Yousuf Mohammed
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View article: Vitamin D-loaded lipid nanoparticles: antioxidant properties, preparation, optimization, and in vitro characterization
Vitamin D-loaded lipid nanoparticles: antioxidant properties, preparation, optimization, and in vitro characterization Open
Vitamin D 3 -loaded lipid nanoparticles (Vit D 3 -LNP), integrated into an azulene cream, were developed to enhance the topical delivery and stability of Vitamin D 3 . The LNP was formulated using a lipid mixture and hot homogenization-ult…
View article: Preparing some nanocomposite decorated with pharmaceutical compounds and evaluating their biological effectiveness
Preparing some nanocomposite decorated with pharmaceutical compounds and evaluating their biological effectiveness Open
The study involves the preparation of nanocomposites decorated with pharmaceutical compounds and their evaluation for biological effectiveness. These composites primarily utilize materials such as graphene and reduced graphene oxide (RGO).…
View article: Preparation of Arylidene Sulfacetamide Reduced Graphene Oxide Nanocomposites and Measure some of its Optical Properties
Preparation of Arylidene Sulfacetamide Reduced Graphene Oxide Nanocomposites and Measure some of its Optical Properties Open
Nanocomposites based on Schiff base reactions with reduced graphene oxide were prepared, and their optical and mechanical properties were studied. The preparation methods included synthesizing Schiff bases using sulfacetamide and aromatic …
View article: Solute–Vehicle–Skin Interactions and Their Contribution to Pharmacokinetics of Skin Delivery
Solute–Vehicle–Skin Interactions and Their Contribution to Pharmacokinetics of Skin Delivery Open
Human skin provides an effective route of delivery for selected drugs. Topical penetration of molecules is largely attributed to passive diffusion, and the degree of penetration can be represented by in silico, in vitro, and ex vivo models…
View article: Advances in Characterization of Transdermal and Topical Products using Texture Analyzer Systems
Advances in Characterization of Transdermal and Topical Products using Texture Analyzer Systems Open
The efficacy, safety, and stability of transdermal and topical products (TTPs) are of prime importance to consumer acceptance and compliance. To control the consistent textural quality or overall physical properties of TTPs, texture analys…
View article: Vitamin D-Loaded Lipid Nanoparticles for Potential Treatment of Vitiligo: Preparation, Optimization, and In Vitro Characterization
Vitamin D-Loaded Lipid Nanoparticles for Potential Treatment of Vitiligo: Preparation, Optimization, and In Vitro Characterization Open
Vitamin D3-loaded lipid nanoparticles (Vit D3-LNP), integrated into an azulene cream, were developed to enhance the topical delivery and stability of Vitamin D3. The LNP was formulated using a lipid mixture and hot homogenization-ultrasoni…
View article: Transurethral migration of vesical gossypiboma following open prostatectomy: a case report and review of the literature
Transurethral migration of vesical gossypiboma following open prostatectomy: a case report and review of the literature Open
Gossypiboma refers to a retained surgical sponge within the body after a surgical procedure. It is commonly reported in the abdominal cavity and is rare in the urinary bladder (vesical gossypiboma). There are only a few reports of vesical …
View article: Physiological Role of Targeting of the Receptor for Advanced Glycation End Products and Its Involvement in Severe Acute Pancreatitis
Physiological Role of Targeting of the Receptor for Advanced Glycation End Products and Its Involvement in Severe Acute Pancreatitis Open
Leukocyte infiltration and damage to pancreatic acinar cells serve as key indicators of severeacute pancreatitis (AP) [1]. However, the signaling pathways involved in pancreaticinflammation and tissue damage remain unclear. This study expl…
View article: Role of skin enzymes in metabolism of topical drugs
Role of skin enzymes in metabolism of topical drugs Open
Topical drugs have gained a lot of interest with their massive market growth and are available in various dosage forms. Prodrug compounds of transdermal delivery systems can be very different and designed to convert into the form of active…
View article: Strategic Approaches in Formulation Development for Atopic Dermatitis
Strategic Approaches in Formulation Development for Atopic Dermatitis Open
Atopic dermatitis (AD) is the most common chronic skin disease, significantly impacting patients’ quality of life. One of the most effective management approaches for AD involves addressing the defective skin barrier by urging AD patients …
View article: Mesenchymal stem cell membrane-coated nanoconstructs: why have they not yet found a home in clinical practice?
