Yusuke Okamoto
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View article: Impact of post-ablation pulmonary vein adhesions on robot-assisted thoracoscopic surgery lobectomy: a case report
Impact of post-ablation pulmonary vein adhesions on robot-assisted thoracoscopic surgery lobectomy: a case report Open
Background The prevalence of atrial fibrillation (AF) is increasing in Japan, largely because of the aging population. Catheter ablation, particularly pulmonary vein isolation, is a widely adopted intervention for maintaining sinus rhythm.…
View article: ALK-Positive Lung Adenocarcinoma With Suspected Transformation to Squamous Cell Carcinoma in Lymph Node Metastases
ALK-Positive Lung Adenocarcinoma With Suspected Transformation to Squamous Cell Carcinoma in Lymph Node Metastases Open
View article: Examining the Formalin Fixation Method for Maintaining High <scp>RNA</scp> Quality in Surgical Lung Specimens
Examining the Formalin Fixation Method for Maintaining High <span>RNA</span> Quality in Surgical Lung Specimens Open
Background Multiplex genetic testing is recommended when treating nonsmall cell lung cancer. A certain percentage of test failures in RNA assays owing to poor surgical specimen quality have been documented, and fixation failure is a possib…
View article: A case of dural arteriovenous fistula requiring differentiation from herpes simplex encephalitis
A case of dural arteriovenous fistula requiring differentiation from herpes simplex encephalitis Open
A 65-year-old man was admitted to our hospital following a sudden loss of consciousness and seizures. He presented with fever, and a head MRI revealed lesions in the left medial and lateral temporal lobes, as well as the thalamus. Initiall…
View article: Effects of 3‐4 Weeks of Multimodal Complex Treatment for Parkinson's Disease on Motor Function and Quality of Life:A Retrospective Study
Effects of 3‐4 Weeks of Multimodal Complex Treatment for Parkinson's Disease on Motor Function and Quality of Life:A Retrospective Study Open
Purpose: The effectiveness of multimodal complex treatment for Parkinson's disease (PD‐MCT) has recently attracted attention. However, there are differences in the PD‐MCT content across institutions. Therefore, we aimed to elucidate the ef…
View article: Current Status and Challenges of Gastrointestinal Endoscopy Diagnosis with AI
Current Status and Challenges of Gastrointestinal Endoscopy Diagnosis with AI Open
近年AIは様々な分野で活用され、医療においては特に画像診断支援領域でのAIが注目を集めている。消化管内視鏡領域でも社会実装が進んでおり、上部消化管領域では食道、胃の腫瘍性病変検出のAIが、下部消化管領域では大腸ポリープの検出や鑑別のAIが既に実臨床で使用されている。特に大腸ポリープ検出支援AIは複数製品が上市されており、リアルワールドでのAIの性能結果も徐々に明らかになってきている。本邦では消化管がん検診として、胃がんの内視鏡スクリーニングが施行されており、検査精度向上が報…
View article: Ectopic ACTH-producing Pulmonary Typical Carcinoid with Pneumocystis Pneumonia After Lobectomy: a Case Report
Ectopic ACTH-producing Pulmonary Typical Carcinoid with Pneumocystis Pneumonia After Lobectomy: a Case Report Open
背景．異所性ACTH産生腫瘍は肺悪性腫瘍，とりわけ神経内分泌腫瘍に多く，クッシング症候群を呈しやすいとされている．症例．82歳．女性．1ヶ月前より全身倦怠感，37℃台の発熱，下肢浮腫を認めていた．精査の結果ACTH依存性クッシング症候群が疑われた．胸部CTで左下葉S10に結節を認め異所性ACTH産生腫瘍が疑われ左下葉切除＋リンパ節郭清を施行した．病理診断は定型カルチノイドで，免疫染色でACTHが陽性でありACTH産生肺定型カルチノイドpT1bN0M0 stage IA2と診…
View article: Structure and Immunomodulatory Activity of Glycogen Derived from Honeybee Larvae (<i>Apis mellifera</i>)
Structure and Immunomodulatory Activity of Glycogen Derived from Honeybee Larvae (<i>Apis mellifera</i>) Open
Honeybee larvae have been recognized as nutrient-rich food in many countries. Although glycogen, a storage form of glucose in animals, is synthesized in honeybee larvae, there is no information on the structure of glycan and its biological…
View article: Immediate Effect of a Sitting-based Parkinson’s Dance Class on Parkinson’s Disease Patients
Immediate Effect of a Sitting-based Parkinson’s Dance Class on Parkinson’s Disease Patients Open
