022

Background: Hepatocellular carcinoma (HCC) is an extensive heterogeneous disease where epigenetic factors contribute to its pathogenesis. Polycomb group (PcG) proteins are a group of subunits constituting various macro molecular machines t…

Development of an Early Warning Model for Predicting the Death Risk of Coronavirus Disease 2019 Based on Data Immediately Available on Admission Open

Hai Wang, Haibo Ai, Yunong Fu, Qinglin Li, Ruixia Cui , et al. · 2021

Introduction: COVID-19 has overloaded worldwide medical facilities, leaving some potentially high-risk patients trapped in outpatient clinics without sufficient treatment. However, there is still a lack of a simple and effective tool to id…

HN1 Promotes Proliferation, Metastasis and Attenuates the Chemosensitivity of HCC Cells to Oxaliplatin by Inhibiting Degradation of HMGB1 Through Interacting With TRIM28 Open

Ruhua Wang, Yunong Fu, Menglin Yao, Xiaomeng Cui, Yan Zhao , et al. · 2021

Background: The oxaliplatin-based chemotherapy has revealed an encouraging therapeutic efficacy for advanced hepatocellular carcinoma patients. However, the development of resistance limits its clinical utilization. In addition, the chemot…

CDC20, A Hypermethylated Gene in Senescent Cells, is Associated with Hepatocellular Carcinoma Prognosis Open

Xiang Xian-hong, Yunong Fu, Xing Zhang, Runchen Miao, Xiaohua Ma , et al. · 2021

BackgroundHepatocellular carcinoma (HCC) is a malignancy with poor outcome. As an anti-tumor mechanism, the methylation pattern of gene in senescent cells is different from that in malignant ones deriving from physically senescent cells. T…

Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated <i>PHB2</i> Open

Xiaohong Xiang, Yunong Fu, Kun Zhao, Runchen Miao, Xing Zhang , et al. · 2021

Rationale: Recently, long non-coding RNAs (lncRNAs), known to be involved in human cancer progression, have been shown to encode peptides with biological functions, but the role of lncRNA-encoded peptides in cellular senescence is l…

Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma Open

Xiaohong Xiang, Li Yang, Xing Zhang, Xiaohua Ma, Runchen Miao , et al. · 2019

We developed a seven-SAG signature, which could predict OS of Asian HCC patients. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC.

IDH1 as a frequently mutated gene has potential effect on exosomes releasement by epigenetically regulating P2RX7 in intrahepatic cholangiocarcinoma Open

Xing Zhang, Runchen Miao, Tian Liu, Xiaohong Xiang, Jingxian Gu , et al. · 2019

Biliary tract cancers (BTCs) was heterogeneous and characterized by late diagnosis and fatal outcome. To identify new biomarkers for BTCs, we performed Robust Rank Aggreg (RRA) analysis and identified that IDH1 mutation was common in ICC, …

Three hypomethylated genes were associated with poor overall survival in pancreatic cancer patients Open

Hui-Ming Chen, Yan Kong, Qing Yao, Xing Zhang, Yunong Fu , et al. · 2019

Pancreatic cancer (PC) is a highly malignant cancer with poor prognosis and high mortality. Aberrant DNA methylation plays a critical role in the occurrence, progression and prognosis of malignant tumors. In this study, we employed multipl…

Combined eight-long noncoding RNA signature: a new risk score predicting prognosis in elderly non-small cell lung cancer patients Open

Runchen Miao, Cuiyun Ge, Xing Zhang, Yang He, Xiaohua Ma , et al. · 2019

The elderly are the majority of patients with non-small cell lung cancer (NSCLC). Compared to the overall population's predictive guidance, an effective predictive guidance for elderly patients can better guide patients' postoperative trea…

Hypomethylated gene NRP1 is co-expressed with PDGFRB and associated with poor overall survival in gastric cancer patients Open

Guanghui Wang, Bin Shi, Yunong Fu, Shasha Zhao, Kai Qu , et al. · 2019

Gastric cancer (GC) has been an increasingly serious problem in public health. However, there is still a lack of efficient approach to diagnosis and treatment in time, especially in the field of targeted therapy. Increasing evidences demon…

Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma Open

Jingxian Gu, Xing Zhang, Runchen Miao, Xiaohong Xiang, Yunong Fu , et al. · 2019

We have constructed a six-lncRNA signature for prognosis prediction of HCC. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC.

A new risk score based on twelve hepatocellular carcinoma-specific gene expression can predict the patients’ prognosis Open

Ting Lin, Jingxian Gu, Kai Qu, Xing Zhang, Xiaohua Ma , et al. · 2018

A large panel of molecular biomarkers have been identified to predict the prognosis of hepatocellular carcinoma (HCC), yet with limited clinical application due to difficult extrapolation. We here generated a genetic risk score system comp…

A seven-long noncoding RNA signature predicts overall survival for patients with early stage non-small cell lung cancer Open

Ting Lin, Yunong Fu, Xing Zhang, Jingxian Gu, Xiaohua Ma , et al. · 2018

Non-small cell lung cancer (NSCLC) is the most common cancer and cause of cancer-related mortality globally. Increasing evidence suggested that the long non-coding RNAs (lncRNAs) were involved in cancer-related death. To explore the possib…

A three-long non-coding RNA-expression-based risk score system can better predict both overall and recurrence-free survival in patients with small hepatocellular carcinoma Open

Jingxian Gu, Xing Zhang, Runchen Miao, Xiaohua Ma, Xiaohong Xiang , et al. · 2018

Growing evidence indicates that long non-coding RNAs (lncRNAs) may be potential biomarkers and therapeutic targets for many disease conditions, including cancer. In this study, we constructed a risk score system of three lncRNAs (LOC101…

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