Yusuke Shimoyama
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View article: Formation of Pharmaceutical Cocrystals and Control of Drug Solubility using Fatty Acids
Formation of Pharmaceutical Cocrystals and Control of Drug Solubility using Fatty Acids Open
View article: Application of supercritical carbon dioxide to synthesis of various surface-modified metal oxide nanoparticles
Application of supercritical carbon dioxide to synthesis of various surface-modified metal oxide nanoparticles Open
View article: Modular Multi‐Parametric and Portable Readout System for Point‐of‐Care Applications
Modular Multi‐Parametric and Portable Readout System for Point‐of‐Care Applications Open
A portable, battery‐powered, multi‐purpose readout system for combined optical and thermal measurements is presented. The system is modular with four independent input channels for different measurement schemes, allowing simultaneous multi…
View article: Enhanced extraction of surface-modified iron oxide nanoparticles using supercritical carbon dioxide
Enhanced extraction of surface-modified iron oxide nanoparticles using supercritical carbon dioxide Open
The extraction of iron oxide nanoparticles (IONPs) was performed using hexane, cyclohexane, cyclopentane, and supercritical carbon dioxide (scCO2) in batch, semi-batch, and semi-batch bubbling systems for both unmodified and fatty acid-mod…
View article: Analysis of the Dissolution Behavior of Theophylline and Its Cocrystal Using ATR-FTIR Spectroscopic Imaging
Analysis of the Dissolution Behavior of Theophylline and Its Cocrystal Using ATR-FTIR Spectroscopic Imaging Open
Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic imaging is a powerful tool to visualize the distribution of components, and it has been used to analyze drug release from tablets. In this work, ATR-FTIR spect…
View article: Flow synthesis of silver nanoparticles using water in supercritical CO2 emulsion
Flow synthesis of silver nanoparticles using water in supercritical CO2 emulsion Open
Rapid and continuous synthesis of metal nanoparticles using green solvent system is still a serious challenge for both fundamental and practical research. In this work, we report a new flow process using water in supercritical CO2 (w/scCO2…
View article: High-Concentrated Synthesis of Surface Modified Iron Oxide Nanoparticles Using Ethanol-Enhanced Supercritical Co2 Media
High-Concentrated Synthesis of Surface Modified Iron Oxide Nanoparticles Using Ethanol-Enhanced Supercritical Co2 Media Open
View article: Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis
Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis Open
Background and Purpose Colorectal cancer progression from adenoma to cancer is a time‐intensive process; however, the interaction between normal fibroblasts (NFs) with early colorectal tumors, such as adenomas, remains unclear. Here, we an…
View article: Unlocking the Potential: Supercritical Carbon Dioxide Extraction of Surface-Modified Iron Oxide Nanoparticles Surpasses Organic Solvents
Unlocking the Potential: Supercritical Carbon Dioxide Extraction of Surface-Modified Iron Oxide Nanoparticles Surpasses Organic Solvents Open
View article: Low temperature synthesis of ZnO particles using a CO<sub>2</sub>-driven mechanism under high pressure
Low temperature synthesis of ZnO particles using a CO<sub>2</sub>-driven mechanism under high pressure Open
Low temperature synthesis of ZnO particles using a new reaction mechanism driven by supercritical CO 2 .
View article: Correlations to Estimate the Pure Solid Mean Particle Size in Supercritical Antisolvent Processes
Correlations to Estimate the Pure Solid Mean Particle Size in Supercritical Antisolvent Processes Open
View article: Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan
Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan Open
The usefulness of NUDT15 genotyping as a pharmacogenomic test for thiopurine has been established. The first such test developed to date, NUDT15 genotyping was approved for reimbursement in Japan in February 2019 for all indicated patients…
View article: Pharmaceutical Cocrystal Formation Using Lipid Media
Pharmaceutical Cocrystal Formation Using Lipid Media Open
Pharmaceutical cocrystal is expected to improve its bioavailability in human body. There are several drawbacks of using a large amount of organic solvent and heating operation for removing the solvent on conventional cocrystal formation te…
View article: Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release
Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release Open
View article: Flow Synthesis of Silver Nanoparticles Using Water in Supercritical Co2 Emulsion
Flow Synthesis of Silver Nanoparticles Using Water in Supercritical Co2 Emulsion Open
View article: Supplementary Material for: Effectiveness of antibiotics for uncomplicated diverticulitis: A retrospective investigation using a nationwide database in Japan
Supplementary Material for: Effectiveness of antibiotics for uncomplicated diverticulitis: A retrospective investigation using a nationwide database in Japan Open
Introduction: The efficacy of antibiotics for diverticulitis without abscess or peritonitis (uncomplicated diverticulitis) is controversial. We aimed to investigate the effectiveness of antibiotics for uncomplicated diverticulitis. Methods…
View article: EP1276: USTEKINUMAB HAS COMPARABLE LONG-TERM EFFECTIVENESS AS ANTI-TNF AGENTS IN BIOLOGIC-NAÏVE PATIENTS WITH CROHN'S DISEASE
EP1276: USTEKINUMAB HAS COMPARABLE LONG-TERM EFFECTIVENESS AS ANTI-TNF AGENTS IN BIOLOGIC-NAÏVE PATIENTS WITH CROHN'S DISEASE Open
View article: Synthesis of surface-modified iron oxide nanocrystals using supercritical carbon dioxide as the reaction field
Synthesis of surface-modified iron oxide nanocrystals using supercritical carbon dioxide as the reaction field Open
We applied the supercritical CO 2 technology, which is an excellent solventless process, to the synthesis of surface-modified iron oxide nanocrystals.
