YuHong Fu
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View article: Dysregulation of SELENOI Is Associated with TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis
Dysregulation of SELENOI Is Associated with TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis Open
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by progressive degeneration of motor neurons and accumulation of TAR DNA-binding protein 43 (TDP-43) in the brain. Increasing evidence indicates that…
View article: Distinct <scp>AQP4</scp> Alterations in Movement Disorders with Primary Synucleinopathy
Distinct <span>AQP4</span> Alterations in Movement Disorders with Primary Synucleinopathy Open
Background Aquaporin‐4 (AQP4) is involved in clearing amyloidogenic proteins, but it remains unexplored how it is comparatively altered in neuron‐ and oligodendrocyte‐predominant synucleinopathies. Objective The aim was to assess AQP4 prot…
View article: Author response: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Author response: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration Open
View article: Standardised TruAI Automated Quantification of Intracellular Neuromelanin Granules in Human Brain Tissue Sections
Standardised TruAI Automated Quantification of Intracellular Neuromelanin Granules in Human Brain Tissue Sections Open
Aims To standardise and automate the quantitation of human‐unique neuromelanin granules in catecholamine neurons in post‐mortem tissue sections from healthy individuals at different ages to understand any changes in these granules with age…
View article: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration Open
Parkinson’s disease (PD) is characterized by the death of substantia nigra pars compacta (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is li…
View article: Mechanistic Study of Citrate Affecting the Adsorption of Gold Nanoparticles by Goethite
Mechanistic Study of Citrate Affecting the Adsorption of Gold Nanoparticles by Goethite Open
The mechanism of regulating the interfacial behavior of gold nanoparticles (AuNPs) in environmental media is key to assessing their ecological risks. In this study, we break through the traditional one-factor adsorption research model and …
View article: Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy
Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy Open
Background Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed of α‐synuclein aggregates. In Parkinson's disease, increases in monounsatur…
View article: Neuromelanin and selective neuronal vulnerability to Parkinson’s disease
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease Open
Neuromelanin is a unique pigment made by some human catecholamine neurons. These neurons survive with their neuromelanin content for a lifetime but can also be affected by age-related neurodegenerative conditions, as observed using new neu…
View article: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration Open
Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is likely altered i…
View article: Author response: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Author response: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration Open
View article: HippoMM: Hippocampal-inspired Multimodal Memory for Long Audiovisual Event Understanding
HippoMM: Hippocampal-inspired Multimodal Memory for Long Audiovisual Event Understanding Open
Comprehending extended audiovisual experiences remains a fundamental challenge for computational systems. Current approaches struggle with temporal integration and cross-modal associations that humans accomplish effortlessly through hippoc…
View article: Overexpression of α–synuclein in Midbrain Dopamine Neurons Reduces Dopamine Release Without Cell Loss and Drives Mild Motor Deficits in Mice
Overexpression of α–synuclein in Midbrain Dopamine Neurons Reduces Dopamine Release Without Cell Loss and Drives Mild Motor Deficits in Mice Open
It has proven challenging to faithfully recapitulate the key pathological, physiological, and behavioral features of Parkinson’s Disease (PD) in animals. Here we used adeno-associated virus (AAV) vectors to achieve cell type-specific overe…
View article: Standardised TruAI automated quantification of intracellular neuromelanin granules in human brain tissue sections
Standardised TruAI automated quantification of intracellular neuromelanin granules in human brain tissue sections Open
Aims To standardise and automate the quantitation of human-unique neuromelanin granules in catecholamine neurons in post-mortem tissue sections from healthy individuals at different ages to understand any changes in these granules with age…
View article: Human Endogenous Retrovirus K in Astrocytes Is Altered in Parkinson's Disease
Human Endogenous Retrovirus K in Astrocytes Is Altered in Parkinson's Disease Open
Background Parkinson's disease (PD) is the most common neurodegenerative movement disease. Human endogenous retroviruses (HERVs) are proviral remnants of ancient retroviral infection of germ cells that now constitute about 8% of the human …
