Yusuke Hiki
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View article: Mixing features of transcription factors and genes enables accurate prediction of gene regulation relationships for unknown transcription factors
Mixing features of transcription factors and genes enables accurate prediction of gene regulation relationships for unknown transcription factors Open
Identifying regulatory relationships between transcription factors (TFs) and genes is essential to understand diverse biological phenomena related to gene expression. Recently, deep learning–based models to predict TFs that bind to genes f…
View article: Asynchronous Batch Bayesian Optimization with Pipelining Evaluations for Experimental Resource$\unicode{x2013}$constrained Conditions
Asynchronous Batch Bayesian Optimization with Pipelining Evaluations for Experimental Resource$\unicode{x2013}$constrained Conditions Open
Bayesian optimization is efficient even with a small amount of data and is used in engineering and in science, including biology and chemistry. In Bayesian optimization, a parameterized model with an uncertainty is fitted to explain the ex…
View article: A deep position-encoding model for predicting olfactory perception from molecular structures and electrostatics
A deep position-encoding model for predicting olfactory perception from molecular structures and electrostatics Open
View article: Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches
Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches Open
Introduction The COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop int…
View article: Mol-PECO: a deep learning model to predict human olfactory perception from molecular structures
Mol-PECO: a deep learning model to predict human olfactory perception from molecular structures Open
While visual and auditory information conveyed by wavelength of light and frequency of sound have been decoded, predicting olfactory information encoded by the combination of odorants remains challenging due to the unknown and potentially …
View article: A versatile and interoperable computational framework for the analysis and modeling of COVID-19 disease mechanisms
A versatile and interoperable computational framework for the analysis and modeling of COVID-19 disease mechanisms Open
The COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop interoperable bi…
View article: Erratum To: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms
Erratum To: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open
View article: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms
COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open
View article: Cas9-mediated genome editing reveals a significant contribution of calcium signaling pathways to anhydrobiosis in Pv11 cells
Cas9-mediated genome editing reveals a significant contribution of calcium signaling pathways to anhydrobiosis in Pv11 cells Open
View article: COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms Open
View article: Genome-Wide Role of HSF1 in Transcriptional Regulation of Desiccation Tolerance in the Anhydrobiotic Cell Line, Pv11
Genome-Wide Role of HSF1 in Transcriptional Regulation of Desiccation Tolerance in the Anhydrobiotic Cell Line, Pv11 Open
The Pv11, an insect cell line established from the midge Polypedilum vanderplanki, is capable of extreme hypometabolic desiccation tolerance, so-called anhydrobiosis. We previously discovered that heat shock factor 1 (HSF1) contributes to …
View article: Genome-Wide Role of HSF1 in Transcriptional Regulation of Desiccation Tolerance in the Anhydrobiotic Cell Line, Pv11
Genome-Wide Role of HSF1 in Transcriptional Regulation of Desiccation Tolerance in the Anhydrobiotic Cell Line, Pv11 Open
Pv11, an insect cell line established from the midge Polypedilum vanderplanki, is capable of ametabolic desiccation tolerance, so-called anhydrobiosis. We previously discovered that heat shock factor 1 (HSF1) contributes to the acquisition…
View article: COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms
COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms Open
We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the COVID-19 Disease Map. We discuss the tools, platforms, and guidelines necessary for the dis…
View article: Cas9-mediated Genome Editing Reveals a Significant Contribution of Calcium Signaling Pathways to Anhydrobiosis in Pv11
Cas9-mediated Genome Editing Reveals a Significant Contribution of Calcium Signaling Pathways to Anhydrobiosis in Pv11 Open
Pv11 is an insect cell line established from the midge Polypedilum vanderplanki that exhibits an extreme desiccation tolerance known as anhydrobiosis. Pv11 has also an anhydrobiotic ability which is induced by trehalose treatment. Here we …
View article: Identification of a master transcription factor and a regulatory mechanism for desiccation tolerance in the anhydrobiotic cell line Pv11
Identification of a master transcription factor and a regulatory mechanism for desiccation tolerance in the anhydrobiotic cell line Pv11 Open
Water is essential for living organisms. Terrestrial organisms are incessantly exposed to the stress of losing water, desiccation stress. Avoiding the mortality caused by desiccation stress, many organisms acquired molecular mechanisms to …