Yuqing Tuo
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View article: CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway
CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway Open
CCR2, a member of the G protein-coupled receptor (GPCR) superfamily, is widely expressed on monocytes, macrophages, activated T cells, and other cell types, and plays a critical role in coordinating the immune response to various infection…
View article: Il-27 / Il-27r Regulates the Balance of M1 / M2 to Alleviate the Inflammation Response During Chlamydia Muridarum Respiratory Infection
Il-27 / Il-27r Regulates the Balance of M1 / M2 to Alleviate the Inflammation Response During Chlamydia Muridarum Respiratory Infection Open
View article: Insights into Chlamydia Development and Host Cells Response
Insights into Chlamydia Development and Host Cells Response Open
Chlamydia infections commonly afflict both humans and animals, resulting in significant morbidity and imposing a substantial socioeconomic burden worldwide. As an obligate intracellular pathogen, Chlamydia interacts with other cell organel…
View article: In Silico Identification and Validation of Pyroptosis-Related Genes in Chlamydia Respiratory Infection
In Silico Identification and Validation of Pyroptosis-Related Genes in Chlamydia Respiratory Infection Open
The incidence of Chlamydia trachomatis respiratory infection is increasing, and its pathogenesis is still unclear. Pyroptosis, as a mode of inflammatory cell death, plays a vital role in the occurrence and development of Chlamydia trachoma…
View article: IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection
IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection Open
Interleukin-21 and its receptors (IL-21/IL-21R) aggravate chlamydial lung infection, while macrophages (Mφ) are one of the main cells infected by chlamydia and the main source of inflammatory cytokines. Therefore, it is particularly import…
View article: IL-27 Signaling Promotes Th1 Response by Downregulating IL-10 Production in DCs during Chlamydial Respiratory Infection
IL-27 Signaling Promotes Th1 Response by Downregulating IL-10 Production in DCs during Chlamydial Respiratory Infection Open
Chlamydia trachomatis usually causes mucosal infections, bringing considerable morbidity and socioeconomic burden worldwide. We previously revealed that IL-27/IL-27R mediates protection against chlamydial invasion by promoting a protective…
View article: A Pathogenic Role for FcγRI in the Immune Response against Chlamydial Respiratory Infection
A Pathogenic Role for FcγRI in the Immune Response against Chlamydial Respiratory Infection Open
FcγRI is an important cell surface receptor reported to be involved in multiple immune responses, although it has not yet been extensively studied in intracellular bacterial infections. Here, using a mouse model of C. muridarum respiratory…
View article: IL-21/IL-21R Regulates the Neutrophil-Mediated Pathologic Immune Response during Chlamydial Respiratory Infection
IL-21/IL-21R Regulates the Neutrophil-Mediated Pathologic Immune Response during Chlamydial Respiratory Infection Open
IL-21/IL-21R was documented to participate in the regulation of multiple infection and inflammation. During Chlamydia muridarum (C. muridarum) respiratory infection, our previous study had revealed that the absence of this signal induced e…