Yuqing Long
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View article: Harnessing a Surface Water-Based Multifaceted Approach to Combat Zoonotic Viruses: A Rural Perspective from Bangladesh and China
Harnessing a Surface Water-Based Multifaceted Approach to Combat Zoonotic Viruses: A Rural Perspective from Bangladesh and China Open
Rural tropical regions face escalating threats from zoonotic AIV and dengue virus but lack sewered infrastructure for conventional wastewater surveillance. We implemented surface water-based surveillance (SWBS) in peri-urban Dhaka (Banglad…
View article: Protective early innate immune activation by mitochondrial antiviral signalling protein (MAVS) in bacterial pneumonia
Protective early innate immune activation by mitochondrial antiviral signalling protein (MAVS) in bacterial pneumonia Open
Mitochondrial antiviral signalling protein (MAVS) is important for host antiviral immunity and recent studies suggest its role in fungal defence. However, the role of MAVS in antibacterial host defence remains unclear. The Gram-negative ba…
View article: Extracellular Membrane Vesicles of Escherichia coli Induce Apoptosis of CT26 Colon Carcinoma Cells
Extracellular Membrane Vesicles of Escherichia coli Induce Apoptosis of CT26 Colon Carcinoma Cells Open
Escherichia coli (E. coli) is commonly utilized as a vehicle for anti-tumor therapy due to its unique tumor-targeting capabilities and ease of engineering modification. To further explore the role of E. coli in tumor treatment, we consider…
View article: G-cleave LC3B Biosensor: Monitoring Autophagy and Assessing Resveratrol's Synergistic Impact on Doxorubicin-Induced Apoptosis in Breast Cancer Cells
G-cleave LC3B Biosensor: Monitoring Autophagy and Assessing Resveratrol's Synergistic Impact on Doxorubicin-Induced Apoptosis in Breast Cancer Cells Open
Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, l…
View article: Unveiling IL6R and MYC as Targeting Biomarkers in Imatinib-Resistant Chronic Myeloid Leukemia through Advanced Non-Invasive Apoptosis Detection Sensor Version 2 Detection
Unveiling IL6R and MYC as Targeting Biomarkers in Imatinib-Resistant Chronic Myeloid Leukemia through Advanced Non-Invasive Apoptosis Detection Sensor Version 2 Detection Open
The management of chronic myelogenous leukemia (CML) has seen significant progress with the introduction of tyrosine kinase inhibitors (TKIs), particularly Imatinib. However, a notable proportion of CML patients develop resistance to Imati…
View article: MAIT Cells in Respiratory Viral Infections in Mouse and Human
MAIT Cells in Respiratory Viral Infections in Mouse and Human Open
Mucosal associated invariant T (MAIT) cells were first identified as specific for bacterial, mycobacterial, and fungal organisms, which detect microbially-derived biosynthetic ligands presented by MHC-related protein 1 (MR1). More recently…
View article: Fis Contributes to Resistance of Pseudomonas aeruginosa to Ciprofloxacin by Regulating Pyocin Synthesis
Fis Contributes to Resistance of Pseudomonas aeruginosa to Ciprofloxacin by Regulating Pyocin Synthesis Open
Pseudomonas aeruginosa is an important opportunistic pathogenic bacterium that causes various acute and chronic infections in human, especially in patients with compromised immunity, cystic fibrosis (CF), and/or severe burn wounds. About 6…
View article: TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in Pseudomonas aeruginosa
TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in Pseudomonas aeruginosa Open
The increase in bacterial resistance against antibiotics imposes a severe threat to public health. It is urgent to identify new drug targets and develop novel antimicrobials. Metabolic homeostasis of bacteria plays an essential role in the…
View article: HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa
HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa Open
Toxin-antitoxin (TA) systems play important roles in bacteria persister formation. Increasing evidence demonstrate the roles of TA systems in regulating virulence factors in pathogenic bacteria. The toxin HigB in Pseudomonas aeruginosa con…
View article: Development and evaluation of novel recombinant adenovirus-based vaccine candidates for infectious bronchitis virus and <i>Mycoplasma gallisepticum</i> in chickens
Development and evaluation of novel recombinant adenovirus-based vaccine candidates for infectious bronchitis virus and <i>Mycoplasma gallisepticum</i> in chickens Open
Avian infectious bronchitis caused by the infectious bronchitis virus (IBV), and mycoplasmosis caused by Mycoplasma gallisepticum (MG) are two major respiratory diseases in chickens that have resulted in severe economic losses in the poult…
View article: HigB of Pseudomonas aeruginosa Enhances Killing of Phagocytes by Up-Regulating the Type III Secretion System in Ciprofloxacin Induced Persister Cells
HigB of Pseudomonas aeruginosa Enhances Killing of Phagocytes by Up-Regulating the Type III Secretion System in Ciprofloxacin Induced Persister Cells Open
Bacterial persister cells are dormant and highly tolerant to lethal antibiotics, which are believed to be the major cause of recurring and chronic infections. Activation of toxins of bacterial toxin-antitoxin systems inhibits bacterial gro…