Yupei Zhao
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View article: A Robust Solar Evaporator with Hierarchical Architecture for Ultrahigh Efficiency and Large‐Scale Zero‐Liquid‐Discharge Desalination
A Robust Solar Evaporator with Hierarchical Architecture for Ultrahigh Efficiency and Large‐Scale Zero‐Liquid‐Discharge Desalination Open
Solar‐driven desalination offers a green and sustainable strategy for solving the issue of freshwater scarcity. However, it remains a challenge to develop a robust evaporator via an eco‐friendly strategy, capable of resolving the long‐stan…
View article: Novel paradigms in KRAS targeting: Unveiling strategies to combat drug resistance
Novel paradigms in KRAS targeting: Unveiling strategies to combat drug resistance Open
The Kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutation is one of the most prevalent activating alterations in cancer. It indicates a poor overall prognosis due to its highly invasive nature. Although several KRAS inhibitors have …
View article: Dynamic Frequency Feature Fusion Network for Multi-Source Remote Sensing Data Classification
Dynamic Frequency Feature Fusion Network for Multi-Source Remote Sensing Data Classification Open
Multi-source data classification is a critical yet challenging task for remote sensing image interpretation. Existing methods lack adaptability to diverse land cover types when modeling frequency domain features. To this end, we propose a …
View article: FOLR2+ macrophages in cancer: allies or enemies
FOLR2+ macrophages in cancer: allies or enemies Open
View article: Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway’s role in shaping the immunosuppressive environment of lung adenocarcinoma
Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway’s role in shaping the immunosuppressive environment of lung adenocarcinoma Open
Objectives The tumor microenvironment (TME) plays a critical role in the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular composition of the TME in LUAD and assess the role of the MDK-NCL signaling pat…
View article: Emerging pathological diagnostic strategies for solid pseudopapillary neoplasm of the pancreas: insights from omics and innovative techniques
Emerging pathological diagnostic strategies for solid pseudopapillary neoplasm of the pancreas: insights from omics and innovative techniques Open
Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low‐grade malignant tumor, representing 0.9–2.7% of all exocrine pancreatic tumors. SPN patients generally have a favorable prognosis with a 5‐year survival rate exceeding 95%…
View article: Warehouse Prediction and Planning Based on K-MEANS Algorithm and GA-LSTM
Warehouse Prediction and Planning Based on K-MEANS Algorithm and GA-LSTM Open
The purpose of this paper is to study warehouse prediction and planning based on K-means algorithm and GA-LSTM through data analysis and deep learning methods. Firstly, this paper utilizes the inventory and daily sales data and uses K-mean…
View article: Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies
Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies Open
Transcriptional dysregulation is a hallmark of cancer initiation and progression, driven by genetic and epigenetic alterations. Enhancer reprogramming has emerged as a pivotal driver of carcinogenesis, with cancer cells often relying on ab…
View article: Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status
Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status Open
The pancreas, an organ with dual functions, regulates blood glucose levels through the endocrine system by secreting hormones such as insulin and glucagon. It also aids digestion through the exocrine system by secreting digestive enzymes. …
View article: Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer
Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer Open
View article: RNA binding protein Pumilio2 promotes chemoresistance of pancreatic cancer via focal adhesion pathway and interacting with transcription factor EGR1
RNA binding protein Pumilio2 promotes chemoresistance of pancreatic cancer via focal adhesion pathway and interacting with transcription factor EGR1 Open
Background Pancreatic cancer (PC) has insidious onset, high malignancy and poor prognosis. Gemcitabine (GEM) is one of the first-line chemotherapy drugs for PC. However, resistance for GEM has always been a bottleneck problem leading to re…
View article: Long-term Outcomes of Surgical Treatment for Pancreatic Neuroendocrine Neoplasm With Synchronous Hepatic Metastasis
Long-term Outcomes of Surgical Treatment for Pancreatic Neuroendocrine Neoplasm With Synchronous Hepatic Metastasis Open
Objective To evaluate surgical impact on the overall survival (OS) of pancreatic neuroendocrine neoplasm (pNEN) with synchronous hepatic metastases (sHMs). Methods A total of 163 pNEN-sHM patients were recruited from 3 institutions in Chin…
View article: Phase II Trial of Enfortumab Vedotin in Patients With Previously Treated Advanced Head and Neck Cancer
Phase II Trial of Enfortumab Vedotin in Patients With Previously Treated Advanced Head and Neck Cancer Open
PURPOSE Despite advances in immunotherapy, unresectable recurrent/metastatic head and neck cancer (HNC) carries a poor prognosis, and effective treatments are needed. As nectin-4 is widely expressed in HNC, enfortumab vedotin (EV), a necti…
View article: Integrated analysis of microbiome and metabolome reveals signatures in PDAC tumorigenesis and prognosis
Integrated analysis of microbiome and metabolome reveals signatures in PDAC tumorigenesis and prognosis Open
Pancreatic cancer, predominantly pancreatic ductal adenocarcinoma (PDAC), is one of the most malignant tumors of the digestive system. Emerging evidence suggests the involvement of the microbiome and metabolic substances in the development…
View article: CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment
CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment Open
View article: Construction of a novel model based on PVT1-MYC duet-related genes for predicting survival and characterization of the tumor microenvironment in pancreatic cancer
