Yuqiu Zhou
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View article: Social participation, loneliness and cognitive function in the elderly in China: a cross- lagging longitudinal study based on CLHLS
Social participation, loneliness and cognitive function in the elderly in China: a cross- lagging longitudinal study based on CLHLS Open
Background With the acceleration of the aging process of the Chinese population, Cognitive dysfunction in the elderly has emerged as a significant challenge for healthy aging. The dynamic relationship and causal pathways between social par…
View article: Development and validation of the help-seeking motivation scale for patients with schizophrenia(HSMS)
Development and validation of the help-seeking motivation scale for patients with schizophrenia(HSMS) Open
View article: Development and validation of the Help-Seeking Motivation Scale for patients with schizophrenia (HSMS）
Development and validation of the Help-Seeking Motivation Scale for patients with schizophrenia (HSMS） Open
Objective Schizophrenia is one of the mental disorders with the longest delay in treatment. Motivation for help-seeking is an important factor in getting professional treatment. There is no instrument to measure help-seeking motivation in …
View article: Esophageal cancer burden attributable to alcohol use and low consumption of vegetables from 1990 to 2021 across countries with different sociodemographic characteristics
Esophageal cancer burden attributable to alcohol use and low consumption of vegetables from 1990 to 2021 across countries with different sociodemographic characteristics Open
Background: Esophageal cancer (EC) is a lethal malignancy. The sociodemographic index (SDI) is a critical factor influencing the disease burden of EC. Risk factors, including alcohol use and diet, vary significantly by SDI level, affecting…
View article: Family Resilience in Patients With Schizophrenia: Potential Influencing Factors and Mediating Effect
Family Resilience in Patients With Schizophrenia: Potential Influencing Factors and Mediating Effect Open
Objective To identify the determinants of family resilience in the recovery of individuals with schizophrenia using Walsh's family resilience framework. Design A cross‐sectional study. Methods In Northeast China, 403 patients diagnosed wit…
View article: “Aging Amplifies Challenges”: A Descriptive Phenomenological Exploration of the Lived Experiences and Needs of Elderly Individuals With Schizophrenia
“Aging Amplifies Challenges”: A Descriptive Phenomenological Exploration of the Lived Experiences and Needs of Elderly Individuals With Schizophrenia Open
Older adults diagnosed with schizophrenia face unique public health challenges, with specific treatment needs, complex care demands, accelerated aging, and increased susceptibility to health issues. This phenomenological study explored the…
View article: Hb H disease caused by uniparental disomy: first report of the αT-Saudiα mutation in the Chinese population
Hb H disease caused by uniparental disomy: first report of the αT-Saudiα mutation in the Chinese population Open
View article: Oral frailty: a concept analysis
Oral frailty: a concept analysis Open
View article: Application of various genetic analysis techniques for detecting two rare cases of 9p duplication mosaicism during prenatal diagnosis
Application of various genetic analysis techniques for detecting two rare cases of 9p duplication mosaicism during prenatal diagnosis Open
Background The identification of genetic mosaicism and the genetic counseling needed following its discovery have been challenging problems in the field of prenatal diagnosis. Herein, we describe the clinical phenotypes and various prenata…
View article: MALDI–TOF–MS for Rapid Screening and Typing of β-Globin Variant and β-Thalassemia through Direct Measurements of Intact Globin Chains
MALDI–TOF–MS for Rapid Screening and Typing of β-Globin Variant and β-Thalassemia through Direct Measurements of Intact Globin Chains Open
Background Traditional phenotype-based screening for β-globin variant and β-thalassemia using hematological parameters is time-consuming with low-resolution detection. Development of a MALDI–TOF–MS assay using alternative markers is needed…
View article: Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus
Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus Open
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease which can affect various tissues and organs, posing significant challenges for clinical diagnosis and treatment. The etiology of SLE is highly complex with contribut…
View article: Prenatal diagnosis of a 4.5-Mb deletion at chromosome 4q35.1q35.2: Case report and literature review
Prenatal diagnosis of a 4.5-Mb deletion at chromosome 4q35.1q35.2: Case report and literature review Open
Objective We present a genetic analysis of an asymptomatic family with a 4q terminal deletion; we also review other similar published studies and discuss the genotype–phenotype correlation. Methods A karyotype analysis was performed on the…
View article: Epidemiological and clinical characteristics of respiratory viruses in 4403 pediatric patients from multiple hospitals in Guangdong, China
Epidemiological and clinical characteristics of respiratory viruses in 4403 pediatric patients from multiple hospitals in Guangdong, China Open
View article: NGS-based spinal muscular atrophy carrier screening of 10,585 diverse couples in China: a pan-ethnic study
NGS-based spinal muscular atrophy carrier screening of 10,585 diverse couples in China: a pan-ethnic study Open
View article: Rare Double Heterozygosity for Poly A(A>G) and CD17(A>T) of Beta Thalassemia Intermedia in a Chinese Family
Rare Double Heterozygosity for Poly A(A>G) and CD17(A>T) of Beta Thalassemia Intermedia in a Chinese Family Open
Beta thalassemia is a hereditary disorder resulted from mutations in the β globin gene leading to alpha/beta imbalance, ineffective erythropoiesis, and chronic anemia. Three types have been defined, based on the degree of reduced beta-glob…
View article: LOVD–DASH: A comprehensive LOVD database coupled with diagnosis and an at‐risk assessment system for hemoglobinopathies
LOVD–DASH: A comprehensive LOVD database coupled with diagnosis and an at‐risk assessment system for hemoglobinopathies Open
Hemoglobinopathies are the most common monogenic disorders worldwide. Substantial effort has been made to establish databases to record complete mutation spectra causing or modifying this group of diseases. We present a variant database wh…
View article: Pilot study of expanded carrier screening for 11 recessive diseases in China: results from 10,476 ethnically diverse couples
Pilot study of expanded carrier screening for 11 recessive diseases in China: results from 10,476 ethnically diverse couples Open
Expanded carrier screening (ECS) has been demonstrated to increase the detection rate of carriers compared with traditional tests. The aim of this study was to assess the potential value of ECS for clinical application in Southern China, a…
View article: Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies
Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies Open
View article: Human STEAP3 mutations with no phenotypic red cell changes
Human STEAP3 mutations with no phenotypic red cell changes Open
a phase 2 clinical trial with a combination of the SYK inhibitor GS9973 and idelalisib, 13.6% of CLL and/or non-Hodgkin lymphoma patients developed severe pneumonitis leading to early termination of the study. 15 The underlying pathophysio…