Ying Hé
YOU?
Author Swipe
View article: The effect of bullying victimization trajectory on internet gaming disorder and the mediating role of impaired resilience: a three-wave cohort study among Chinese adolescents
The effect of bullying victimization trajectory on internet gaming disorder and the mediating role of impaired resilience: a three-wave cohort study among Chinese adolescents Open
View article: 289 Therapeutic Potential of MY004, an IRAK4 Inhibitor, in Psoriasis: Preclinical Activity and Molecular Mechanism
289 Therapeutic Potential of MY004, an IRAK4 Inhibitor, in Psoriasis: Preclinical Activity and Molecular Mechanism Open
View article: Investigating the mechanism of gastrodin-regulated miR-128-3p in methamphetamine dependence via integrated pharmacology
Investigating the mechanism of gastrodin-regulated miR-128-3p in methamphetamine dependence via integrated pharmacology Open
Gastrodin (GAS), the principal bioactive component derived from Gastrodia elata Bl., has demonstrated efficacy in attenuating methamphetamine (MA) induced conditioned place preference (CPP) in animal models. However, the molecular mechanis…
View article: Impact of postpartum persistent depression on infant developmental behavior and maternal self-efficacy
Impact of postpartum persistent depression on infant developmental behavior and maternal self-efficacy Open
BACKGROUND Postpartum depression (PPD) represents a significant public health concern, adversely affecting both new mothers and their infants. Despite routine early screening, PPD can persist beyond the initial postpartum months, with nota…
View article: A frame network study of first-episode schizophrenia, ultra-high risk, and healthy populations
A frame network study of first-episode schizophrenia, ultra-high risk, and healthy populations Open
Schizophrenia is a complex neuropsychiatric disorder, and the abnormalities in brain networks during its early stages remain incompletely understood. Previously, we identified a stable high-intensity functional network, termed the "Frame N…
View article: Trajectory of internet gaming disorder among Chinese adolescents: Course, predictors, and long-term mental health outcomes
Trajectory of internet gaming disorder among Chinese adolescents: Course, predictors, and long-term mental health outcomes Open
Background and Objectives Internet gaming disorder (IGD) is a growing public health concern, especially among adolescents. However, most IGD studies are cross-sectional, leaving its developmental course poorly understood. This study examin…
View article: Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats
Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats Open
Background Methamphetamine (MA) is one of the most harmful synthetic drugs, yet the mechanisms underlying its addiction and relapse remain incompletely understood. This study investigates how cardiomyocyte-derived exosomes carrying miRNAs …
View article: The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder
The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder Open
The 4977 bp deletion may be a trait marker for MDD.
View article: Impaired sleep quality mediates the relationship between internet gaming disorder and conduct problems among adolescents: a three-wave longitudinal study
Impaired sleep quality mediates the relationship between internet gaming disorder and conduct problems among adolescents: a three-wave longitudinal study Open
Background Research increasingly demonstrates a positive association between Internet Gaming Disorder (IGD) and conduct problems among adolescents. However, longitudinal data are limited, and the mediating mechanisms remain unclear. This s…
View article: Positive correlation between post-cessation weight concerns and intentions to quit smoking in Chinese male smokers: A cross-sectional study
Positive correlation between post-cessation weight concerns and intentions to quit smoking in Chinese male smokers: A cross-sectional study Open
The extent of post-cessation weight concerns was low, partially due to the low perception of weight gain associated with smoking cessation. Moreover, the intentions to quit smoking were positively associated with post-cessation weight conc…
View article: Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia
Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia Open
The striatum, a core brain structure relevant for schizophrenia, exhibits heterogeneous volumetric changes in this illness. Due to this heterogeneity, its role in the risk of developing schizophrenia following exposure to environmental str…
View article: Internet gaming disorder and depression mediated by impaired resilience and sleep distress: a three-wave longitudinal study among Chinese adolescents
Internet gaming disorder and depression mediated by impaired resilience and sleep distress: a three-wave longitudinal study among Chinese adolescents Open
Aims While the cross-sectional relationship between internet gaming disorder (IGD) and depression is well-established, whether IGD predicts future depression remains debated, and the underlying mechanisms are not fully understood. This lar…
View article: The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders: A Two-Step Mendelian Randomization Analysis
The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders: A Two-Step Mendelian Randomization Analysis Open
Background and Hypothesis Inflammatory proteins are implicated in psychiatric disorders, but the causality and underlying mechanisms remain unclear. Study Design We conducted bidirectional Mendelian randomization (MR) using genetic variant…
View article: Glutamate levels and symptom burden in high-risk and first-episode schizophrenia: a dual-voxel study of the anterior cingulate cortex
Glutamate levels and symptom burden in high-risk and first-episode schizophrenia: a dual-voxel study of the anterior cingulate cortex Open
Background Reduced glutamatergic excitability of the anterior cingulate cortex (ACC) has been long suspected in schizophrenia; recent observations support low glutamatergic tone as the primary pathophysiology contributing to subtle early f…
View article: Brain Age Gap as a Predictor of Early Treatment Response and Functional Outcomes in First-Episode Schizophrenia: A Longitudinal Study: L'écart d'âge cérébral comme prédicteur de la réponse en début de traitement et des résultats fonctionnels dans un premier épisode de schizophrénie : une étude longitudinale
Brain Age Gap as a Predictor of Early Treatment Response and Functional Outcomes in First-Episode Schizophrenia: A Longitudinal Study: L'écart d'âge cérébral comme prédicteur de la réponse en début de traitement et des résultats fonctionnels dans un premier épisode de schizophrénie : une étude longitudinale Open
