Yuqin Song
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View article: Precision Reprogramming in CAR-T Cell Therapy: Innovations, Challenges, and Future Directions of Advanced Gene Editing
Precision Reprogramming in CAR-T Cell Therapy: Innovations, Challenges, and Future Directions of Advanced Gene Editing Open
View article: The effect of parental marital status on non-suicidal self-injurious behavior among middle school students in rural western China: a multicenter cross-sectional study based on propensity score matching method
The effect of parental marital status on non-suicidal self-injurious behavior among middle school students in rural western China: a multicenter cross-sectional study based on propensity score matching method Open
Introduction Parental marital status is a pivotal determinant of adolescent maladaptive behaviors. However, the specific correlation between parental marital status and Non-Suicidal Self-Injury (NSSI) among adolescents in western China has…
View article: Identification of the CDPK Pan-Genomic Family in Pear (Pyrus spp.) and Analysis of Its Response to Venturia nashicola
Identification of the CDPK Pan-Genomic Family in Pear (Pyrus spp.) and Analysis of Its Response to Venturia nashicola Open
This study investigated the phylogenetic relationships in the pear calcium-dependent protein kinase (CDPK) pan-gene family and elucidated its role in the resistance to scab disease caused by Venturia nashicola. By integrating data from eig…
View article: 200 Costs of Emergency Department Observation Care for Ambulatory and Emergency Care Sensitive Conditions
200 Costs of Emergency Department Observation Care for Ambulatory and Emergency Care Sensitive Conditions Open
View article: Phase 2 Study of Relmacabtagene Autoleucel (CD19 CAR-T) for Relapsed/Refractory Mantle Cell Lymphoma in Chinese Adults
Phase 2 Study of Relmacabtagene Autoleucel (CD19 CAR-T) for Relapsed/Refractory Mantle Cell Lymphoma in Chinese Adults Open
Relma-cel, an anti-CD19 CAR-T therapy, is approved in China for R/R large B-cell lymphoma and follicular lymphoma. This phase 2, open-label, single-arm, multicenter study evaluated its efficacy and safety in Chinese patients with heavily p…
View article: Safety and efficacy of HH2853, a novel EZH1/2 dual inhibitor, in patients with refractory solid tumours or non-Hodgkin lymphomas: a phase I study
Safety and efficacy of HH2853, a novel EZH1/2 dual inhibitor, in patients with refractory solid tumours or non-Hodgkin lymphomas: a phase I study Open
View article: Core Symptoms Between Adolescent Psychological Abuse-Neglect and Impulsiveness: A Network Analysis
Core Symptoms Between Adolescent Psychological Abuse-Neglect and Impulsiveness: A Network Analysis Open
Background: Psychological abuse and neglect are considered fundamental to the development of impulsiveness. However, the interplay between psychological abuse-neglect symptoms and impulsiveness dimensions remains unclear, especially during…
View article: RmpA drives metabolic reprogramming to modulate the phenotypic switch between hypermucoviscosity and biofilm formation in hypervirulent Klebsiella pneumoniae
RmpA drives metabolic reprogramming to modulate the phenotypic switch between hypermucoviscosity and biofilm formation in hypervirulent Klebsiella pneumoniae Open
View article: Genetic Subtype‐Based International Prognostic Index Prognostic Model in Diffuse Large B‐Cell Lymphoma
Genetic Subtype‐Based International Prognostic Index Prognostic Model in Diffuse Large B‐Cell Lymphoma Open
Molecular subtyping in diffuse large B‐cell lymphoma (DLBCL) leads to facilitating drug selection. However, an integrated prognostic model based on molecular subtyping and clinical features has not been well established. Here, we retrospec…
View article: The impact of only-child status on adolescent mental health: a multi-center cross-sectional study using propensity score matching in Western China
The impact of only-child status on adolescent mental health: a multi-center cross-sectional study using propensity score matching in Western China Open
This study reveals that the only-child adolescents possibly showing better psychological well-being overall in western China. This study's findings suggest that, during adolescent development, families and society should pay greater attent…
