Explanipedia

Hearing Intervention, Social Isolation, and Loneliness Open

Nicholas S. Reed, Jinyu Chen, Alison Huang, James Russell Pike, Michelle Arnold , et al. · 2025

Importance Promoting social connection among older adults is a public health priority. Addressing hearing loss may reduce social isolation and loneliness among older adults. Objective To describe the effect of a best-practice hearing inter…

A network analysis of changing pain cooccurrence in older adults findings from the second wave of the COPERNICUS study Open

Agnieszka Kujawska, Joanna Androsiuk, Radosław Perkowski, Sławomir Kujawski, Corey B. Simon , et al. · 2025

Over one-third of patients with chronic pain report pain at multiple anatomical sites. The current study examined the co-localization of pain and its intensity over a 2-year follow-up period. Kendall rank correlation coefficient (denoted a…

Exploring the Practice and Meanings of Tai Chi Among Chinese-Speaking Practitioners in Ottawa, Canada Open

Yurun Cai, Eileen O’Connor · 2025

CHARACTERIZATION OF NOVEL ACCELEROMETER-MEASURED PHYSICAL ACTIVITY METRICS BY COGNITIVE STATUS IN OLDER ADULTS Open

Yurun Cai, Beth E. Snitz, Ann D. Cohen · 2024

Although levels of physical activity (PA) are associated with risk of mild cognitive impairment (MCI) and Alzheimer’s disease (AD), most studies have used self-report PA and/or focused solely on intensities (e.g., MVPA) which may lead to r…

A Hearing Intervention and Health-Related Quality of Life in Older Adults Open

Alison Huang, Emmanuel E. Garcia Morales, Michelle Arnold, Sheila Burgard, David Couper , et al. · 2024

Importance Health-related quality of life is a critical health outcome and a clinically important patient-reported outcome in clinical trials. Hearing loss is associated with poorer health-related quality-of-life in older adults. Objective…

Greater recalled pain and movement-evoked pain are associated with longer 400-meter walk and repeat stair climb time: the Study of Muscle, Mobility and Aging Open

Theresa Mau, Haley N. Barnes, Corey B. Simon, Megan Hetherington‐Rauth, Scott R. Bauer , et al. · 2024

Background Musculoskeletal pain frequently accompanies the development of mobility disability and falls in old age. To better understand this, we aimed to quantify the impact of different pain measures—recalled pain and movement-evoked pai…

Cross-sectional associations between multisensory impairment and brain volumes in older adults: Baltimore Longitudinal Study of Aging Open

Chenxin Tian, Jennifer A. Schrack, Yuri Agrawal, Yang An, Yurun Cai , et al. · 2024

Trends in Use of the Cognitive Assessment and Care Planning Services (CAACPS) Visit: A Primary Palliative Care Tool (RP303) Open

Jennifer B. Seaman, Yurun Cai, Danxu Ren · 2024

MUSCULOSKELETAL PAIN CHARACTERISTICS AND OBJECTIVELY MEASURED PHYSICAL ACTIVITY IN OLDER ADULTS Open

Yurun Cai, Fangyu Liu, Amal A. Wanigatunga, Eleanor M. Simonsick, Luigi Ferrucci , et al. · 2023

Pain is associated with reports of restricted physical activity (PA), yet the associations between multiple musculoskeletal pain characteristics and objectively measured PA quantities and patterns in late life are not well understood. A to…

THE ASSOCIATION OF A NOVEL PHYSICAL ACTIVITY METRIC WITH COGNITION AND RISK OF DEMENTIA Open

Yurun Cai, Junhong Zhou, Qu Tian, Amal A. Wanigatunga, Eleanor M. Simonsick , et al. · 2023

Physical activity (PA) is associated with cognitive function and Alzheimer’s disease and related dementias (ADRD). Although associations between continuously measured PA and ADRD have been assessed, multiscale entropy (MSE), which quantifi…

Sensory impairment and algorithmic classification of early cognitive impairment Open

Yurun Cai, Jennifer A. Schrack, Alden L. Gross, Nicole M. Armstrong, Bonnielin K. Swenor , et al. · 2023

