Yunping Zhou
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View article: Global, regional, and national burden of falls in middle-aged and elderly individuals from 1990 to 2021: findings from the Global Burden of Disease study 2021
Global, regional, and national burden of falls in middle-aged and elderly individuals from 1990 to 2021: findings from the Global Burden of Disease study 2021 Open
View article: Intergenerational Transmission of Proactive Health Behaviors Among Adolescents with Overweight or Obesity: The Mediating Role of Self-Efficacy and Family Cohesion
Intergenerational Transmission of Proactive Health Behaviors Among Adolescents with Overweight or Obesity: The Mediating Role of Self-Efficacy and Family Cohesion Open
Background/Objectives: The family environment exerts a significant influence on the development of weight-related behaviors among adolescents. However, the lack of motivation often leads to failure in sustaining health behaviors, particula…
View article: The association of the triglyceride-glucose index and its changes with 5-year all-cause mortality in patients with depression
The association of the triglyceride-glucose index and its changes with 5-year all-cause mortality in patients with depression Open
Background Depression, as the primary contributor to the global disease burden caused by mental disorders, necessitates the urgent discovery of new biomarkers to predict patient prognosis, thereby facilitating early treatment. The triglyce…
View article: Effect of acetaminophen on the short-term mortality of hospitalized patients with hypertension: A retrospective cohort study
Effect of acetaminophen on the short-term mortality of hospitalized patients with hypertension: A retrospective cohort study Open
Hypertension represents a leading risk factor for morbidity and mortality worldwide. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, exhibits a mechanism distinct from nonsteroidal anti-inflammatory drugs. APAP is widel…
View article: Safety, Tolerability, and Pharmacokinetics of Once-Monthly Oral Islatravir: A Phase 2a Study in Participants at Low Risk for Acquiring Human Immunodeficiency Virus Type 1
Safety, Tolerability, and Pharmacokinetics of Once-Monthly Oral Islatravir: A Phase 2a Study in Participants at Low Risk for Acquiring Human Immunodeficiency Virus Type 1 Open
Background Islatravir, a nucleoside reverse transcriptase translocation inhibitor, exhibits high potency against human immunodeficiency virus type 1 (HIV-1), with a long intracellular half-life. The safety, tolerability, and pharmacokineti…
View article: Innovation in Medical Evidence and Development Surveillance (IMEDS): A Network of Real-World Data Sources for Pharmacoepidemiologic Studies
Innovation in Medical Evidence and Development Surveillance (IMEDS): A Network of Real-World Data Sources for Pharmacoepidemiologic Studies Open
View article: Discovering Topics and Trends in Artificial Intelligence Chatbots in Medicine: Using Latent Dirichlet Allocation Topic Modeling (Preprint)
Discovering Topics and Trends in Artificial Intelligence Chatbots in Medicine: Using Latent Dirichlet Allocation Topic Modeling (Preprint) Open
BACKGROUND With the widespread adoption of the internet and smart devices, chatbots have emerged as significant auxiliary tools for public health activities. Despite the increasing application of chatbots in the medical field, comprehensi…
View article: The transformative breakthroughs in GLP-1 research recognized by the 2024 Lasker~DeBakey award
The transformative breakthroughs in GLP-1 research recognized by the 2024 Lasker~DeBakey award Open
View article: Associations between social support and proactive health behaviours among Chinese adolescents: the mediating role of self-efficacy and peer relationships
Associations between social support and proactive health behaviours among Chinese adolescents: the mediating role of self-efficacy and peer relationships Open
View article: Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in the Elderly with Alzheimer’s Disease (D-PRESCRIBE-AD): Trial protocol and rationale of an open-label pragmatic, prospective randomized controlled trial
Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in the Elderly with Alzheimer’s Disease (D-PRESCRIBE-AD): Trial protocol and rationale of an open-label pragmatic, prospective randomized controlled trial Open
Context Potentially inappropriate prescribing of medications in older adults, particular those with dementia, can lead to adverse drug events including falls and fractures, worsening cognitive impairment, emergency department visits, and h…
View article: Risk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States
Risk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States Open
There was heterogeneity by country in 90-day absolute risk of ATE and VTE after ambulatory COVID-19 diagnosis both before and during COVID-19 vaccine availability.