View article: 288 | FIVE‐YEAR ANALYSIS OF AN ASIA SUBPOPULATION WITH PREVIOUSLY UNTREATED DLBCL CONFIRMS POLA‐R‐CHP BENEFIT ON OUTCOMES: THE POLARIX STUDY
288 | FIVE‐YEAR ANALYSIS OF AN ASIA SUBPOPULATION WITH PREVIOUSLY UNTREATED DLBCL CONFIRMS POLA‐R‐CHP BENEFIT ON OUTCOMES: THE POLARIX STUDY Open
View article: OT03 | BGB‐11417‐302, A PHASE 3, RANDOMIZED, DOUBLE‐BLIND STUDY OF SONROTOCLAX (BGB‐11417) + ZANUBRUTINIB VERSUS PLACEBO + ZANUBRUTINIB IN RELAPSED/REFRACTORY MANTLE CELL LYMPHOMA
OT03 | BGB‐11417‐302, A PHASE 3, RANDOMIZED, DOUBLE‐BLIND STUDY OF SONROTOCLAX (BGB‐11417) + ZANUBRUTINIB VERSUS PLACEBO + ZANUBRUTINIB IN RELAPSED/REFRACTORY MANTLE CELL LYMPHOMA Open
View article: 817 | ADVANTIG‐101: A PHASE 1B/2 STUDY OF OCIPERLIMAB (ANTI‐TIGIT) PLUS TISLELIZUMAB (ANTI‐PD‐1) OR RITUXIMAB IN RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA
817 | ADVANTIG‐101: A PHASE 1B/2 STUDY OF OCIPERLIMAB (ANTI‐TIGIT) PLUS TISLELIZUMAB (ANTI‐PD‐1) OR RITUXIMAB IN RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA Open
View article: 605 | REFINING TREATMENT PARADIGMS FOR MANTLE CELL LYMPHOMA: A TAILORED APPROACH
605 | REFINING TREATMENT PARADIGMS FOR MANTLE CELL LYMPHOMA: A TAILORED APPROACH Open
View article: Beyond maximum grade: tolerability of immunotherapies, cellular therapies, and targeted agents in haematological malignancies
Beyond maximum grade: tolerability of immunotherapies, cellular therapies, and targeted agents in haematological malignancies Open
The increasing use of immunotherapeutic approaches, cellular therapies, and targeted agents is rapidly and profoundly changing the treatment paradigms of haematological malignancies. These novel therapies are increasingly incorporated into…
View article: The Influence of Lévy Noise and Independent Jumps on the Dynamics of a Stochastic COVID-19 Model with Immune Response and Intracellular Transmission
The Influence of Lévy Noise and Independent Jumps on the Dynamics of a Stochastic COVID-19 Model with Immune Response and Intracellular Transmission Open
The coronavirus (COVID-19) expanded rapidly and affected almost the whole world since December 2019. COVID-19 has an unusual ability to spread quickly through airborne viruses and substances. Taking into account the disease’s natural progr…
View article: Insertion sequences accelerate genomic convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae via capsular phase variation
Insertion sequences accelerate genomic convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae via capsular phase variation Open
View article: Leveraging collateral sensitivity to counteract the evolution of bacteriophage resistance in bacteria
Leveraging collateral sensitivity to counteract the evolution of bacteriophage resistance in bacteria Open
The escalating antibiotic resistance crisis poses a major global health threat. Bacteriophage therapy offers a promising alternative for combating multidrug‐resistant infections. However, bacterial resistance to phages remains a significan…
View article: Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial
Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial Open
The phase 2, multicohort, ongoing ELM-2 study evaluates odronextamab, a CD20×CD3 bispecific antibody, in patients with relapsed/refractory (R/R) B cell non-Hodgkin lymphoma after ≥2 lines of therapy. Here primary analysis of the diffuse la…
View article: Low levels of CD3 + and CD8 + T cells in peripheral blood can predict poor efficacy of first-line chemotherapy in patients with angioimmunoblastic T cell lymphoma
Low levels of CD3 + and CD8 + T cells in peripheral blood can predict poor efficacy of first-line chemotherapy in patients with angioimmunoblastic T cell lymphoma Open
View article: A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma
A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma Open
View article: Polatuzumab vedotin plus bendamustine and rituximab in relapsed/refractory diffuse large B-cell lymphoma: A phase III bridging study in Chinese patients
Polatuzumab vedotin plus bendamustine and rituximab in relapsed/refractory diffuse large B-cell lymphoma: A phase III bridging study in Chinese patients Open