INTRODUCTION Sensory impairment (SI) is linked to cognitive decline, but its association with early cognitive impairment (ECI) is unclear. METHODS Sensory functions (vision, hearing, vestibular function, proprioception, and olfaction) were…

Sensory impairment and beta‐amyloid deposition in the Baltimore longitudinal study of aging Open

Lekha V. Yesantharao, Yurun Cai, Jennifer A. Schrack, Alden L. Gross, Hang Wang , et al. · 2023

Introduction Beta‐amyloid (Aβ) plaque deposition is a biomarker of preclinical Alzheimer's disease (AD). Impairments in sensory function are associated with cognitive decline. We sought to investigate the relationship between PET‐indicated…

The alterations in multiple neurophysiological procedures are associated with frailty phenotype in older adults Open

Xin Jiang, Junhong Zhou, Chengyuan Yu, Wenbo Chen, Baofeng Huang , et al. · 2023

Background Older adults oftentimes suffer from the conditions in multiple physiologic systems, interfering with their daily function and thus contributing to physical frailty. The contributions of such multisystem conditions to physical fr…

Application and validation of an algorithmic classification of early impairment in cognitive performance Open

Yurun Cai, Jennifer A. Schrack, Yuri Agrawal, Nicole M. Armstrong, Amal A. Wanigatunga , et al. · 2023

Objective Due to the long prodromal period for dementia pathology, approaches are needed to detect cases before clinically recognizable symptoms are apparent, by which time it is likely too late to intervene. This study contrasted two theo…

ASSOCIATIONS OF GAIT CHARACTERISTICS AND VARIABILITY WITH WALKING EFFICIENCY IN OLDER ADULTS Open

Fangyu Liu, Yurun Cai, Laura Skow, Amal A. Wanigatunga, Qu Tian , et al. · 2022

Higher energetic cost of walking per unit distance has been linked to many adverse health outcomes in older adults. Aging-related changes in gait characteristics have been postulated to contribute to energetic inefficiency, but previous st…

REVISITING THE TEACHING NURSING HOME: IMPACT ON NURSING STUDENTS’ PERCEPTIONS OF WORKING IN LONG-TERM CARE Open

Howard Degenholtz, Marie Boltz, Donna M. Fick, Nancy Hodgson, Kim Strauch , et al. · 2022

Revisiting the Teaching Nursing Home is a two-year pilot project to address the long-term care workforce shortage by introducing nursing students to geriatric nursing while improving quality of care within nursing homes. The initiative has…

THE PHYSIOLOGIC COMPLEXITY OF BEAT-TO-BEAT BLOOD PRESSURE FLUCTUATION IS ASSOCIATED WITH FRAILTY IN OLDER ADULTS Open

Junhong Zhou, Yurun Cai, Yi Guo, Xin Jiang · 2022

Background Beat-to-beat blood pressure (BP) is an important cardiovascular output and regulated by neurophysiologic elements over multiple temporal scales. The multiscale dynamics of beat-to-beat BP fluctuation has thus been characterized …

CHRONIC PAIN AND CIRCUMSTANCES OF FALLS IN COMMUNITY-LIVING OLDER ADULTS Open

Yurun Cai, Suzanne G. Leveille, Ling Shi, Ping Chen, Tongjian You · 2022

Chronic pain is a risk factor contributing to mobility impairment and falls in older adults. Little is known about the patterns of fall circumstances among older adults with pain. This prospective cohort study described frequencies of fall…

MULTISENSORY IMPAIRMENTS AND BRAIN VOLUMES IN MID-TO-LATE LIFE Open

Amal A. Wanigatunga, Chenxin Tian, Yang An, Yurun Cai, Alden L. Gross , et al. · 2022

Age-related sensory impairment, such as loss in vision or hearing, have been linked to poor brain health. Yet, the relationship between co-occurring sensory impairments and brain volumes remains unclear. We used cross-sectional sensory and…

Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence Open

Amal A. Wanigatunga, Venus Chiu, Yurun Cai, Jacek Urbanek, Christine Mitchell , et al. · 2022