〔目的〕座位が主体で行われるパーキンソンダンス教室(PDダンス)がパーキンソン病患者の身体機能へ与える即時効果の検証を目的に実施した.〔対象と方法〕対象はPDダンスに参加したパーキンソン病患者24名とした.PDダンス前後でのTimed up & Go test(TUG)と歩行速度との結果を比較した.〔結果〕TUGはPDダンス後に有意な減少を認めた.また,歩行速度は有意な低下を認めた.歩行速度で2群に分けて歩行速度の変化を比較した結果,低速歩行群にのみ有意な歩行速度の上昇を認…
View article: The development of the robotic foot with human inspiration subtalar joint
The development of the robotic foot with human inspiration subtalar joint Open
Human subtalar joint has the functions of suppressing excessive rotation of body and impact of landing during walking. The purpose of this study is to realize these functions intothe robotic foot. We constructed a robot foot that imitated …
View article: Detection of Selenocyanate in Biological Samples by HPLC with Fluorescence Detection Using König Reaction
Detection of Selenocyanate in Biological Samples by HPLC with Fluorescence Detection Using König Reaction Open
We developed a simple and sensitive HPLC method for the determination of selenocyanate (SeCN-). The König reaction, which is generally used for the determination of cyanide and thiocyanate, was applied for the post-column detect…
View article: Identification of Chondroitin Sulfates Having Unique Structures from Shellfish Using Chondroitinase ACII
Identification of Chondroitin Sulfates Having Unique Structures from Shellfish Using Chondroitinase ACII Open
海洋生物、特に二枚貝は抗凝固薬ヘパリンの代替資源として知られている。コンドロイチン硫酸（CS）もヘパリンと同様に二枚貝から抽出されるが、CSの詳細な構造解析は行われなかった。近年、私達は11種の食用貝から抽出したCSをコンドロイチナーゼABC又はACIIで処理し、得られた不飽和二糖をHPLCで分析した。その結果、いくつかの貝類で、未同定ピークがコンドロイチナーゼABCではなくコンドロイチナーゼACII処理により検出された。バカガイのCSでは、グルクロン酸のC-3位にケラタン…
View article: Identification of Chondroitin Sulfates Having Unique Structures from Shellfish Using Chondroitinase ACII
Identification of Chondroitin Sulfates Having Unique Structures from Shellfish Using Chondroitinase ACII Open
Marine organisms, especially bivalve molluscs have been known as an alternative source of heparin, an anticoagulant. Although chondroitin sulfate (CS) can be also extracted together with heparin, the detailed glycan structures of CS have n…
View article: Nursing practice and clinical pharmacology of prednisolone therapy for children with nephrotic syndrome
Nursing practice and clinical pharmacology of prednisolone therapy for children with nephrotic syndrome Open
Background
View article: Analysis of side effect manifestation and coping behavior of rheumatoid arthritis outpatients on intravenous drip and subcutaneous injection treatment by biologics
Analysis of side effect manifestation and coping behavior of rheumatoid arthritis outpatients on intravenous drip and subcutaneous injection treatment by biologics Open
Background:While rheumatoid arthritis(RA) has become more treatable due to the introduction of biologics(Bio), when side effects occur,they are likely to be severe. Therefore, coping behaviors including pharmacotherapy and infection preven…
View article: [Regular Paper] Disaccharide Composition of Chondroitin Sulfate Derived from Lateolabrax japonicas
[Regular Paper] Disaccharide Composition of Chondroitin Sulfate Derived from Lateolabrax japonicas Open
コンドロイチン硫酸(CS) はグルクロン酸(GlcA) とN-アセチルガラクトサミン(GalNAc) が交互に結合し,各糖ヒドロキシ基の一部に硫酸基が付加した直鎖の酸性多糖類である.GlcA の一部がイズロン酸(IdoA) に変換されたCS 鎖はデルマタン硫酸(DS) と呼ばれる.CS およびDS はA-unit (GlcA/IdoA-Gal-NAc4S),B-unit (IdoA2S-GalNAc4S),C-unit (GlcA/IdoA-GalNAc6S),D-unit…
View article: CuZr shape memory alloy fabricated by spark plasma sintering
CuZr shape memory alloy fabricated by spark plasma sintering Open
A sintered compact of a near equi-atomic Zr-Cu alloy was fabricated by gas atomization and spark plasma sintering. The properties of the powder were investigated by means of scanning electron microscopy, a laser diffraction technique and X…
View article: Identification of keratan sulfate disaccharide at C-3 position of glucuronate of chondroitin sulfate from <i>Mactra chinensis</i>
Identification of keratan sulfate disaccharide at C-3 position of glucuronate of chondroitin sulfate from <i>Mactra chinensis</i> Open
