Yuru Shi
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View article: Association between gut microbiota in HIV-infected patients and immune reconstitution following antiretroviral therapy (ART)
Association between gut microbiota in HIV-infected patients and immune reconstitution following antiretroviral therapy (ART) Open
The ecological imbalance of Morganella might be associated with incomplete immune reconstitution following ART, potentially mediated by GT25 secretions. Consequently, Morganella could serve as a promising biomarker for predicting incomplet…
View article: Clinical characteristics of single human rhinovirus infection and co-infection in the respiratory tract of children
Clinical characteristics of single human rhinovirus infection and co-infection in the respiratory tract of children Open
The study identified HRV as a significant pathogen in childhood respiratory infections, often co-infecting with ADV and RSV, and associated with distinct clinical manifestations such as fever and respiratory complications.
View article: Metagenomic next-generation sequencing for etiological diagnosis of an unexpected rabies case with unclear exposure history
Metagenomic next-generation sequencing for etiological diagnosis of an unexpected rabies case with unclear exposure history Open
The identification of unique RABV sequence through mNGS in the patient's saliva sample suggested that mNGS could serve as a valuable screening tool for the etiological diagnosis of rabies, especially when timely laboratory testing was unav…
View article: Predictive value of serum HBV RNA on HBeAg seroconversion in treated chronic hepatitis B patients
Predictive value of serum HBV RNA on HBeAg seroconversion in treated chronic hepatitis B patients Open
Purpose To investigate the predictive value of serum hepatitis B virus (HBV) RNA on HBeAg seroconversion in treated chronic hepatitis B (CHB) patients. Methods Sixty-four HBeAg-positive CHB patients were selected. They were divided into HB…
View article: Metagenomic next-generation sequencing for etiological diagnosis of an unexpected rabies case with unclear exposure history
Metagenomic next-generation sequencing for etiological diagnosis of an unexpected rabies case with unclear exposure history Open
Background Rabies is an acute and lethal zoonotic disease caused by the rabies virus (RABV). After onset, there are no effective drugs or treatment methods. We reported a fatal rabies case with no clear history of animal bites and atypical…
View article: Novel Biomarker Panel of Let-7d-5p and MiR-140-5p Can Distinguish Latent Tuberculosis Infection from Active Tuberculosis Patients
Novel Biomarker Panel of Let-7d-5p and MiR-140-5p Can Distinguish Latent Tuberculosis Infection from Active Tuberculosis Patients Open
The findings indicated that the logistic regression model built by let-7d-5p and miR-140-5p has the ability to distinguish LTBI from active TB patients.
View article: Clinical Diagnostic Value of Serum 25-Hydroxyvitamin D in Severe Fever with Thrombocytopenia Syndrome
Clinical Diagnostic Value of Serum 25-Hydroxyvitamin D in Severe Fever with Thrombocytopenia Syndrome Open
Patients with SFTS have reduced 25 (OH) D level, and 25 (OH) D is a risk factor for disease severity in patients with SFTS. Vitamin D supplementation may be an effective measure to reduce the risk of infection and improve the prognosis.
View article: Analysis of Metagenomic Next-Generation Sequencing Results of 25 Pus Samples
Analysis of Metagenomic Next-Generation Sequencing Results of 25 Pus Samples Open
Yuru Shi, Jing Wu, Ting Liu, Li Yue, Yang Liu, Yan Gu, Yingjie Qi Department of Clinical Laboratory, Infection Hospital Area of the First Affiliated Hospital of University of Science and Technology of China (Hefei Infectious Disease Hospit…
View article: Understanding etiology of community-acquired central nervous system infections using metagenomic next-generation sequencing
Understanding etiology of community-acquired central nervous system infections using metagenomic next-generation sequencing Open
Background Community-acquired central nervous system infections (CA-CNS infections) have the characteristics of acute onset and rapid progression, and are associated with high levels of morbidity and mortality worldwide. However, there hav…
View article: Detection of <i>Bartonella vinsonii</i> subsp. <i>berkhoffii</i> in an HIV patient using metagenomic Next-Generation Sequencing
Detection of <i>Bartonella vinsonii</i> subsp. <i>berkhoffii</i> in an HIV patient using metagenomic Next-Generation Sequencing Open
Bartonella species are fastidious, aerobic bacteria that are transmitted by blood-sucking arthropods. Bartonella spp. are responsible for cat scratch disease, Carrion's disease, bacillary angiomatosis and trench fever. On the other hand, B…
View article: Optimized Laboratory Detection Strategy for COVID-19 Patients Reduces the Rate of Missed Diagnosis
Optimized Laboratory Detection Strategy for COVID-19 Patients Reduces the Rate of Missed Diagnosis Open
Background: Novel coronavirus pneumonia (NCP) is an emerging, highly contagious community acquired pneumonia (CAP) caused by severe acute SARS-CoV-2. Nucleic acid test currently played a crucial role in diagnosis of suspected COVID-19 pati…
View article: Optimization of Microbiological Laboratory Detection Strategy for Patients in A Designated Hospital Treating Novel Coronavirus Pneumonia in Anhui Province
Optimization of Microbiological Laboratory Detection Strategy for Patients in A Designated Hospital Treating Novel Coronavirus Pneumonia in Anhui Province Open
Novel coronavirus pneumonia (NCP) is an emerging, highly contagious community acquired pneumonia (CAP) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Highly efficient and accurate microbiological laboratory assay i…
View article: Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity <i>In Vitro</i> and Staphylococcus aureus Fitness in Infection Models
Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity <i>In Vitro</i> and Staphylococcus aureus Fitness in Infection Models Open
Alpha toxin (AT) is a cytolytic pore-forming toxin that plays a key role in Staphylococcus aureus pathogenesis; consequently, extensive research was undertaken to understand the AT mechanism of action and its utility as a target for novel …
View article: Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach
Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach Open
Secreted alpha-toxin and surface-localized clumping factor A (ClfA) are key virulence determinants in Staphylococcus aureus bloodstream infections. We previously demonstrated that prophylaxis with a multimechanistic monoclonal antibody (MA…
View article: Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease
Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease Open
Staphylococcus aureus produces numerous virulence factors, each contributing different mechanisms to bacterial pathogenesis in a spectrum of diseases. Alpha toxin (AT), a cytolytic pore-forming toxin, plays a key role in skin and soft tiss…
View article: MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model
MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model Open
Immunocompromised individuals are at increased risk of Staphylococcus aureus pneumonia. Neutralization of alpha-toxin (AT) with the monoclonal antibody (MAb) MEDI4893* protects normal mice from S. aureus pneumonia; however, the effects of …