Introduction Low physical activity is a criterion of phenotypic frailty defined as an increased state of vulnerability to adverse health outcomes. Whether disengagement from daily all-purpose physical activity is prospectively associated w…

The effects of vitamin D supplementation on frailty in older adults at risk for falls Open

Yurun Cai, Amal A. Wanigatunga, Christine Mitchell, Jacek Urbanek, Edgar R. Miller , et al. · 2022

The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults Open

Xin Jiang, Yurun Cai, Xiaoyan Wu, Baofeng Huang, Yurong Chen , et al. · 2022

Background The blood pressure (BP) is regulated by multiple neurophysiologic elements over multiple temporal scales. The multiscale dynamics of continuous beat-to-beat BP series, which can be characterized by “BP complexity”, may, thus, ca…

Motor and Sensory Function as Predictors of MCI and Dementia in the Baltimore Longitudinal Study of Aging (BLSA) Open

Jennifer A. Schrack, Amal A. Wanigatunga, Yurun Cai, Hang Wang, Yuri Agrawal , et al. · 2021

Motor and sensory impairments are linked with dementia risk, but whether there is a joint effect of deficits in motor and sensory function is unknown. We analyzed 649 BLSA participants (aged 72±11 years; 55% women; 68% white) who had concu…

Visual Impairment and Objectively Measured Physical Activity in Middle-Aged and Older Adults Open

Yurun Cai, Jennifer A. Schrack, E Jian‐Yu, Amal A. Wanigatunga, Jacek Urbanek , et al. · 2021

Vision loss is associated with restricted physical activity (PA), yet the relationship between multiple domains of vision measures and objectively measured PA, especially activity patterns, in mid-to-late life remains unclear. In 603 BLSA …

Sensory Impairment and Algorithmic Classification of Early Cognitive Impairment in Middle-Aged and Older Adults Open

Yurun Cai, Yuri Agrawal, Jennifer A. Schrack, Alden L. Gross, Nicole M. Armstrong , et al. · 2021

Sensory function has been linked to cognitive impairment and dementia, but the link between multiple sensory impairments and early cognitive impairment (ECI) is unclear. Sensory function (vision, hearing, vestibular, proprioception, and ol…

Sensory Impairment and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging Open

Nicole M. Armstrong, Yurun Cai, Hang Wang, Jennifer A. Schrack, Yuri Agrawal , et al. · 2021

Studies have demonstrated a link between sensory impairment and dementia risk, but little is known about the presence of beta-amyloid plaques in individuals with single and multisensory impairments. Sensory function (combinations of vision…

Accelerometer-Derived Patterns of Physical Activity and Incident Frailty Open

Amal A. Wanigatunga, Yurun Cai, Jacek Urbanek, David L. Roth, Jeremy Walston , et al. · 2021

Low physical activity (PA) is a common phenotype of frailty, but whether disengagement of daily lifestyle PA signals impending frailty remains unexplored. Using STURDY (Study to Understand Fall Reduction and Vitamin D in You) data from 499…

Vitamin D Supplementation on Detailed Fall Characteristics Open

Amal A. Wanigatunga, Jürgen Floege, Amanda L. Blackford, Yurun Cai, Jennifer A. Schrack , et al. · 2020

Evidence suggests Vitamin D supplementation may reduce fall risk in older adults, but effects on fall location and severity are less well described. We used STURDY trial data to examine whether Vitamin D supplementation reduces indoor, out…

Motor and Physical Function Impairments in Middle-Aged and Older Adults in the Baltimore Longitudinal Study of Aging Open

Yurun Cai, Qu Tian, Yuri Agrawal, Eleanor M. Simonsick, Jennifer A. Schrack · 2020

Older adults experience motor function decline early in the disablement process, impacting daily activities and contributing to adverse health outcomes. Few studies have comprehensively examined the interrelationships among motor and funct…

Chronic Musculoskeletal Pain and Foot Reaction Time in Older Adults Open

Yurun Cai, Suzanne G. Leveille, Jeffrey M. Hausdorff, Jonathan F. Bean, Brad Manor , et al. · 2020

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