View article: High-pressure CO<sub>2</sub> for lipid-mediated cocrystallization of theophylline and nicotinamide
High-pressure CO<sub>2</sub> for lipid-mediated cocrystallization of theophylline and nicotinamide Open
In order to improve solubility and dissolution rate of pharmaceutical products in human body, the cocrystal formation has been focused on.The cocrystal allows to form the new crystal structure composed of active pharmaceutical ingredients …
View article: Supercritical Extraction Using Microfluidic System
Supercritical Extraction Using Microfluidic System Open
Supercritical extraction can be applied for separation and purification of bioactive compounds in pharmaceutical and cosmetic fields. Recently, microfluidic system has been utilized for the supercritical extraction because of controllable …
View article: Modeling of CO<sub>2</sub>-Activated Adsorption on Chitosan Hydrogel for Dye Removal in Aqueous Solution
Modeling of CO<sub>2</sub>-Activated Adsorption on Chitosan Hydrogel for Dye Removal in Aqueous Solution Open
This work focuses on adsorption kinetics and isotherm modelling in CO2-activated chitosan. Removal efficiency and adsorption capacity were measured for three anionic dyes: Brilliant Blue FCF (BBF), Congo Red (CR), Orange II (O-II) and one …
View article: CO<sub>2</sub>-Activated Adsorption: A New Approach to Dye Removal by Chitosan Hydrogel
CO<sub>2</sub>-Activated Adsorption: A New Approach to Dye Removal by Chitosan Hydrogel Open
This study focuses on development of a new adsorption technique by CO2-activated chitosan. Carbon dioxide was utilized to form the functional chemical groups of chitosan on the adsorptions of anionic dyes, Brilliant Blue FCF and…
View article: Giant superconducting fluctuations in the compensated semimetal FeSe at the BCS–BEC crossover
Giant superconducting fluctuations in the compensated semimetal FeSe at the BCS–BEC crossover Open
View article: Evolution of quasiparticle excitations with enhanced electron correlations in superconducting<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>A</mml:mi><mml:msub><mml:mi>Fe</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi>As</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:mrow></mml:math>(<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>A</mml:mi><mml:mo>=</mml:mo><mml:mi mathvariant="normal">K</mml:mi></mml:mrow></mml:math>, Rb, and Cs)
Evolution of quasiparticle excitations with enhanced electron correlations in superconducting(, Rb, and Cs) Open
In the heavily hole-doped iron-based superconductors $A$Fe$_2$As$_2$ ($A=$ K,\nRb, and Cs), the electron effective mass increases rapidly with alkali-ion\nradius. To study how the mass enhancement affects the superconducting state, we\nmea…
View article: Possible observation of highly itinerant quantum magnetic monopoles in the frustrated pyrochlore Yb2Ti2O7
Possible observation of highly itinerant quantum magnetic monopoles in the frustrated pyrochlore Yb2Ti2O7 Open
View article: Effect of Rapid Heating on Microwave-Assisted Synthesis of SAPO-34 Membranes
Effect of Rapid Heating on Microwave-Assisted Synthesis of SAPO-34 Membranes Open
近年，マイクロ波加熱（MW加熱）を利用した新たなゼオライト膜の開発が進められており，合成時間が短縮されることが報告されている．しかしながら，MW加熱がゼオライト膜形成過程におよぼす効果はいまだ明らかになっていない．本報告では，マイクロ波加熱および電気炉加熱（CE加熱）を利用し，濃度の異なる2種類の合成溶液からゼオライト類似化合物SAPO-34膜を合成し，その形成過程を比較した．その結果，MW加熱を利用することで，合成溶液の濃度によらずSAPO-34膜の初期形成が加速された．…