View article: Efficacy of cognitive behavioral therapy for insomnia in the perinatal period: a meta-analysis of randomized controlled trials
Efficacy of cognitive behavioral therapy for insomnia in the perinatal period: a meta-analysis of randomized controlled trials Open
View article: Weight change across adulthood in relation to the risk of depression
Weight change across adulthood in relation to the risk of depression Open
Background Studies examining weight change patterns and depression are scarce and report inconsistent findings. This study—aimed to elucidate the association between weight change patterns and the risk of depression in a large, representat…
View article: Association between the TAPSE to PASP ratio and short-term outcome in patients with light-chain cardiac amyloidosis
Association between the TAPSE to PASP ratio and short-term outcome in patients with light-chain cardiac amyloidosis Open
The TAPSE/PASP ratio is associated with the short-term outcome of patients with AL-CA. The combination of TAPSE/PASP ratio < 0.474 mmHg and SBP < 100 mmHg could identify the subgroup of patients with AL-CA at elevated risk of poor prognosi…
View article: Risk of admission to hospital with arterial or venous thromboembolism among patients diagnosed in the ambulatory setting with covid-19 compared with influenza: retrospective cohort study
Risk of admission to hospital with arterial or venous thromboembolism among patients diagnosed in the ambulatory setting with covid-19 compared with influenza: retrospective cohort study Open
Objective To measure the 90 day risk of arterial thromboembolism and venous thromboembolism among patients diagnosed with covid-19 in the ambulatory (ie, outpatient, emergency department, or institutional) setting during periods before and…
View article: Phase Equilibrium of Ternary System of Cdcl2 + L-Proline (Trans-4-Oh-L-Proline) + H2o and the Standard Molar Enthalpy of Formation of Cd(C5h9no2)Cl2∙H2o and Cd(C5h9no3)Cl2
Phase Equilibrium of Ternary System of Cdcl2 + L-Proline (Trans-4-Oh-L-Proline) + H2o and the Standard Molar Enthalpy of Formation of Cd(C5h9no2)Cl2∙H2o and Cd(C5h9no3)Cl2 Open
View article: Association of COVID-19 vs Influenza With Risk of Arterial and Venous Thrombotic Events Among Hospitalized Patients
Association of COVID-19 vs Influenza With Risk of Arterial and Venous Thrombotic Events Among Hospitalized Patients Open
Importance The incidence of arterial thromboembolism and venous thromboembolism in persons with COVID-19 remains unclear. Objective To measure the 90-day risk of arterial thromboembolism and venous thromboembolism in patients hospitalized …
View article: Effect of Mailing Educational Material to Patients With Atrial Fibrillation and Their Clinicians on Use of Oral Anticoagulants
Effect of Mailing Educational Material to Patients With Atrial Fibrillation and Their Clinicians on Use of Oral Anticoagulants Open
ClinicalTrials.gov Identifier: NCT03259373.
View article: Distinct Patterns of Urban-Rural and Sex Disparities in Children's BMI Trajectories From 2013 to 2018
Distinct Patterns of Urban-Rural and Sex Disparities in Children's BMI Trajectories From 2013 to 2018 Open
Background: To identify distinct trajectories of body mass index (BMI) in a large sample of Chinese children by urban-rural and sex disparities. Methods: Data for this study were obtained from the National Surveys on Chinese Students' Cons…
View article: Weight gain from early to middle adulthood increases the risk of incident asthma later in life in the United States: a retrospective cohort study
Weight gain from early to middle adulthood increases the risk of incident asthma later in life in the United States: a retrospective cohort study Open
View article: Association of bisphenol A with puberty timing: a meta-analysis
Association of bisphenol A with puberty timing: a meta-analysis Open
Objectives The results of existing studies on bisphenol A (BPA) and puberty timing did not reach a consensus. Thereby we performed this meta-analytic study to explore the association between BPA exposure in urine and puberty timing. Method…
View article: Weight Change from Early to Middle Adulthood and Incident Asthma Later in Life: A Retrospective Cohort Study
Weight Change from Early to Middle Adulthood and Incident Asthma Later in Life: A Retrospective Cohort Study Open
Background: Data describing the effects of weight change across adulthood on asthma are important for the prevention of asthma. This study aimed to investigate the association between weight change from early to middle adulthood and risk o…
View article: Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life
Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life Open
Background: The effect of obesity in early adulthood and weight loss on incident hypertension in older age has not been well characterized. This study aimed to examine the association of weight loss from young adulthood to midlife with ris…
View article: Association of Cesarean Birth with Body Mass Index Trajectories in Adolescence
Association of Cesarean Birth with Body Mass Index Trajectories in Adolescence Open
Background: This study aimed to identify patterns of body mass index (BMI) changes in adolescence and to assess whether delivery mode (Cesarean and vaginal delivery) was associated with BMI trajectories. Methods: This study was conducted a…
View article: 702. Hepatic Safety Among Patients Treated with Anti-Fungal Triazole Agent Posaconazole: Characterization of Adverse events in a Manufacturer’s Safety Database
702. Hepatic Safety Among Patients Treated with Anti-Fungal Triazole Agent Posaconazole: Characterization of Adverse events in a Manufacturer’s Safety Database Open
Background Second-generation triazoles including posaconazole are highly efficacious for the prophylaxis and salvage treatment of life-threatening invasive fungal diseases. All triazoles have been associated with hepatic adverse events (AE…
View article: Evaluation of Neural Tube Defects (NTDs) After Exposure to Raltegravir During Pregnancy
Evaluation of Neural Tube Defects (NTDs) After Exposure to Raltegravir During Pregnancy Open
Objective: To evaluate the risk of neural tube defects (NTDs) after exposure to raltegravir during pregnancy. Methods: Exposures to raltegravir during pregnancy reported cumulatively through May 31, 2018, to the company safety database wer…
View article: The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones Open
View article: Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition
Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition Open
We report new SSTR5 antagonists with enhanced potency, subtype selectivity, and minimal off-target activities as compared to previously reported compounds. Starting from the reported SSTR5 antagonist 1, we systematically surveyed ch…
View article: SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists
SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists Open
View article: COPD exacerbation frequency and its association with health care resource utilization and costs
COPD exacerbation frequency and its association with health care resource utilization and costs Open
COPD patients frequently experience exacerbations. Increasing exacerbation frequency is associated with a multiplicative increase in all-cause and COPD-related costs. This underscores the importance of identifying COPD patients at risk of …