Explanipedia

Chelerythrine inhibits esophageal squamous cell carcinoma progression via PINK1-Parkin-mediated mitophagy Open

Yijian Zhou, Zhuo Wang, Hongzhou Zhao, Yongpan Liu, Yong Lin , et al. · 2025

Identification of a distinct epigenetic subgroup with inferior PFS in intracranial mesenchymal tumors with FET::CREB fusion Open

Yong Lin, Yun Ning, Lan Yang, Yan Cao, Ruijiao Zhao , et al. · 2025

Intracranial mesenchymal tumors (IMTs) with FET::CREB fusion are newly recognized molecular entities, provisionally classified into subgroups A and B. Although Group B has been partially characterized, the clinicopathological and molecular…

Road Density Shapes Soil Fungal Community Composition in Urban Road Green Space Open

Shuhong Luo, Yong Lin, Ruirui Chen, Jigang Han, Yan Liu · 2025

Road density is a key indicator of human activity, causing habitat loss and fragmentation. Soil fungi, essential for ecosystem functioning, are sensitive bioindicators. Yet their responses to road density in urban green spaces are poorly c…

Cost-effectiveness analysis of oral antiviral therapy in patients with indeterminate chronic hepatitis B infection Open

H. Zhuo, Yong Lin, Huiwen Song, Mei‐Zhu Hong, Lei Yao , et al. · 2025

Oral AVT for IP-CHB is highly cost-effective and significantly reduces the global burden of hepatitis B virus (HBV)-related diseases and mortality.

Effects of astaxanthin on growth performance, intestinal integrity, and microbiota in Salmonella Enteritidis-infected chickens Open

Yong Lin, Jiansen Gong, Colin Buttimer, Xiaoqing Pan, Yimin Jia , et al. · 2025

This study investigated the effects of astaxanthin (AST) supplementation in drinking water on the growth performance, intestinal barrier function, and cecal microbiota of broilers challenged with Salmonella Enteritidis. During the 20-day e…

Amphisome plays a role in HBV production and release through the endosomal and autophagic pathways Open

Jia Li, Thekla Kemper, Ruth Broering, Yong Lin, Xueyu Wang , et al. · 2025

Background: Autophagic and endosomal pathways coordinately contribute to HBV virions and subviral particles (SVPs) production. To date, limited evidence supports that HBV and exosomes have a common pathway for their biogenesis and secretio…

A predictive model for functional cure in chronic HBV patients treated with pegylated interferon alpha: a comparative study of multiple algorithms based on clinical data Open

Yunbin Ye, Yong Lin, Fang Sun, Wenyan Yang, Lina Zhou , et al. · 2024

The combined use of the baseline log₂(HBsAg) value, HBsAg decline rate at week 12, gender, neutrophil count at week 12, and age can serve as a foundational predicting model for anticipating the clearance of HBsAg in individuals …

Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin Open

Binli Mao, Vu Thuy Khanh Le‐Trilling, Haoran Tang, Jie Hu, M Schmitz , et al. · 2024

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic, posing serious threats to global health. Effective broad-spectrum antiviral drugs for the treatment of COVID-19 are n…

304 - Endoscopic combined robotic-assisted excision of symptomatic prostatic utricle cyst Open

Liu P, Yong Lin, Yongsheng Ou, Liyuan Huang, Weihao Weng , et al. · 2024

Agaricus blazei murrill and Enteromorpha prolifera-derived polysaccharides gain therapeutic effects on esophageal squamous cell carcinoma Open

Yong Lin, Xinxin Li, Jing Zhao, Penghu Liu, Yijian Zhou , et al. · 2024

Esophageal squamous cell carcinoma (ESCC), the most common pathological type of esophageal cancer, is one of the leading causes of cancer death worldwide, but an effective therapeutic avenue is still absent. This study was to evaluate the …

Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release Open

Jia Li, Yong Lin, Xueyu Wang, Mengji Lu · 2024

Hepatitis B virus (HBV) produces and releases various particle types, including complete virions, subviral particles with envelope proteins, and naked capsids. Recent studies demonstrate that HBV exploits distinct intracellular membrane tr…

Noninvasive models to diagnose liver histology in HBeAg-negative chronic hepatitis B Open

Yamei Ye, Lina Zhou, Fang Sun, Wenyang Yang, Chun Lin , et al. · 2023

Introduction and objectives : Noninvasive, practical, and convenient means of assessment of liver histology in China are greatly needed.This research was to develop precise non-invasive tests to assess the histological activity grade and t…

Association of the dietary inflammation index (DII) with the prevalence of chronic kidney disease in patients with type-2 diabetes mellitus Open

Chun‐Hua Guo, Yong Lin, Senchao Wu, Huaqing Li, Meng Wu , et al. · 2023

Chronic kidney disease (CKD) is a major complication of diabetes mellitus (DM). Inflammation is an essential component in the process of CKD progression in patients with DM. Diet is a significant determinant of systemic inflammation levels…

Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma Open

Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang , et al. · 2023

Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways Open

Zhenyu Zhao, Zhen Wei, Jiaxin Zheng, Zhihong Li, Hecun Zou , et al. · 2023

Chronic hepatitis B virus (HBV) infection remains one of the major global public health concerns, and it develop into liver fibrosis, cirrhosis, and hepatocellular carcinoma. Recent evidence suggests that endosomal and autophagic vesicles …

The roles of the SOX2 protein in the development of esophagus and esophageal squamous cell carcinoma, and pharmacological target for therapy Open

Jiaying Zhang, Zhuo Wang, Hongzhou Zhao, Yuxuan Wei, Yijian Zhou , et al. · 2023

SOX2 is a transcription factor belonging to the SOX gene family, whose activity has been associated with the maintenance of the stemness and self-renewal of embryonic stem cells (ESCs), as well as the induction of differentiated cells into…

Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy Open

Anqi Tang, Yu Zhang, Ling Wu, Yong Lin, Lizeyu Lv , et al. · 2023

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti-aging properties and has been shown to delay the onset…

Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions Open

Jiaxin Zheng, Yingying Deng, Zhen Wei, Hecun Zou, Xiang Wen , et al. · 2023

Phosphatidylinositol lipids play vital roles in lipid signal transduction, membrane recognition, vesicle transport, and viral replication. Previous studies have revealed that SAC1-like phosphatidylinositol phosphatase (SACM1L/SAC1), which …

Encapsulated Essential Oils Improve the Growth Performance of Meat Ducks by Enhancing Intestinal Morphology, Barrier Function, Antioxidant Capacity and the Cecal Microbiota Open

Hongduo Bao, Yongqiang Xue, Yingying Zhang, Feng Tu, Ran Wang , et al. · 2023

The objective of this study was to evaluate the effects of encapsulated essential oils (EOs) on the gut microbiota, growth performance, intestinal morphology, antioxidant properties and barrier function of meat-type ducks. A total of 320 m…

HBV sL13H mutation impairs its surface antigen expression and ability to induce autophagy Open

Jianbo Xia, Liang Cao, Zhenyu Zhao, Yingying Deng, Mengji Lu , et al. · 2022

Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization Open

Zhuang Li, Wenjuan Fu, Xiaohong Chen, Shuai Wang, Ru-Song Deng , et al. · 2022

Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell lines Open

Fahong Li, Yingying Deng, Shenyan Zhang, Beidi Zhu, Jun Wang , et al. · 2022

Previous studies have revealed multiple tissue- or cell-specific or enriched miRNA profiles. However, miRNA profiles enriched in hepatic cell types and their effect on HBV replication have not been well elucidated. In this study, primary h…

Towards robust immune responses after heterologous COVID-19 vaccination and its application perspectives Open

Yong Lin, Ailong Huang · 2022

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1], has seriously impacted the global health and economy.Effective vaccination, with homologous or heterologous prime…

Personal Information Protection and Interest Balance Based on Rational Expectation in the Era of Big Data Open

Yong Lin, Zhenjiang Shen, Xiao Teng · 2022

In the era of big data, personal information has been widely shared and used, which facilitates personal life, social production and public management but also brings the risk of personal information abuse.Personal information has multiple…

Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro Open

Binli Mao, Vu Thuy Khanh Le‐Trilling, Kai Wang, Denise Mennerich, Jie Hu , et al. · 2022

Coronavirus disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has set off a global pandemic. There is an urgent unmet need for safe, affordable, and effective therapeu…

Towards robust immune responses after heterologous COVID-19 vaccination and its application perspectives Open

Yong Lin, Ailong Huang · 2022

Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects Open

Jiaxin Zheng, Yingying Deng, Zhenyu Zhao, Binli Mao, Mengji Lu , et al. · 2021

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic that poses a great threat to human health worldwide. As the humoral immune response plays essential roles i…

Endoplasmic reticulum stress promotes HBV production by enhancing use of the autophagosome/multivesicular body axis Open

Xueyu Wang, Zhiqiang Wei, Bin Cheng, Jia Li, Yulin He , et al. · 2021

Background and Aims HBV infection has been reported to trigger endoplasmic reticulum (ER) stress and initiate autophagy. However, how ER stress and autophagy influence HBV production remains elusive. Here, we studied the effect of tunicamy…

Characterization of Specific Humoral Immunity in Asymptomatic SARS-CoV-2 Infection Open

Yingying Deng, Jiaxin Zheng, Yong Lin, Ailong Huang · 2021

The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in December 2019 caused a huge blow to both global public health and global economy. At the early stage of the coronavirus disease 2019 (COVID-19) e…

CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation Open

Xueyu Wang, Zhiqiang Wei, Tingyu Lan, Yulin He, Bin Cheng , et al. · 2021

Hepatitis B virus (HBV) particles are thought to be secreted from hepatocytes through multivesicular bodies (MVBs); however, the cellular trafficking mechanisms prior to this process remain elusive. It has been reported that CCDC88A/GIV ex…

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