Explanipedia

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU Open

Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Zhonglin Wang, Xiaoyan Zeng , et al. · 2025

Finding novel compounds and drug targets is crucial for antibiotic development. The nucleoid‐associated protein HU plays a significant role in bacterial DNA metabolism, supercoiling, and biofilm formation, making it a promising new target.…

Mechanism And Application Status Of CAR-T Cell Immunotherapy Open

Yahui Liu · 2025

With the continuous increase in the incidence and mortality of cancer, finding more accurate and effective treatment methods has become an important direction of medical research. As an important technological breakthrough in the field of …

Progress in antileishmanial drugs: Mechanisms, challenges, and prospects Open

Haoran Zhang, Ruixi Yan, Yahui Liu, Mengtao Yu, Ziyi He , et al. · 2025

Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to pose global health challenges. Current treatments face issues like resistance, safety, efficacy, and cost. This review covers the discovery, mechanism…

Structural insight into EV-A71 3A protein and its interaction with a peptide inhibitor Open

Yahui Liu, Panjing Lv, Wei Wang, Jiahai Zhang, Zhou Xi , et al. · 2023

• Our results disclosed a dihelical structure of Enterovirus A71 3A(1–57) protein in apo form. • We depicted rigid helices and a unique flexible C-terminus for apo-form 3A(1–57). • This study revealed a competitive binding-based molecular …

Advances in developing ACE2 derivatives against SARS-CoV-2 Open

Haoran Zhang, Panjing Lv, Jingrui Jiang, Yahui Liu, Ruixi Yan , et al. · 2023

Biophysical and Biochemical Characterization of the Binding of the MarR-like Transcriptional Regulator Saro_0803 to the nov1 Promotor and Its Inhibition by Resveratrol Open

Zhen He, Zunhui Ke, Wei Wang, Yahui Liu, Haoran Zhang , et al. · 2023

Saro_0803 is a transcriptional factor modulating the transcription of the stilbene-degrading enzyme gene nov1 in Novosphingobium aromaticivorans DSM 12444. Reportedly, Saro_0803 undergoes resveratrol-mediated dissociation from the nov1 pro…

Cinnamobactins is a New Mechanistic Class of Antibiotics Discovered with the Inspirations from Bacteriophage and Artificial Intelligence Open

Huan Chen, Yingqi Xu, Zhaoping Xiong, Xin Wang, Yue Kang , et al. · 2023

An ACE2-Based Decoy Inhibitor Effectively Neutralizes SARS-CoV-2 Omicron BA.5 Variant Open

Haoran Zhang, Bing Hu, Panjing Lv, Yahui Liu, Meng Guo , et al. · 2022

The recently circulating SARS-CoV-2 Omicron BA.5 is rampaging the world with elevated transmissibility compared to the original SARS-CoV-2 strain. Immune escape of BA.5 was observed after treatment with many monoclonal antibodies, calling …

Structural Insights into Mouse H-FABP Open

Lili Wang, Haoran Zhang, Panjing Lv, Yan Li, Maikun Teng , et al. · 2022

Intracellular fatty acid-binding proteins are evolutionarily highly conserved proteins. The major functions and responsibilities of this family are the regulation of FA uptake and intracellular transport. The structure of the H-FABP orthol…

Pancreatic fistula and biliary fistula after laparoscopic pancreatoduodenectomy: 500 patients at a single institution Open

Ruobing Wang, Peiqiang Jiang, Qingmin Chen, Songyang Liu, Feng Jia , et al. · 2022

Background: Pancreatic fistula (PF) and biliary fistula (BF) are two major leakage complications after pancreatoduodenectomy (PD). The aim of this study is to investigate the risk factors of PF and BF after laparoscopic PD (LPD). Materials…

The Self-Activation Mechanism of Type Iie Restriction Endonuclease Sau3ai Open

Yahui Liu, Chunyan Xu, Huan Zhou, Weiwei Wang, Bing Liu , et al. · 2022

Erratum for Zhao et al., “Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1” Open

Kaitao Zhao, Zunhui Ke, Hongbing Hu, Yahui Liu, Aixin Li , et al. · 2021

Volume 9, issue 1, e00169-21, https://doi.org/10.1128/Spectrum.00169-21, 2021. In the originally published version, a supplemental material file was posted and a list of supplemental material appeared on p. 10. On 14 July 2021, the article…

Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1 Open

Kaitao Zhao, Zunhui Ke, Hongbing Hu, Yahui Liu, Aixin Li , et al. · 2021

Nonstructural protein 1 (Nsp1) of severe acute respiratory syndrome coronaviruses (SARS-CoVs) is an important pathogenic factor that inhibits host protein translation by means of its C terminus. However, its N-terminal function remains elu…

Ligands of the peroxisome proliferator-activated receptor γ inhibit hepatoce llular carcinoma cell proliferation Open

Zhe Jin, Baoxing Jia, Yu Fu, Ludong Tan, Qingmin Chen , et al. · 2017

This study was designed to investigate the regulatory role of the peroxisome proliferator-activated receptor γ (PPARγ) in the growth of hepatocellular carcinoma cells under the hypothesis that the levels of the phosphatase and tensin homol…

The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics Open

Yahui Liu, Tian Liu, Jinxiang Wu, Tao Li, Xingai Jiao , et al. · 2017

Background . Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. Objectives . To analyze the as…

Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores Open

Arsen Petrović, Jenny Keller, Yahui Liu, Katharina Overlack, Juliane John , et al. · 2016

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