Yusuke Demizu
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View article: Space-making Particle Therapy Using Bioabsorbable Spacer for Bone and Soft Tissue Sarcomas: Two-institution Experience
Space-making Particle Therapy Using Bioabsorbable Spacer for Bone and Soft Tissue Sarcomas: Two-institution Experience Open
SMPT using a BAS appears effective and safe for treating BSTSs near critical organs, enabling curative dosing with minimal toxicity. Longer follow-up is needed to assess long-term outcomes.
View article: Combination Treatment with Spacer Placement Surgery Followed by Particle Radiotherapy for Lymph Node Metastasis from Uterine Cancer
Combination Treatment with Spacer Placement Surgery Followed by Particle Radiotherapy for Lymph Node Metastasis from Uterine Cancer Open
Background The effectiveness of local treatment in lymph node metastasis from uterine cancer has been proven; the standard treatment is surgical intervention. Although radiotherapy, including particle radiotherapy (PRT), is an alternative …
View article: A Case of Unresectable Hepatocellular Carcinoma Treated with Spacer Placement Surgery with Bioabsorbable Spacer and Subsequent Proton Beam Therapy
A Case of Unresectable Hepatocellular Carcinoma Treated with Spacer Placement Surgery with Bioabsorbable Spacer and Subsequent Proton Beam Therapy Open
Bioabsorbable spacer placement surgery and subsequent PBT are feasible and promising treatment options for unresectable HCC with impaired liver function.
View article: Proton Radiotherapy with Induction Chemotherapy for Locally Advanced Pancreatic Cancer: A Retrospective Analysis of Treatment Strategy and Outcomes
Proton Radiotherapy with Induction Chemotherapy for Locally Advanced Pancreatic Cancer: A Retrospective Analysis of Treatment Strategy and Outcomes Open
View article: Investigation on the Semi-synthetic Cannabinoids Distributed on the Internet in Japan: Reduced Forms or Acetyl Derivatives of Tetrahydrocannabinol (THC)
Investigation on the Semi-synthetic Cannabinoids Distributed on the Internet in Japan: Reduced Forms or Acetyl Derivatives of Tetrahydrocannabinol (THC) Open
Introduction: In recent years, products containing structurally similar substances to ∆9-tetrahydrocannbinol (∆9-THC), the main constituent for the hallucinogenic effects of cannabis, have been widely distributed through the internet. Hexa…
View article: Definitive particle therapy using protons or carbon ions for dedifferentiated liposarcoma
Definitive particle therapy using protons or carbon ions for dedifferentiated liposarcoma Open
Particle therapy using protons or carbon ions for the treatment of DDLS is safe and provides good OS and LC. However, further studies with longer follow-up periods and larger cohorts are warranted.
View article: First report of retroperitoneal rhabdomyosarcoma treated with space-making particle therapy for preservation of renal function
First report of retroperitoneal rhabdomyosarcoma treated with space-making particle therapy for preservation of renal function Open
View article: SPACE-MAKING PARTICLE THERAPY (SMPT) USING BIOABSORBABLE SPACER FOR PEDIATRIC PATIENTS
SPACE-MAKING PARTICLE THERAPY (SMPT) USING BIOABSORBABLE SPACER FOR PEDIATRIC PATIENTS Open
View article: Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy
Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy Open
Background Spacer placement surgery is useful in particle therapy (PT) for patients with abdominopelvic malignant tumors located adjacent to the gastrointestinal tract. This study aimed to assess the safety, efficacy, and long-term outcome…
View article: Comparison of passive-scattered and intensity-modulated proton beam therapy of craniospinal irradiation with proton beams for pediatric and young adult patients with brain tumors
Comparison of passive-scattered and intensity-modulated proton beam therapy of craniospinal irradiation with proton beams for pediatric and young adult patients with brain tumors Open
Purpose To investigate the dose stability of craniospinal irradiation based on irradiation method of proton beam therapy (PBT). Methods and materials Twenty-four pediatric and young adult brain tumor patients (age: 1–24 years) were examine…
View article: Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy
Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy Open
Background: Spacer placement surgery is useful in particle therapy (PT) for patients with abdominopelvic malignant tumors located adjacent to the gastrointestinal tract. This study aimed to assess the safety, efficacy, and long-term outcom…
View article: Comparison of Craniospinal Irradiation Using Proton Beams According to Irradiation Method and Initial Experience Treating Pediatric Patients
Comparison of Craniospinal Irradiation Using Proton Beams According to Irradiation Method and Initial Experience Treating Pediatric Patients Open
IMPT is better than PSPT at reducing the dose to the lens. The VBS technique can decrease the doses to neck-chest-abdomen organs. The PTV coverage of IMPT is superior to that of PSPT.
