Yuqing Chen
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View article: Cost-effectiveness analysis of metagenomic next-generation sequencing versus traditional bacterial cultures for postoperative central nervous system infections in critical care settings: a prospective pilot study
Cost-effectiveness analysis of metagenomic next-generation sequencing versus traditional bacterial cultures for postoperative central nervous system infections in critical care settings: a prospective pilot study Open
Background Early and accurate pathogen identification is crucial for managing central nervous system infections (CNSIs). While Metagenomic Next-Generation Sequencing (mNGS) offers rapid and sensitive pathogen detection, its cost-effectiven…
View article: Cyclic-di-GMP interferes with DNA-MucR-DNA bridging to derepress genes targeted by the xenogeneic silencer MucR
Cyclic-di-GMP interferes with DNA-MucR-DNA bridging to derepress genes targeted by the xenogeneic silencer MucR Open
The tradeoff between the benefits and costs of maintaining AT-rich accessory genes is vital in bacterial ecology and evolution. MucR is a conserved xenogeneic silencer for AT-rich accessory genes within α-proteobacteria, but its anti-silen…
View article: Diagnosis and treatment of severe acute sepsis caused by Burkholderia pseudomallei infection: a case report and literature review
Diagnosis and treatment of severe acute sepsis caused by Burkholderia pseudomallei infection: a case report and literature review Open
Melioidosis, caused by Burkholderia pseudomallei , is a tropical infectious disease with diverse clinical manifestations, which can rapidly progress to acute sepsis and multiorgan failure with high mortality. Here, we report a 45-year-old …
View article: Integrated analysis of metabolome and microbiome in a mouse model of sodium valproate-induced autism
Integrated analysis of metabolome and microbiome in a mouse model of sodium valproate-induced autism Open
Sodium valproate (SV) has been shown to induce autism in animal models. In this study, the SV method was used to establish a mouse model of autism, and anxiety-like behaviours and learning memory performance were evaluated by behavioural t…
View article: Current clinical profiles for Chinese hemodialysis patients
Current clinical profiles for Chinese hemodialysis patients Open
View article: Cardiorespiratory fitness-associated gene signature for prognosis in hepatocellular Carcinoma: Computational prediction and in vivo validation
Cardiorespiratory fitness-associated gene signature for prognosis in hepatocellular Carcinoma: Computational prediction and in vivo validation Open
Cardiorespiratory fitness (CRF) plays a crucial role in cancer progression and prognosis, yet its molecular mechanisms remain poorly understood. This study aims to develop a prognostic model based on CRF-related genes in hepatocellular car…
View article: Unraveling the Complex Cellular Repair Mechanisms Following Myocardial Infarction
Unraveling the Complex Cellular Repair Mechanisms Following Myocardial Infarction Open
Growing evidence underscores the pivotal roles of both in situ-resident and -non-resident cardiac cells in the repair mechanisms following myocardial infarction (MI). MI continues to be a predominant cause of death and disability, posing a…
View article: Corrigendum to “Yield of clinical metagenomics: insights from real-world practice for tissue infections” [eBioMedicine 111(2025), 105536]
Corrigendum to “Yield of clinical metagenomics: insights from real-world practice for tissue infections” [eBioMedicine 111(2025), 105536] Open
View article: Aroma Release and Consumer Perception During Cider Consumption
Aroma Release and Consumer Perception During Cider Consumption Open
Flavor is an important property affecting consumer acceptance, yet little is known about the correlation between the sensory attributes, volatile compounds, and consumer preference during cider consumption. This study was the first to eval…
View article: Research focus and theme trend on Charcot–Marie–Tooth disease since 2000: a bibliometric analysis
Research focus and theme trend on Charcot–Marie–Tooth disease since 2000: a bibliometric analysis Open
Background Charcot–Marie–Tooth disease (CMT) represents a hereditary neuromuscular disorder characterized by an incomplete pathological understanding and a lack of effective therapeutic interventions. This study aimed to investigate the ad…
View article: Bioinformatics approach reveals the critical role of inflammation-related genes in age-related hearing loss
Bioinformatics approach reveals the critical role of inflammation-related genes in age-related hearing loss Open
Age-related hearing loss (ARHL) is the most prevalent sensory impairment in the elderly. However, the pathogenesis of ARHL remains unclear. This study was aimed to explore the potential inflammation-related genes of ARHL and suggest novel …
View article: Early versus late nephrology referral and patient outcomes in chronic kidney disease: an updated systematic review and meta-analysis
Early versus late nephrology referral and patient outcomes in chronic kidney disease: an updated systematic review and meta-analysis Open
View article: Genomic Analysis of 2151 Chinese Patients with Suspected Genetic Kidney Disease
Genomic Analysis of 2151 Chinese Patients with Suspected Genetic Kidney Disease Open
View article: Geology-Guided Quantification of Mechanical Specific Energy for Optimizated Completion Design
Geology-Guided Quantification of Mechanical Specific Energy for Optimizated Completion Design Open
View article: Yield of clinical metagenomics: insights from real-world practice for tissue infections
Yield of clinical metagenomics: insights from real-world practice for tissue infections Open
National Natural Science Foundation of China (No. 82472371), "Leading Geese" Research and Development Plan of Zhejiang Province (No. 2024C03218), and Pudong New Area Joint Project (PW2021D-09).