Objectives Accelerated brain aging, i.e., the age-related structural changes in the brain appearing earlier than expected from one's chronological age, is a feature that is now well established in schizophrenia. Often interpreted as a feat…
View article: Correlation Between Cortical Thickness Abnormalities of the Olfactory Sulcus and Olfactory Identification Disorder and Persistent Auditory Verbal Hallucinations in Chinese Patients With Chronic Schizophrenia
Correlation Between Cortical Thickness Abnormalities of the Olfactory Sulcus and Olfactory Identification Disorder and Persistent Auditory Verbal Hallucinations in Chinese Patients With Chronic Schizophrenia Open
Background and Hypothesis Persistent auditory verbal hallucinations (pAVHs) and olfactory identification impairment are common in schizophrenia (SCZ), but the neuroimaging mechanisms underlying both pAVHs and olfactory identification impai…
View article: Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk
Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk Open
Machine learning approaches using structural magnetic resonance imaging (sMRI) can be informative for disease classification, although their ability to predict psychosis is largely unknown. We created a model with individuals at CHR who de…
View article: A multistage, dual voxel study of glutamate in the anterior cingulate cortex in schizophrenia supports a primary pyramidal dysfunction model of disorganization
A multistage, dual voxel study of glutamate in the anterior cingulate cortex in schizophrenia supports a primary pyramidal dysfunction model of disorganization Open
Background Schizophrenia is an illness where glutamatergic dysfunction in the anterior cingulate cortex (ACC) has been long suspected; Recent in vivo evidence (Adams et al. 2022) has implicated pyramidal dysfunction (reduced glutamate tone…
View article: The Relationship Between Level of Education, Cognitive Function and Medication Adherence in Patients with Schizophrenia
The Relationship Between Level of Education, Cognitive Function and Medication Adherence in Patients with Schizophrenia Open
Adopting specific education programs that promote cognitive development as well as actively intervening in executive function might be conducive to improve medication adherence in patients with schizophrenia.
View article: Association between childhood trauma and Internet gaming disorder: a moderated mediation analysis of depression as a mediator and psychological resilience as a moderator
Association between childhood trauma and Internet gaming disorder: a moderated mediation analysis of depression as a mediator and psychological resilience as a moderator Open
Background Internet gaming disorder (IGD) is a severe mental health disorder. The effect of childhood trauma on IGD is currently unclear. Therefore, this study examined the association between childhood trauma and IGD among Chinese student…
View article: Prevalence and associated factors of depressive and anxiety symptoms among Chinese secondary school students
Prevalence and associated factors of depressive and anxiety symptoms among Chinese secondary school students Open
View article: Glutamatergic basis of antipsychotic response in first-episode psychosis: a dual voxel study of the anterior cingulate cortex
Glutamatergic basis of antipsychotic response in first-episode psychosis: a dual voxel study of the anterior cingulate cortex Open
Treatment-resistant schizophrenia is believed to be related to excess prefrontal glutamate. If we can identify these individuals early in the course of illness, the repeated use of first-line antipsychotics can be reduced and first-episode…
View article: The month of walking alone and BDNF level differ between drug-naive first-episode schizophrenia patients and healthy controls
The month of walking alone and BDNF level differ between drug-naive first-episode schizophrenia patients and healthy controls Open
Introduction Schizophrenia is a neurodevelopmental disorder, characterized by impairment in reasoning, affectivity, and social relationships. Previous studies have shown delayed motor development and Brain-Derived Neurotrophic Factor (BDNF…
View article: The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment
The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment Open
Background Auditory verbal hallucinations (AVH) are a core symptom of schizophrenia. Low-frequency (e.g., 1 Hz) repetitive transcranial magnetic stimulation (rTMS) targeting language processing regions (e.g., left TPJ) has been evident as …
View article: IL-17 and TNF-β: Predictive biomarkers for transition to psychosis in ultra-high risk individuals
IL-17 and TNF-β: Predictive biomarkers for transition to psychosis in ultra-high risk individuals Open
Background Dysregulation of immunity, such as levels of inflammatory factors, has been regarded as a sign of schizophrenia. Changes in cytokine levels are not only described in the early onset of disease, but also observed in ultra-high ri…
View article: Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia
Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia Open
View article: Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis Open
View article: Abnormal Brain Network Interaction Associated With Positive Symptoms in Drug-Naive Patients With First-Episode Schizophrenia
Abnormal Brain Network Interaction Associated With Positive Symptoms in Drug-Naive Patients With First-Episode Schizophrenia Open
Positive symptoms are marked features of schizophrenia, and emerging evidence has suggested that abnormalities of the brain network underlying these symptoms may play a crucial role in the pathophysiology of the disease. We constructed two…
View article: Differences in Cortical Thickness in Schizophrenia Patients With and Without Auditory Verbal Hallucinations
Differences in Cortical Thickness in Schizophrenia Patients With and Without Auditory Verbal Hallucinations Open
Auditory verbal hallucinations (AVHs) are one of the most common and severe symptoms of schizophrenia (SCZ), but the neuroanatomical mechanisms underlying AVHs remain unclear. This study aimed to investigate whether persistent AVHs (pAVH) …
View article: Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: a 1H MRS study
Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: a 1H MRS study Open
Studies of schizophrenia (SCZ) have associated auditory verbal hallucinations (AVH) with structural and functional abnormalities in frontal cortex, especially medial prefrontal cortex (mPFC). Although abnormal prefrontal network connectivi…