Yuping Cai
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View article: Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity Open
Itaconate accumulates and manifests antibacterial activity in macrophages upon bacterial infection. Convincing evidence substantiates that itaconate transports across the plasma membrane and vacuolar membrane. But the molecular bases under…
View article: Programmable Artificial Glucose-sensing Receptor for Autonomous Single-Cell Closed-loop Glycemic Control
Programmable Artificial Glucose-sensing Receptor for Autonomous Single-Cell Closed-loop Glycemic Control Open
Synthetic receptors enable programmable cellular functions, but their metabolism-regulating applications remain underexplored. Current synthetic cell strategies for glycemic control mimic pancreatic β-cell glucose-responsive insulin output…
View article: Targeted next-generation sequencing for pathogen detection and epidemiological analysis of pediatric acute respiratory infections in Xiantao, China
Targeted next-generation sequencing for pathogen detection and epidemiological analysis of pediatric acute respiratory infections in Xiantao, China Open
tNGS provides rapid, comprehensive pathogen identification in pediatric ARIs while uncovering intricate co-infection patterns. The findings highlight the importance of age-specific and seasonal considerations in managing respiratory infect…
View article: RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation
RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation Open
The capacity of cells to sense and respond to nutrient availability is essential for metabolic homeostasis. Failure in this process may cause cell death and associated diseases. While nutrient sensing in metabolic pathways is well understo…
View article: Charting unknown metabolic reactions by mass spectrometry-resolved stable-isotope tracing metabolomics
Charting unknown metabolic reactions by mass spectrometry-resolved stable-isotope tracing metabolomics Open
View article: Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents
Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents Open
Our findings highlight that gut microbiota alterations contribute to AAs deficiency, particularly lysine, which plays a crucial role in MDD pathogenesis in children and adolescents. Targeting AA metabolism may offer novel therapeutic strat…
View article: S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer
S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer Open
View article: Plasma metabolomics reveals the shared and distinct metabolic disturbances associated with cardiovascular events in coronary artery disease
Plasma metabolomics reveals the shared and distinct metabolic disturbances associated with cardiovascular events in coronary artery disease Open
View article: Identifying plasma metabolic characteristics of major depressive disorder, bipolar disorder, and schizophrenia in adolescents
Identifying plasma metabolic characteristics of major depressive disorder, bipolar disorder, and schizophrenia in adolescents Open
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are classified as major mental disorders and together account for the second-highest global disease burden, and half of these patients experience symptom onset…
View article: Purine salvage–associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model–based study
Purine salvage–associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model–based study Open
Esophageal squamous cell carcinoma (ESCC) remains an important health concern in developing countries. Patients with advanced ESCC have a poor prognosis and survival rate, and achieving early diagnosis remains a challenge. Metabolic biomar…
View article: Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study Open
This study identified novel relationships between urinary paraben concentrations and diet-related metabolites but not with metabolites on endocrine-disrupting pathways, as hypothesized. It demonstrates the feasibility of integrating untarg…
View article: A study on computer vision for facial emotion recognition
A study on computer vision for facial emotion recognition Open
Artificial intelligence has been successfully applied in various fields, one of which is computer vision. In this study, a deep neural network (DNN) was adopted for Facial emotion recognition (FER). One of the objectives in this study is t…
View article: Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations
Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations Open
View article: Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations
Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations Open
Aberrant tumor metabolism is a hallmark of cancer in which metabolic rewiring can support tumor growth under nutrient deficient conditions. KRAS mutations occur in 35-45% of all colorectal cancer (CRC) cases and are difficult to treat. The…
View article: Publisher Correction: Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer
Publisher Correction: Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer Open
View article: Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer
Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer Open
View article: Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking Open
View article: Bile acid distributions, sex-specificity, and prognosis in colorectal cancer
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer Open
Background Bile acids are known to be genotoxic and contribute to colorectal cancer (CRC). However, the link between CRC tumor bile acids to tumor location, patient sex, microbiome, immune-regulatory cells, and prognosis is not clear. Meth…
View article: NMR and HRMS raw data for "Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking"
NMR and HRMS raw data for "Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking" Open
Raw NMR data and HRMS data for synthesized compounds
View article: NMR and HRMS raw data for "Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking"
NMR and HRMS raw data for "Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking" Open
Raw NMR data and HRMS data for synthesized compounds
View article: Supplementary Data - Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer network
Supplementary Data - Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer network Open
Supplementary data 1: Peak annotation evaluation between MetDNA1 and KGMN (MetDNA2) Supplementary data 2: 46 standard mixture (46std_mix) and the knowledge-based metabolic reaction network Suppleme…
View article: Supplementary Data - Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer network
Supplementary Data - Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer network Open
Supplementary data 1: Peak annotation evaluation between MetDNA1 and KGMN (MetDNA2) Supplementary data 2: 46 standard mixture (46std_mix) and the knowledge-based metabolic reaction network Suppleme…
View article: Supplementary Data - Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer network
Supplementary Data - Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer network Open
Supplementary data 1: Peak annotation evaluation between MetDNA1 and KGMN (MetDNA2) Supplementary data 2: 46 standard mixture (46std_mix) and the knowledge-based metabolic reaction network Suppleme…
View article: Supplementary Data - Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer network
Supplementary Data - Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer network Open
Supplementary data 1: Peak annotation evaluation between MetDNA1 and KGMN (MetDNA2) Supplementary data 2: 46 standard mixture (46std_mix) and the knowledge-based metabolic reaction network Suppleme…
View article: Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila
Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila Open
System-wide metabolic homeostasis is crucial for maintaining physiological functions of living organisms. Stable-isotope tracing metabolomics allows to unravel metabolic activity quantitatively by measuring the isotopically labeled metabol…
View article: Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic network
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic network Open
Liquid chromatography - mass spectrometry (LC-MS) based untargeted metabolomics allows to measure both known and unknown metabolites in the metabolome. However, unknown metabolite annotation is a grand challenge in untargeted metabolomics.…
View article: Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study
Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study Open
The interplay between the sex-specific differences in tumor metabolome and colorectal cancer (CRC) prognosis has never been studied and represents an opportunity to improve patient outcomes. This study examines the link between tumor metab…
View article: Topology Identification of the Hindmarsh-Rose Model via Deterministic Learning
Topology Identification of the Hindmarsh-Rose Model via Deterministic Learning Open
In this paper, the complex dynamic behavior of the Hindmarsh-Rose (HR) model which characterizes the neuron cell is analyzed numerically. And the unknown topology of the system in dynamic environment is locally accurately identified based …
View article: Additional file 2 of Bile acid distributions, sex-specificity, and prognosis in colorectal cancer
Additional file 2 of Bile acid distributions, sex-specificity, and prognosis in colorectal cancer Open
Additional file 2: Table S3. Statistics of the abundances of bacteria in tumors from RCCs and LCCs.
View article: Additional file 4 of Bile acid distributions, sex-specificity, and prognosis in colorectal cancer
Additional file 4 of Bile acid distributions, sex-specificity, and prognosis in colorectal cancer Open
Additional file 4. Clinical information and bile acid values (dichotomized by medians) of individual patients.