View article: Evaluation of gecacitinib vs hydroxyurea in patients with intermediate-2 or high-risk myelofibrosis: final analysis results from a randomized phase 3 study
Evaluation of gecacitinib vs hydroxyurea in patients with intermediate-2 or high-risk myelofibrosis: final analysis results from a randomized phase 3 study Open
To compare the efficacy and safety of gecacitinib (also known as jaktinib) with hydroxyurea (HU) in treating myelofibrosis (MF) patients. In this multicenter, randomized phase 3 trial (ZGJAK016), intermediate- or high-risk primarily JAK in…
View article: Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study
Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study Open
Objective The relationship between tinnitus in the elderly with hearing loss remains elusive. This study aimed to reveal the association between tinnitus and hearing impairment among older adults with age-related hearing loss (ARHL). Metho…
View article: Platelet count has a U-shaped association with mortality in hemodialysis patients
Platelet count has a U-shaped association with mortality in hemodialysis patients Open
View article: Bioinformatical analysis and experimental validation of endoplasmic reticulum stress-related biomarker genes in type 2 diabetes mellitus
Bioinformatical analysis and experimental validation of endoplasmic reticulum stress-related biomarker genes in type 2 diabetes mellitus Open
Introduction Endoplasmic reticulum stress (ERS) is a prominent etiological factor in the pathogenesis of diabetes. Nevertheless, the mechanisms through which ERS contributes to the development of diabetes remain elusive. Methods Transcript…
View article: Explaining International Trends in Mortality on Hemodialysis Through Changes in Hemodialysis Practices in the Dialysis Outcomes and Practice Patterns Study (DOPPS)
Explaining International Trends in Mortality on Hemodialysis Through Changes in Hemodialysis Practices in the Dialysis Outcomes and Practice Patterns Study (DOPPS) Open
View article: Autosomal Dominant Tubulointerstitial Kidney Disease–UMOD: A Monogenic Renal Disease that Cannot Be Ignored
Autosomal Dominant Tubulointerstitial Kidney Disease–UMOD: A Monogenic Renal Disease that Cannot Be Ignored Open
Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a group of monogenic renal diseases characterized by autosomal dominant inheritance and progressive tubulointerstitial damage with bland urinary sediment. With the discovery o…
View article: Assessment of right ventricular dysfunction and its association with excess risk of cardiovascular events in patients undergoing maintenance hemodialysis
Assessment of right ventricular dysfunction and its association with excess risk of cardiovascular events in patients undergoing maintenance hemodialysis Open
RVD, assessed by echocardiography TAPSE/PASP ratio, was found to be associated with increased risks of CVD events and frequent IDH in patients with MHD.
View article: The influencing factors of the erythropoietin resistance index and its association with all-cause mortality in maintenance hemodialysis patients
The influencing factors of the erythropoietin resistance index and its association with all-cause mortality in maintenance hemodialysis patients Open
Anemia is a common complication of chronic kidney disease with major option treatment of erythropoiesis-stimulating agents (ESAs). This study aimed to investigate the influencing factors of erythropoietin resistance index (ERI) and its ass…
View article: Identification and experimental validation of ferroptosis-related gene lactotransferrin in age-related hearing loss
Identification and experimental validation of ferroptosis-related gene lactotransferrin in age-related hearing loss Open
Objective To reveal the relationship between ARHL and ferroptosis and screen ferroptosis-related genes (FRGs) in ARHL. Methods Bioinformatics were used to analyze the hub genes and molecular mechanism of ferroptosis in the aging cochleae. …
View article: The association between high jugular bulb and mastoid pneumatization in adults
The association between high jugular bulb and mastoid pneumatization in adults Open
Purpose The purpose of this study was to analyze the relationship between the degree of high jugular bulb (HJB) and mastoid pneumatization using high-resolution computed tomography (HRCT). Methods Between April 2019 and June 2022, HRCT of …
View article: Mortality of Peritoneal Dialysis versus Hemodialysis in Older Adults: An Updated Systematic Review and Meta-Analysis
Mortality of Peritoneal Dialysis versus Hemodialysis in Older Adults: An Updated Systematic Review and Meta-Analysis Open
Introduction: The optimal choice of dialysis modality remains contentious in older adults threatened by advanced age and high risk of comorbidities. Methods: We conducted a systematic review and meta-analysis of…
View article: Preparation of Heteroatom-Doped Hyper-Crosslinked Polymers Via Waste Utilization of Sulfur-Containing Petroleum Coke: A Promising Adsorbent for Co 2 Capture
Preparation of Heteroatom-Doped Hyper-Crosslinked Polymers Via Waste Utilization of Sulfur-Containing Petroleum Coke: A Promising Adsorbent for Co 2 Capture Open
View article: RATE OF CHANGE IN DEPRESSIVE SYMPTOMS OVER THE FINAL MENSTRUAL PERIOD
RATE OF CHANGE IN DEPRESSIVE SYMPTOMS OVER THE FINAL MENSTRUAL PERIOD Open
Studies have shown that women are more vulnerable to elevated depressive symptoms during the menopause transition (MT) then before. This study evaluates change in depressive symptoms, as measured by the Center for Epidemiological Studies-D…
View article: Body Mass Index (BMI) and BMI Variability are Risk Factors for Heart Failure with Preserved and Reduced Ejection Fraction in a Longitudinal Cohort Study Using Real-World Electronic Health Records
Body Mass Index (BMI) and BMI Variability are Risk Factors for Heart Failure with Preserved and Reduced Ejection Fraction in a Longitudinal Cohort Study Using Real-World Electronic Health Records Open
Objective The aim of this study is to evaluate the differential impact of BMI and long-term intra-individual BMI variability on the risk of developing heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ej…
View article: A patient with tumor necrosis factor receptor-associated periodic syndrome misdiagnosed as Kawasaki disease: A case report and literature review
A patient with tumor necrosis factor receptor-associated periodic syndrome misdiagnosed as Kawasaki disease: A case report and literature review Open
This article reports a case of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) misdiagnosed as Kawasaki disease and summarizes the clinical features and therapeutic progress of TRAPS and the relationship between its cli…