View article: Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review
Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review Open
Soft tissue myoepithelial carcinoma (MEC) is an extremely rare mesenchymal tumor that has a poor prognosis unless complete surgical resection is achieved. The present study reported a case of a 38-year-old woman with a tumor in the left pa…
View article: Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan
Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan Open
This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 speci…
View article: Multicenter study of re‐irradiation using carbon‐ions for head and neck malignancies after photon radiotherapy
Multicenter study of re‐irradiation using carbon‐ions for head and neck malignancies after photon radiotherapy Open
Purpose The goal of this multicenter retrospective study of patients with head and neck malignancies was to evaluate the efficacy and safety of carbon‐ion (C‐ion) radiotherapy (RT) after photon RT. Methods We enrolled 56 patients with head…
View article: Proton Beam Therapy for Unresectable Perihilar Cholangiocarcinoma
Proton Beam Therapy for Unresectable Perihilar Cholangiocarcinoma Open
Background : The outcomes of chemotherapy for patients with perihilar cholangiocarcinoma (PHC) are unsatisfactory, and photon therapy for unresectable PHC reportedly results in improved outcomes. Proton beam therapy (PBT) can be a treatmen…
View article: The comparison of acute toxicities associated with craniospinal irradiation between photon beam therapy and proton beam therapy in children with brain tumors
The comparison of acute toxicities associated with craniospinal irradiation between photon beam therapy and proton beam therapy in children with brain tumors Open
Introduction This study aimed to evaluate acute toxicities associated with irradiation between the X‐CSI (photon beam craniospinal irradiation) and P‐CSI (proton beam craniospinal irradiation) groups in children with brain tumors. Methods …
View article: Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic sarcoma of the 11th thoracic spine: a case report
Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic sarcoma of the 11th thoracic spine: a case report Open
Objective: Primary undifferentiated pleomorphic sarcoma (UPS) of the bone is rare. However, the common sites are the knee and proximal femur and humerus, while spinal involvement is rare. We report a case of primary UPS of the 11th …
View article: Current status of particle cancer board
Current status of particle cancer board Open
頭頸部領域悪性腫瘍に対する粒子線治療は主に非扁平上皮癌に対して2018年4月より保険収載となった。保険適応基準は切除による根治困難症例であり，手術適応の有無が重要となる。当院では2017年5月より兵庫県粒子線医療センター，兵庫県粒子線医療センター付属神戸陽子線センターと合同でキャンサーボードを行い，その治療適応について協議している。 今回我々はキャンサーボードについて，取り扱った症例数の推移とその内容について検討した。2017年5月から2020年12月まで208症例について…
View article: Simulation study using the spots deletion technique in spot scanning proton beam therapy for prostate cancers
Simulation study using the spots deletion technique in spot scanning proton beam therapy for prostate cancers Open
The aim of the present study was to investigate the effects on the dose distribution and beam delivery time in spot scanning proton beam therapy (PBT) incorporating the spot deletion technique. A spot scanning plan was created for 30 patie…
View article: Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED): a retrospective multi-institutional study
Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED): a retrospective multi-institutional study Open
View article: Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors
Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors Open
The present study simulated the effect of spot-scanning proton beam therapy (PBT) performed using a device equipped with a multi-leaf collimator (MLC) to calculate the dose distribution. Simulation studies using 18 pediatric patients with …
View article: Salvage hepatectomy for local recurrence after particle therapy using proton and carbon ion beams for liver cancer
Salvage hepatectomy for local recurrence after particle therapy using proton and carbon ion beams for liver cancer Open
Aim With the increased use of particle therapy for liver cancer, local recurrence after particle therapy increased. Salvage hepatectomy is an acceptable treatment option for local recurrence following particle therapy; however, its safety …
View article: Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines
Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines Open
View article: Surgical spacer placement for proton radiotherapy in locally advanced pancreatic body and tail cancers: initial clinical results
Surgical spacer placement for proton radiotherapy in locally advanced pancreatic body and tail cancers: initial clinical results Open
View article: Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study
Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study Open
IMRT with appropriate spacer placement may help provide high-dose treatment for LAPC and improve associated patient outcomes.
View article: A case of treatment related death caused by mucosal necrosis, brain necrosis and osteonecrosis after carbon ion radiotherapy in nasopharyngeal adenoid cystic carcinoma
A case of treatment related death caused by mucosal necrosis, brain necrosis and osteonecrosis after carbon ion radiotherapy in nasopharyngeal adenoid cystic carcinoma Open
症例は，41歳男性。上咽頭腺様嚢胞癌（cT4aN0M0）に対して炭素イオン線治療［総線量65Gy（RBE），25回分割照射］を行った。治療終了後，腫瘍は消失し完全奏功を得た。治療終了30ヶ月後，晩期有害事象として粘膜壊死と脳壊死を認めた。ステロイドの内服加療を行ったが，脳壊死は増悪し，頭蓋底骨と頸椎骨の壊死が生じた。治療終了後54ヶ月目に，粘膜壊死・脳壊死・頭蓋底骨と頸椎骨の壊死により生じた頭蓋内感染により死亡した。病理解剖では，腺様嚢胞癌の再発は認められなかった。炭素イオ…
View article: Multicenter Study of Carbon-ion Radiotherapy for Oropharyngeal Non-squamous Cell Carcinoma
Multicenter Study of Carbon-ion Radiotherapy for Oropharyngeal Non-squamous Cell Carcinoma Open
Carbon-ion radiotherapy appears to be a promising treatment option for oropharyngeal non-squamous cell carcinoma.
View article: Space-making particle therapy for unresectable hilar cholangiocarcinoma
Space-making particle therapy for unresectable hilar cholangiocarcinoma Open
Background Although the primary treatment option for hilar cholangiocarcinoma (HC) has been surgical resection, most patients present with unresectable advanced tumors at the time of diagnosis. Particle therapy (PT) holds a great potential…
View article: RONC-04. RE-IRRADIATION AFTER TREATMENT OF MEDULLOBLASTOMA; RELAPSED CASES AND SECOND CANCER CASES
RONC-04. RE-IRRADIATION AFTER TREATMENT OF MEDULLOBLASTOMA; RELAPSED CASES AND SECOND CANCER CASES Open
PURPOSE Late complications such as brainstem necrosis are great concern of re-irradiation for brain tumor. Proton beam therapy can reduce radiation dose of organs at risk such as brainstem, so is expected to reduce late complications. PATI…