Mesenchymal stem cell membrane-coated nanoconstructs: why have they not yet found a home in clinical practice? Open
Keywords: : bioavailabilitybiodistributionbiomimeticclinical translationmesenchymal stem cell membranemesenchymal stem cellsMSCM-nanoconstructsnanodecoysnanoparticlesscalabilitytoxicological study
View article: Computational and biological approaches in repurposing ribavirin for lung cancer treatment: Unveiling antitumorigenic strategies
Computational and biological approaches in repurposing ribavirin for lung cancer treatment: Unveiling antitumorigenic strategies Open
Lung cancer is among leading causes of death worldwide. The five-year survival rate of this disease is extremely low (17.8 %), mainly due to difficult early diagnosis and to the limited efficacy of currently available chemotherapeutics. Th…
View article: Gamma scintigraphy in sensing drug delivery systems
Gamma scintigraphy in sensing drug delivery systems Open
The development and assessment of pharmaceutical dosage forms make considerable use of gamma-scintigraphy. Gamma scintigraphy is an imaging technique that is integrated with CT to assess and evaluate the targeting of drugs to various deliv…
View article: Enhancement of drug permeation across skin through stratum corneum ablation
Enhancement of drug permeation across skin through stratum corneum ablation Open
Stratum corneum (SC) ablation presents a promising strategy to enhance transdermal drug delivery (TDD) by temporary removing the skin's outermost barrier facilitating improved absorption of therapeutic agents.
View article: Innovative Approaches for Maintaining and Enhancing Skin Health and Managing Skin Diseases through Microbiome-Targeted Strategies
Innovative Approaches for Maintaining and Enhancing Skin Health and Managing Skin Diseases through Microbiome-Targeted Strategies Open
The skin microbiome is crucial in maintaining skin health, and its disruption is associated with various skin diseases. Prebiotics are non-digestible fibers and compounds found in certain foods that promote the activity and growth of benef…
View article: Porous silicon embedded in a thermoresponsive hydrogel for intranasal delivery of lipophilic drugs to treat rhinosinusitis
Porous silicon embedded in a thermoresponsive hydrogel for intranasal delivery of lipophilic drugs to treat rhinosinusitis Open
Intranasal delivery is the most preferred route of drug administration for treatment of a range of nasal conditions including chronic rhinosinusitis (CRS), caused by an infection and inflammation of the nasal mucosa. However, localised del…
View article: Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review
Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review Open
Vitamin D is one significant prohormone substance in human organ systems. It is a steroidal hormone produced in the skin upon exposure to UVB rays. This paper presents a systematic review of the utilization of topical vitamin D, specifical…
View article: Human Skin Drug Metabolism: Relationships between Methyl Salicylate Metabolism and Esterase Activities in IVPT Skin Membranes
Human Skin Drug Metabolism: Relationships between Methyl Salicylate Metabolism and Esterase Activities in IVPT Skin Membranes Open
The presence of esterase enzymes in human skin and their role in drug metabolism has been reported, but their distribution in the various skin layers and the relative contributions of those layers to metabolism is poorly defined. To gain f…
View article: Metamorphosis of Topical Semisolid Products—Understanding the Role of Rheological Properties in Drug Permeation under the “in Use” Condition
Metamorphosis of Topical Semisolid Products—Understanding the Role of Rheological Properties in Drug Permeation under the “in Use” Condition Open
When developing topical semisolid products, it is crucial to consider the metamorphosis of the formulation under the “in use” condition. Numerous critical quality characteristics, including rheological properties, thermodynamic activity, p…
View article: Vitiligo: A Review of Aetiology, Pathogenesis, Treatment, and Psychosocial Impact
Vitiligo: A Review of Aetiology, Pathogenesis, Treatment, and Psychosocial Impact Open
Vitiligo is an acquired, chronic condition characterised by depigmentation of the epidermis or by destruction/loss of melanin. Skin cells (melanocytes) are responsible for producing melanin, the substance that gives pigmentation to the ski…