Yunzhan Zhang
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View article: Role of CDH1 gene variants and E-cadherin localization in gastric mucosal cancerization
Role of CDH1 gene variants and E-cadherin localization in gastric mucosal cancerization Open
Background This study investigates the role of CDH1 gene single nucleotide polymorphisms (SNPs), mRNA transcription levels, and E-cadherin protein localization in Helicobacter pylori (Hp)-associated gastric diseases and their contribution …
View article: Association of miR-499 rs3746444, miR-149 rs2292832 polymorphisms and their expression levels with helicobacter pylori-related gastric diseases and Traditional Chinese Medicine syndromes.
Association of miR-499 rs3746444, miR-149 rs2292832 polymorphisms and their expression levels with helicobacter pylori-related gastric diseases and Traditional Chinese Medicine syndromes. Open
The C allele of miR-149 rs2292832 may be a protective factor for gastric mucosal atrophy. H. pylori may participate in the evolution of benign to malignant gastric mucosa lesions by inducing the overexpression of miR-499 and down regulatio…
View article: Functional gene polymorphisms and expression alteration of selected microRNAs and the risk of various gastric lesions in Helicobacter pylori-related gastric diseases
Functional gene polymorphisms and expression alteration of selected microRNAs and the risk of various gastric lesions in Helicobacter pylori-related gastric diseases Open
Background: Helicobacter pylori (Hp) persistent infection is an important pathogenic factor for a series of chronic gastric diseases from chronic gastritis to gastric cancer. Genetic and epigenetic abnormalities of microRNAs may play a vit…
View article: The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome
The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome Open
Aims. The study aims to explore the effects of the single-nucleotide polymorphism of miR-27a and its expression in Helicobacter pylori (H. pylori)-related diseases and the relationship between gastric pathology and traditional Chinese medi…
View article: RNA-binding protein HuR regulates translation of vitamin D receptor modulating rapid epithelial restitution after wounding
RNA-binding protein HuR regulates translation of vitamin D receptor modulating rapid epithelial restitution after wounding Open
Homeostasis of the intestinal epithelium is tightly regulated by numerous extracellular and intracellular factors including vitamin D and the vitamin D receptor (VDR). VDR is highly expressed in the intestinal epithelium and is implicated …
View article: Associations of Interleukin‐1<i>β</i> with <i>H. pylori</i>‐Induced Gastric Atrophy and Syndrome of Dampness‐Heat in the Spleen and Stomach in Subjects with <i>H. pylori</i>‐Related Gastric Diseases
Associations of Interleukin‐1<i>β</i> with <i>H. pylori</i>‐Induced Gastric Atrophy and Syndrome of Dampness‐Heat in the Spleen and Stomach in Subjects with <i>H. pylori</i>‐Related Gastric Diseases Open
H. pylori ‐related gastric diseases (HPGD) are a series of gastric mucosal benign and malignant lesions associated with H. pylori infection. Exploring the pathogenesis of HPGD will be of great significance to prevent and treat gastric mali…
View article: Interaction of Cyclooxygenase‐2 with <i>Helicobacter pylori</i> Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in <i>Helicobacter pylori</i>‐Related Gastric Diseases
Interaction of Cyclooxygenase‐2 with <i>Helicobacter pylori</i> Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in <i>Helicobacter pylori</i>‐Related Gastric Diseases Open
Cyclooxygenase‐2 (COX‐2) is an inducible enzyme stimulated by various inflammatory factors (IFs). Chronic gastritis is a classic model of “inflammation‐cancer transformation” and Helicobacter pylori ‐related gastric diseases (HPGD) are spe…
View article: Efficacy of Jianpi Liqi therapy for functional dyspepsia
Efficacy of Jianpi Liqi therapy for functional dyspepsia Open
Background: We performed this meta-analysis to assess the efficacy and safety of Jianpi Liqi therapy (JLT), a traditional Chinese medicine therapy, in treating functional dyspepsia (FD). Methods: We systematically searched 13 databases fro…
View article: Regulation of Intestinal Epithelial Barrier Function by Long Noncoding RNA <i>uc.173</i> through Interaction with MicroRNA 29b
Regulation of Intestinal Epithelial Barrier Function by Long Noncoding RNA <i>uc.173</i> through Interaction with MicroRNA 29b Open
The mammalian intestinal epithelium establishes a selectively permeable barrier that supports nutrient absorption and prevents intrusion by noxious luminal substances and microbiota. The effectiveness and integrity of the barrier function …
View article: Efficacy and safety of Modified Tongxie Yaofang in diarrhea-predominant irritable bowel syndrome management: A meta-analysis of randomized, positive medicine-controlled trials
Efficacy and safety of Modified Tongxie Yaofang in diarrhea-predominant irritable bowel syndrome management: A meta-analysis of randomized, positive medicine-controlled trials Open
This meta-analysis indicated that M-TXYF could be a promising Chinese herbal formula in treating IBS-D. However, considering the lack of higher quality of randomized controlled trials (RCTs), highly believable evidences should be required.
View article: Systematic review and meta-analysis of traditional Chinese medicine in the treatment of constipation-predominant irritable bowel syndrome
Systematic review and meta-analysis of traditional Chinese medicine in the treatment of constipation-predominant irritable bowel syndrome Open
TCM showed greater improvement in terms of clinical efficacy in the treatment of IBS-C than cisapride and mosapride, although it was not possible to draw a definitive conclusion due to the small sample size, high risk, and low quality of t…
View article: Interleukin-12 and interferon-γ acting on damp-heat of spleen-stomach syndrome triggered by helicobacter pylori
Interleukin-12 and interferon-γ acting on damp-heat of spleen-stomach syndrome triggered by helicobacter pylori Open
Our findings suggest that IL-12 and IFN-γ are involved in DHSS pathology, but not in SQD, acting as healthy-Qi. DHSS is not just the consequence of those two cytokines but results from the cross-talk between a number of cytokines and/or ot…
View article: Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta‐Analysis
Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta‐Analysis Open
Modified Banxia Xiexin decoction (MBXD) is a classical Chinese herbal formula in treating gastroesophageal reflux disease (GERD) for long time, but the efficacy of it is still controversial. This study is to evaluate the efficacy and safet…