Yusuf Dogus Dogru
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View article: 7942 Evolution of Insulin, Insulin-like Growth Factor and Their Cognate Receptors in Vertebrates, Invertebrates and Viruses
7942 Evolution of Insulin, Insulin-like Growth Factor and Their Cognate Receptors in Vertebrates, Invertebrates and Viruses Open
Disclosure: M. Chrudinova: None. Y.D. Dogru: None. R. Huang: None. R. Reiners: None. P. De Meyts: None. J. DaCosta: None. E. Altindis: None. The insulin/insulin-like growth factor (IGF) signaling system is an evolutionarily conserved syste…
View article: 12389 Viral Insulin/IGF-1-like Peptides: A New Dimension In Understanding The Insulin/IGF System
12389 Viral Insulin/IGF-1-like Peptides: A New Dimension In Understanding The Insulin/IGF System Open
Disclosure: M. Chrudinova: None. A. Chuard: None. F. Zhang: None. Y.D. Dogru: None. P. De Meyts: None. J.K. Kim: None. N. Kirk: None. J. Jiracek: None. R.D. DiMarchi: None. E. Altindis: None. Viral Insulin/IGF-1-Like Peptides: A New Dimens…
View article: The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes Onset
The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes Onset Open
Type 1 Diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. The insulin B-chain 9-23 (insB:9-23) peptide is established as a critical epitope in triggering T1D. In our previous study…
View article: Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease
Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease Open
Background Celiac disease (CD) is an autoimmune disorder triggered by gluten consumption. Almost all CD patients possess human leukocyte antigen (HLA) DQ2/DQ8 haplotypes; however, only a small subset of individuals carrying these alleles d…
View article: Additional file 1 of Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease
Additional file 1 of Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease Open
Additional file 1: Figure S1. Flow chart describing CD progressors demographics and sample size. Figure S2. Violin plot representation of most enriched genus/species in CD progressors compared to healthy controls. A. Fold change in ASVs at…
View article: Additional file 2 of Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease
Additional file 2 of Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease Open
Additional file 2: Table S1. Detailed Cohort and Fecal Sample Information copy. Table S2. Complete 16S Taxonomy Data and Analysis. Table S3. Relative Abundance Analysis. Table S4. IgA Targeted ASVs in CD Progressors at 2.5 and 5. Table S5.…
View article: Viruses and Metabolism: The Effects of Viral Infections and Viral Insulins on Host Metabolism
Viruses and Metabolism: The Effects of Viral Infections and Viral Insulins on Host Metabolism Open
Over the past decades, there have been tremendous efforts to understand the cross-talk between viruses and host metabolism. Several studies have elucidated the mechanisms through which viral infections manipulate metabolic pathways includi…
View article: Dynamics of Gut Microbiome, IgA Response and Plasma Metabolome in Development of Pediatric Celiac Disease
Dynamics of Gut Microbiome, IgA Response and Plasma Metabolome in Development of Pediatric Celiac Disease Open
SUMMARY Celiac disease (CD) is an autoimmune disorder triggered by gluten consumption. To identify the role of gut microbes in CD onset, we performed a longitudinal study focusing on two important phases of gut microbiota development at ag…