Construction of a novel model based on PVT1-MYC duet-related genes for predicting survival and characterization of the tumor microenvironment in pancreatic cancer Open
Pancreatic cancer is an extremely malignant tumor. PVT1 and MYC signaling has been considered as a therapeutic target recently. Nonetheless, the prognostic values and critical regulatory networks of PVT1-MYC duet in pancreatic cancer remai…
View article: Extracellular vesicles miR‐31‐5p promotes pancreatic cancer chemoresistance via regulating LATS2‐Hippo pathway and promoting SPARC secretion from pancreatic stellate cells
Extracellular vesicles miR‐31‐5p promotes pancreatic cancer chemoresistance via regulating LATS2‐Hippo pathway and promoting SPARC secretion from pancreatic stellate cells Open
Pancreatic cancer remains one of the most lethal malignant diseases. Gemcitabine‐based chemotherapy is still one of the first‐line systemic treatments, but chemoresistance occurs in the majority of patients. Recently, accumulated evidence …
View article: Lymphocyte-to-Monocyte Ratio Predicts Survival for Intraductal Papillary Mucinous Neoplasm with Associated Invasive Carcinoma of the Pancreas: Results from a High-Volume Center
Lymphocyte-to-Monocyte Ratio Predicts Survival for Intraductal Papillary Mucinous Neoplasm with Associated Invasive Carcinoma of the Pancreas: Results from a High-Volume Center Open
Introduction: Intraductal papillary mucinous neoplasm (IPMN) is an important precursor lesion of pancreatic cancer. Systemic inflammatory parameters are widely used in the prognosis prediction of cancer; however, their prognostic implicati…
View article: Histone lactylation dynamics: Unlocking the triad of metabolism, epigenetics, and immune regulation in metastatic cascade of pancreatic cancer
Histone lactylation dynamics: Unlocking the triad of metabolism, epigenetics, and immune regulation in metastatic cascade of pancreatic cancer Open
Cancer cells rewire metabolism to sculpt the immune tumor microenvironment (TME) and propel tumor advancement, which intricately tied to post-translational modifications. Histone lactylation has emerged as a novel player in modulating prot…
View article: Microbiota-metabolism-epigenetics-immunity axis in cancer
Microbiota-metabolism-epigenetics-immunity axis in cancer Open
Citation: Ren B, Fang Y, Gu M, You L, Zhang T and Zhao Y (2024) Microbiota-metabolism-epigenetics-immunity axis in cancer. Front. Immunol. 15:1449912. doi: 10.3389/fimmu.2024.1449912
View article: Unbiasedly decoding the tumor microenvironment with single-cell multiomics analysis in pancreatic cancer
Unbiasedly decoding the tumor microenvironment with single-cell multiomics analysis in pancreatic cancer Open
View article: Multiomics integration reveals NETosis heterogeneity and TLR2 as a prognostic biomarker in pancreatic cancer
Multiomics integration reveals NETosis heterogeneity and TLR2 as a prognostic biomarker in pancreatic cancer Open
View article: Comprehensive analysis of bulk and single-cell transcriptomic data reveals a novel signature associated with endoplasmic reticulum stress, lipid metabolism, and liver metastasis in pancreatic cancer
Comprehensive analysis of bulk and single-cell transcriptomic data reveals a novel signature associated with endoplasmic reticulum stress, lipid metabolism, and liver metastasis in pancreatic cancer Open
View article: Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors
Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors Open
The World Health Organization (WHO) 2017 classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly …
View article: ABCD1 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm of the Pancreas
ABCD1 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm of the Pancreas Open
The diagnosis of solid pseudopapillary neoplasm of the pancreas (SPN) can be challenging due to potential confusion with other pancreatic neoplasms, particularly pancreatic neuroendocrine tumors (NETs), using current pathological diagnosti…
View article: Preoperative pancreatic stent placement before the enucleation of insulinoma located in the head and neck of the pancreas in proximity to the main pancreatic duct: study protocol for a multicentre randomised clinical trial in Chinese tertiary medical centres
Preoperative pancreatic stent placement before the enucleation of insulinoma located in the head and neck of the pancreas in proximity to the main pancreatic duct: study protocol for a multicentre randomised clinical trial in Chinese tertiary medical centres Open
Introduction The surgical intervention approach to insulinomas in proximity to the main pancreatic duct remains controversial. Standard pancreatic resection is recommended by several guidelines; however, enucleation (EN) still attracts sur…
View article: Immune-related signature identifies IL1R2 as an immunological and prognostic biomarker in pancreatic cancer
Immune-related signature identifies IL1R2 as an immunological and prognostic biomarker in pancreatic cancer Open
Objective: Pancreatic cancer is one of the most aggressive malignancies, a robust prognostic signature and novel biomarkers are urgently needed for accurate stratification of the patients and optimization of clinical decision-making. Metho…
View article: Epigenetic regulation in cancer
Epigenetic regulation in cancer Open
Epigenetic modifications are defined as heritable changes in gene activity that do not involve changes in the underlying DNA sequence. The oncogenic process is driven by the accumulation of alterations that impact genome's structure and fu…
View article: International consensus guidelines on robotic pancreatic surgery in 2023
International consensus guidelines on robotic pancreatic surgery in 2023 Open
The international RPS guidelines can guide current practice for surgeons, patients, medical societies, hospital administrators, and related social communities. Further randomized trials are required to determine the added value of RPS as c…
View article: EP11.02-04 Efficacy and Safety of Camrelizumab plus Famitinib in Previously Treated Patients with Advanced Non Small Cell Lung Cancer
EP11.02-04 Efficacy and Safety of Camrelizumab plus Famitinib in Previously Treated Patients with Advanced Non Small Cell Lung Cancer Open