Yuriy I. Sysoev
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View article: PHARMACO-EEG-BASED CLASSIFICATION OF PSYCHOTROPIC ACTIVITY OF A NOVEL CHROMONE-CONTAINING ALLYLMORPHOLINE IN RATS
PHARMACO-EEG-BASED CLASSIFICATION OF PSYCHOTROPIC ACTIVITY OF A NOVEL CHROMONE-CONTAINING ALLYLMORPHOLINE IN RATS Open
Purpose: Chromone-containing allylmorpholines (CCAMs) are a promising group for which a dose-dependent inhibition of locomotion in Danio rerio has been shown. Experiments using behavioural tests on mice did not allow to determine the speci…
View article: Animal Models of Spinal Cord Injury
Animal Models of Spinal Cord Injury Open
Spinal cord injury (SCI) is one of the most frequent causes of disability, accompanied by motor and postural impairments, as well as autonomic and behavioural disorders. Since the beginning of the last century, researchers have been develo…
View article: Evaluation of psychotropic effects of a novel chromone-containing allylmorpholine derivative in BALB/c mice
Evaluation of psychotropic effects of a novel chromone-containing allylmorpholine derivative in BALB/c mice Open
Introduction. The search for effective approaches to the treatment of anxiety disorders, in particular, the development and study of drugs with anxiolytic action, is currently one of the most urgent tasks of neurobiological research. The s…
View article: Use of an electrical stimulation-induced fatigue protocol to evaluate the myotropic effects of metabolic-active agents in db/db mice
Use of an electrical stimulation-induced fatigue protocol to evaluate the myotropic effects of metabolic-active agents in db/db mice Open
Introduction. Type 2 diabetes mellitus (T2DM) is a chronic condition characterized by insulin resistance, impaired glucose tolerance, and hyperglycaemia. T2DM is a proven risk factor for peripheral neuropathies as well as muscle contractil…
View article: Prospects of Electrocorticography in Neuropharmacological Studies in Small Laboratory Animals
Prospects of Electrocorticography in Neuropharmacological Studies in Small Laboratory Animals Open
Electrophysiological methods of research are widely used in neurobiology. To assess the bioelectrical activity of the brain in small laboratory animals, electrocorticography (ECoG) is most often used, which allows the recording of signals …
View article: Functional mapping of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model
Functional mapping of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model Open
Several neurologic diseases including spinal cord injury, Parkinson’s disease or multiple sclerosis are accompanied by disturbances of the lower urinary tract functions. Clinical data indicates that chronic spinal cord stimulation can impr…
View article: Changes in Brain Electrical Activity after Transient Middle Cerebral Artery Occlusion in Rats
Changes in Brain Electrical Activity after Transient Middle Cerebral Artery Occlusion in Rats Open
Objectives. Ischemic stroke is a leading cause of death and disability worldwide. To search for new therapeutic and pharmacotherapeutic strategies, numerous models of this disease have been proposed, the most popular being transient middle…
View article: Effects of Alpha-2 Adrenergic Agonist Mafedine on Brain Electrical Activity in Rats after Traumatic Brain Injury
Effects of Alpha-2 Adrenergic Agonist Mafedine on Brain Electrical Activity in Rats after Traumatic Brain Injury Open
The search for and development of new neuroprotective (or cerebroprotective) drugs, as well as suitable methods for their preclinical efficacy evaluation, are priorities for current biomedical research. Alpha-2 adrenergic agonists, such as…
View article: Site-Specific Neuromodulation of Detrusor and External Urethral Sphincter by Epidural Spinal Cord Stimulation
Site-Specific Neuromodulation of Detrusor and External Urethral Sphincter by Epidural Spinal Cord Stimulation Open
Impairments of the lower urinary tract function including urine storage and voiding are widely spread among patients with spinal cord injuries. The management of such patients includes bladder catheterization, surgical and pharmacological …
View article: Morpholine derivatives as potential agents for neurological manifestations of nervous system diseases
Morpholine derivatives as potential agents for neurological manifestations of nervous system diseases Open
Diseases of the nervous system, especially those of vascular, traumatic, and neurodegenerative nature, are characterized by high prevalence, disability and mortality rates, and therefore have a particularly big medical and social impact. C…
View article: Rabbit models of ischemic stroke in biomedical research
Rabbit models of ischemic stroke in biomedical research Open
The development of experimental models of ischemic stroke allowing for effective translation of results from animal studies to humans is an important task of modern neuropharmacology. Due to the fact that new drugs with neuroprotective pro…
View article: <p>Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma</p>
Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma Open
Objectives: To prove that our novel ethanolamine derivative (FDES) can normalize overall movement and exploratory activity of rats with traumatic brain injury (TBI) owing to its peculiar properties. Materials and methods: TBI was modeled u…