Glycosaminoglycans (GAGs), including chondroitin sulfate (CS), dermatan sulfate, heparin, heparan sulfate and keratan sulfate (KS) are linear sulfated repeating disaccharide sequences containing hexosamine and uronic acid [or galactose (Ga…
View article: In-situ Simultaneous Soft X-ray Absorption and Emission Spectroscopy under Controlled Atmosphere and Temperature
In-situ Simultaneous Soft X-ray Absorption and Emission Spectroscopy under Controlled Atmosphere and Temperature Open
In-situ simultaneous measurement technique of soft X-ray absorption and X-ray emission spectroscopy, which was available for atmospheric pressure and high temperature, was developed. This technique is expected to provide direct information…
View article: A review of six cases of aggressive NK cell leukemia in our institute
A review of six cases of aggressive NK cell leukemia in our institute Open
View article: DeVIC chemotherapy is effective for patients with refractory or relapsed diffuse large B-cell lymphoma
DeVIC chemotherapy is effective for patients with refractory or relapsed diffuse large B-cell lymphoma Open
View article: Gender Specific Association between Serum Uric Acid and Diastolic Dysfunction
Gender Specific Association between Serum Uric Acid and Diastolic Dysfunction Open
View article: Takayasu Arteritis and Ulcerative Cutaneous Sarcoidosis
Takayasu Arteritis and Ulcerative Cutaneous Sarcoidosis Open
A 67-year-old woman was referred to our hospital due to a refractory lower extremity ulcer. Occlusion of the bilateral superficial femoral arteries and a difference (>50 mmHg) in blood pressure between the bilateral upper limbs were noted.…
View article: Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens
Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens Open
A 47-year-old woman with pancytopenia, excessive systemic lymphadenopathy and splenomegaly was referred to our hospital. The peripheral blood (PB) smear findings indicated neutropenia with lymphoid cells exhibiting hairy projections, while…
View article: Successful Treatment of Cardiac Lymphoma
Successful Treatment of Cardiac Lymphoma Open
A 72-year-old man presented to our hospital with a onemonth history of chest pain and dyspnea.Electrocardiography performed on admission showed atrial fibrillation, and a chest X-ray demonstrated a large mass in the thoracic cavity (Pictur…
View article: Multiple Myeloma Mimicking Liver Metastases
Multiple Myeloma Mimicking Liver Metastases Open
View article: Intraoperative marking of an impalpable pulmonary nodule using the Hybrid OR System
Intraoperative marking of an impalpable pulmonary nodule using the Hybrid OR System Open
術前検査で触知不能と予測される肺野末梢小型結節影に対して，我々はハイブリッド手術用X線撮影装置を使用して術中にその局在を確認する方法を行ってきたので報告する．Allura Xper FD20撮影装置とマグナス手術台を融合させたシステムを使用した．2013年7月より約1年間に17症例19病巣に対して本法を施行した．結節のサイズは3-20 mm，病巣指摘率は100%，最終病理診断は原発性肺癌8病巣，転移性肺腫瘍9病巣，良性2病巣であった．手術専用ベッドとリンクすることによって側…
View article: Gender Specific Association between Serum Fibroblast Growth Factor 23/α-Klotho and Coronary Artery and Aortic Valve Calcification
Gender Specific Association between Serum Fibroblast Growth Factor 23/α-Klotho and Coronary Artery and Aortic Valve Calcification Open
Among subjects with diagnosed or suspected CAD, serum FGF23 was positively associated with CAC in women and serum α-Klotho was positively associated with AVC in men independent of the confounding variables, including the renal function and…
View article: Circulating Fibroblast Growth Factor 23 Has a U-Shaped Association With Atrial Fibrillation Prevalence
Circulating Fibroblast Growth Factor 23 Has a U-Shaped Association With Atrial Fibrillation Prevalence Open
Serum FGF23 had a U-shaped relationship with prevalence of AF among Japanese cardiac patients, which was independent of other calcium/phosphate metabolism-related parameters and eGFR. Pathophysiology underlying the observed link, if at all…