View article: Optimisation of Embodied Carbon and Thermal Performance of Roof Material Selections for Australian Residential Housing
Optimisation of Embodied Carbon and Thermal Performance of Roof Material Selections for Australian Residential Housing Open
This research is responding to the latest sustainable development policy for residential housing in Australia, which mandates a minimum R6.0 for roof insulation and a requirement of reporting the embodied carbon footprint for new build res…
View article: Multifunctional Trilayer Films Based on Gelatin-Dextran Incorporated with Defatted Rice Bran-Derived Carbon Dots for Scallop Preservation
Multifunctional Trilayer Films Based on Gelatin-Dextran Incorporated with Defatted Rice Bran-Derived Carbon Dots for Scallop Preservation Open
View article: Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model
Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model Open
View article: MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity
MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity Open
View article: The Role of Alpha-Synuclein Pathology
The Role of Alpha-Synuclein Pathology Open
Alpha-synuclein (αSyn) is a conformationally flexible protein that is known to be involved in key neuronal biological processes and the pathogenesis of Parkinson’s disease (PD). The aggregation of αSyn in the brain is not only the neuropat…
View article: CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism Open
Mutations in the mitochondrial cristae protein CHCHD2 lead to a late-onset autosomal dominant form of Parkinson’s disease (PD) which closely resembles idiopathic PD, providing the opportunity to gain new insights into the mechanisms of mit…
View article: Image Capture and Neuropathological Quantification of post-mortem human brain tissue v1
Image Capture and Neuropathological Quantification of post-mortem human brain tissue v1 Open
This protocol details the fluorescent image analysis pipeline using QuPath to analyse pathological inclusions within human post-mortem brain tissue.
View article: Quantification of pathological protein accumulation (aSyn and tau) in transplanted human iPSC-derived dopamine neurons v1
Quantification of pathological protein accumulation (aSyn and tau) in transplanted human iPSC-derived dopamine neurons v1 Open
This protocol details the immunohistochemistry protocol and subsequent imaging analysis protocols for quantifying pathological protein accumulation in human derived iPSC dopaminergic neurons transplanted into athymic mice. Tissue sections …
View article: Immunofluorescence protocol for FFPE human post-mortem brain sections to detect alpha-synuclein and tau pathology v1
Immunofluorescence protocol for FFPE human post-mortem brain sections to detect alpha-synuclein and tau pathology v1 Open
This protocol details the method for preparing and staining human formalin-fixed, paraffin embedded post mortem brain tissue to detect alpha-synuclein and tau pathology using immunofluorescence.
View article: Immunofluorescence protocol for FFPE human post-mortem brain sections to detect alpha-synuclein and tau pathology v2
Immunofluorescence protocol for FFPE human post-mortem brain sections to detect alpha-synuclein and tau pathology v2 Open
This protocol details the method for preparing and staining human formalin-fixed, paraffin embedded post mortem brain tissue to detect alpha-synuclein and tau pathology using immunofluorescence.
View article: Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions Open
View article: Author response: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Author response: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration Open
Parkinson's disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is likely altered i…
View article: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration Open
Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is likely altered i…
View article: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration Open
Parkinson’s disease (PD) is characterized by the death of substantia nigra pars compacta (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is li…
View article: MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity
MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity Open
Lewy pathology, consisting of Lewy bodies and Lewy neurites, is the pathological hallmark of synucle-inopathies such as Parkinson’s disease and dementia with Lewy bodies, but it is generally thought to represent late-stage pathological cha…
View article: Human Endogenous Retroviruses in Neurodegenerative Diseases
Human Endogenous Retroviruses in Neurodegenerative Diseases Open
Human endogenous retroviruses (HERVs) are DNA transposable elements that have integrated into the human genome via an ancestral germline infection. The potential importance of HERVs is underscored by the fact that they comprise approximate…