Yusuke Toyohara
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View article: Synthetic lethality from the combination of a histone methyltransferase SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma
Synthetic lethality from the combination of a histone methyltransferase SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma Open
OTS186935 inhibited double-strand DNA break repair, as evidenced by γH2AX downregulation by ChIP-seq and other assays. Combining OTS186935 with olaparib demonstrated activity resembling synthetic lethality; however, further validation is r…
View article: Clinical characteristics of bowel mucosal invasion in epithelial ovarian cancer
Clinical characteristics of bowel mucosal invasion in epithelial ovarian cancer Open
Background Bowel mucosal invasion epithelial ovarian cancer (EOC) is classified as stage IVB disease. The reason for this classification remains unclear, and clinical data on bowel mucosal invasion in EOC should be investigated. Methods We…
View article: BET inhibitor JQ1 induces apoptosis of ovarian and endometrial endometrioid carcinoma cells by downregulating <i>c‑Myc</i>
BET inhibitor JQ1 induces apoptosis of ovarian and endometrial endometrioid carcinoma cells by downregulating <i>c‑Myc</i> Open
Although ovarian endometrioid carcinoma (OEC), frequently associated with endometrial endometrioid carcinoma (EEC), is often diagnosed at an early stage, the prognosis remains poor. The development of new, effective drugs to target these c…
View article: Synthetic lethality from the combination of a histone methyltransferase, SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma
Synthetic lethality from the combination of a histone methyltransferase, SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma Open
Background: Uterine leiomyosarcoma (uLMS) has a poor prognosis owing to its high recurrence rate and resistance to chemotherapy. Therefore, novel therapeutic targets for uLMS need to be discovered. SUV39H2 is a histone methyltransferase th…
View article: Inhibition of protein arginine methyltransferase 6 activates interferon signaling and induces the apoptosis of endometrial cancer cells via histone modification
Inhibition of protein arginine methyltransferase 6 activates interferon signaling and induces the apoptosis of endometrial cancer cells via histone modification Open
Histone modification, a major epigenetic mechanism regulating gene expression through chromatin remodeling, introduces dynamic changes in chromatin architecture. Protein arginine methyltransferase 6 (PRMT6) is overexpressed in various type…
View article: The automatic diagnosis artificial intelligence system for preoperative magnetic resonance imaging of uterine sarcoma
The automatic diagnosis artificial intelligence system for preoperative magnetic resonance imaging of uterine sarcoma Open
Our newly established AI system automatically extracts tumor sites from MRI images and diagnoses them as uterine sarcomas without human intervention. Its accuracy is comparable to that of a radiologist. With further validation, the system …
View article: Identification of target cells of human papillomavirus 18 using squamocolumnar junction organoids
Identification of target cells of human papillomavirus 18 using squamocolumnar junction organoids Open
Human papillomavirus 18 (HPV18) is a highly malignant HPV genotype among high‐risk HPVs, characterized by the difficulty of detecting it in precancerous lesions and its high prevalence in adenocarcinomas. The cellular targets and molecular…
View article: Evolution of a surgical system using deep learning in minimally invasive surgery (Review)
Evolution of a surgical system using deep learning in minimally invasive surgery (Review) Open
Recently, artificial intelligence (AI) has been applied in various fields due to the development of new learning methods, such as deep learning, and the marked progress in computational processing speed. AI is also being applied in the med…
View article: Application of organoid culture from <scp>HPV18</scp>‐positive small cell carcinoma of the uterine cervix for precision medicine
Application of organoid culture from <span>HPV18</span>‐positive small cell carcinoma of the uterine cervix for precision medicine Open
Background Small cell carcinoma of the uterine cervix (SCCC) is a rare and highly malignant human papillomavirus (HPV)‐associated cancer in which human genes related to the integration site can serve as a target for precision medicine. The…
View article: Cells with stem‐like properties are associated with the development of <scp>HPV18</scp>‐positive cervical cancer
Cells with stem‐like properties are associated with the development of <span>HPV18</span>‐positive cervical cancer Open
The cellular origins of cervical cancer and the histological differentiation of human papillomavirus (HPV)‐infected cells remain unexplained. To gain new insights into the carcinogenesis and histological differentiation of HPV‐associated c…
View article: The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells
The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells Open
The histone methyltransferase SET domain-containing protein 8 (SETD8), which methylates histone H4 lysine 20 (H4K20) and non-histone proteins such as p53, plays key roles in human carcinogenesis. Our aim was to determine the involvement of…
View article: Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy
Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy Open
Endometrial cancer is a ubiquitous gynecological disease with increasing global incidence. Therefore, despite the lack of an established screening technique to date, early diagnosis of endometrial cancer assumes critical importance. This p…
View article: Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications
Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications Open
Endometrial cancer is one of the most frequently diagnosed gynecological malignancies worldwide. However, its prognosis in advanced stages is poor, and there are only few available treatment options when it recurs. Epigenetic changes in ge…