Background: Patients with transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) have limited treatment options and poor outcomes. Methods: This phase III study (NCT04236141) evaluated the efficacy and safety o…
View article: Comparison of zuberitamab plus CHOP versus rituximab plus CHOP for the treatment of drug-naïve patients diagnosed with CD20-positive diffuse large B-cell lymphoma: a phase 3 trial
Comparison of zuberitamab plus CHOP versus rituximab plus CHOP for the treatment of drug-naïve patients diagnosed with CD20-positive diffuse large B-cell lymphoma: a phase 3 trial Open
Background In patients with untreated CD20-positive diffuse large B-cell lymphoma (DLBCL), a phase 3 trial was carried out to evaluate the efficacy and safety of zuberitamab plus CHOP (cyclophosphamide, doxorubicin, vincristine, and predni…
View article: Prevalence and associated factors of adolescent psychological abuse, neglect in Western China a multi-center cross-sectional study
Prevalence and associated factors of adolescent psychological abuse, neglect in Western China a multi-center cross-sectional study Open
Background: The western region of China has a dense population, relatively underdeveloped economy, and a significant number of left-behind children. Currently, the prevalence of adolescent psychological abuse, neglect, and the facto…
View article: Data‐Driven Engineering of Phages with Tunable Capsule Tropism for <i>Klebsiella pneumoniae</i>
Data‐Driven Engineering of Phages with Tunable Capsule Tropism for <i>Klebsiella pneumoniae</i> Open
Klebsiella pneumoniae , a major clinical pathogen known for causing severe infections, is attracting heightened attention due to its escalating antibiotic resistance. Phages are emerging as a promising alternative to antibiotics; however, …
View article: A Novel Stochastic Model for Human Norovirus Dynamics: Vaccination Impact with Lévy Noise
A Novel Stochastic Model for Human Norovirus Dynamics: Vaccination Impact with Lévy Noise Open
The epidemic norovirus causes vomiting and diarrhea and is a highly contagious infection. The disease is affecting human lives in terms of deaths and medical expenses. This study examines the governing dynamics of norovirus by incorporatin…
View article: PI3K inhibitor idelalisib enhances the anti-tumor effects of CDK4/6 inhibitor palbociclib via PLK1 in B-cell lymphoma
PI3K inhibitor idelalisib enhances the anti-tumor effects of CDK4/6 inhibitor palbociclib via PLK1 in B-cell lymphoma Open
Relapsed or refractory diffuse large B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) patients still faced with poor survival, representing an unmet clinical need. In-depth research into the disease's pathogenesis and the development…
View article: Chinese experience in hematopoietic stem cell mobilization and collection in lymphoma patients: a retrospective cohort study
Chinese experience in hematopoietic stem cell mobilization and collection in lymphoma patients: a retrospective cohort study Open
Lymphoma can be treated with autologous hematopoietic stem cell transplantation. The mobilization and collection of hematopoietic stem cells is essential for the success of stem cell transplantation. From January 2017 to December 2022, 561…
View article: Understanding the rapid spread of antimicrobial resistance genes mediated by IS<i>26</i>
Understanding the rapid spread of antimicrobial resistance genes mediated by IS<i>26</i> Open
Insertion sequences (ISs) promote the transmission of antimicrobial resistance genes (ARGs) across bacterial populations. However, their contributions and dynamics during the transmission of resistance remain unclear. In this study, we sel…
View article: The mediating role of impulsivity between sleep quality and suicidal ideation in adolescent population: a multicenter cross-sectional study in the northeastern Sichuan, China
The mediating role of impulsivity between sleep quality and suicidal ideation in adolescent population: a multicenter cross-sectional study in the northeastern Sichuan, China Open
Introduction Suicidal ideation is a critical early stage in the progression towards suicidal be havior. Prior research has established links between sleep quality, impulsivity, and suicidal tendencies, yet the interaction among these facto…