Yunyun An
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View article: Sensitive monitoring of xenograft cancer models using cell-free DNA
Sensitive monitoring of xenograft cancer models using cell-free DNA Open
View article: Cancer-like fragmentomic characteristics of somatic variants in cell-free DNA
Cancer-like fragmentomic characteristics of somatic variants in cell-free DNA Open
Cell-free DNA (cfDNA) in plasma consists of short DNA fragments resulting from a non-random fragmentation process, with distinct “fragmentomic” characteristics that are related with their cellular origins. Despite the wealth of low-pass wh…
View article: Publisher Correction: Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer
Publisher Correction: Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer Open
View article: Protocol for the analysis of cell-free DNA end characteristics for accurate cancer diagnosis
Protocol for the analysis of cell-free DNA end characteristics for accurate cancer diagnosis Open
View article: Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer
Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer Open
Proteasome is an essential organelle responsible for maintaining cellular protein homeostasis, but its relationship with DNA methylation remains unknown. In this study, we assessed DNA methylation of colorectal cancer (CRC) cells following…
View article: The RNA fusion landscape of human placentae and pre-eclampsia
The RNA fusion landscape of human placentae and pre-eclampsia Open
View article: Expression pattern of glutaminase informs the dynamics of glutamine metabolism
Expression pattern of glutaminase informs the dynamics of glutamine metabolism Open
Glutamine is an essential nutrient that plays critical roles in both normal physiological processes and disease pathogenesis. In this study, we introduce a quantitative approach to trace the dynamics of glutamine metabolism by monitoring t…
View article: Cell-free DNA end characteristics enable accurate and sensitive cancer diagnosis
Cell-free DNA end characteristics enable accurate and sensitive cancer diagnosis Open
View article: Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer
Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer Open
Proteasome is an essential organelle in guarding cellular protein homeostasis. Here, we report that inhibition of proteasome leads to alterations in DNA methylation patterns in colorectal cancer (CRC) by surpressing the synthesis of DNA me…
View article: Systematic biases in reference-based plasma cell-free DNA fragmentomic profiling
Systematic biases in reference-based plasma cell-free DNA fragmentomic profiling Open
Plasma cell-free DNA (cfDNA) fragmentation patterns are emerging directions in cancer liquid biopsy with high translational significance. Conventionally, the cfDNA sequencing reads are aligned to a reference genome to extract their fragmen…
View article: Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology
Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology Open
In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (i.e., precision oncology) are widely implemented to provide clinical benefits for cancer patients. Here, through in-depth integration of tumor trans…
View article: DNA methylation analysis explores the molecular basis of plasma cell-free DNA fragmentation
DNA methylation analysis explores the molecular basis of plasma cell-free DNA fragmentation Open
Plasma cell-free DNA (cfDNA) are small molecules generated through a non-random fragmentation procedure. Despite commendable translational values in cancer liquid biopsy, however, the biology of cfDNA, especially the principles of cfDNA fr…
View article: Msuite2: All-in-one DNA methylation data analysis toolkit with enhanced usability and performance
Msuite2: All-in-one DNA methylation data analysis toolkit with enhanced usability and performance Open
View article: Recent Advances in Liquid Biopsy of Brain Cancers
Recent Advances in Liquid Biopsy of Brain Cancers Open
Brain cancers are among the top causes of death worldwide. Although, the survival rates vary widely depending on the type of the tumor, early diagnosis could generally benefit in better prognosis outcomes of the brain cancer patients. Conv…
View article: Dynamic epigenome changes in response to light in Brachypodium distachyon
Dynamic epigenome changes in response to light in Brachypodium distachyon Open
Light plays an important role in many plant biological processes such as photosynthesis and photomorphogenesis. In this study, we applied RNA-seq, ATAC-seq and ChIP-seq to study transcriptional regulation at multiple levels in Brachypodium…