<title>Abstract</title> Background Bowel mucosal invasion epithelial ovarian cancer (EOC) is classified as stage IVB disease. The reason for this classification remains unclear, and clinical data on bowel mucosal invasion in EOC should be investigated. Methods We retrospectively reviewed data from patients with stage IVB EOC who presented at our hospital with bowel mucosal invasion between January 2011 and September 2023. Patients with bowel mucosal invasion and other factors associated with IVB EOC were excluded …

OTS186935 inhibited double-strand DNA break repair, as evidenced by γH2AX downregulation by ChIP-seq and other assays. Combining OTS186935 with olaparib demonstrated activity resembling synthetic lethality; however, further validation is required before clinical translation.

Histone modification, a major epigenetic mechanism regulating gene expression through chromatin remodeling, introduces dynamic changes in chromatin architecture. Protein arginine methyltransferase 6 (PRMT6) is overexpressed in various types of cancer, including prostate, lung and endometrial cancer (EC). Epigenome regulates the expression of endogenous retrovirus (ERV), which activates interferon signaling related to cancer. The antitumor effects of PRMT6 inhibition and the role of PRMT6 in EC were investigated, u…

Although ovarian endometrioid carcinoma (OEC), frequently associated with endometrial endometrioid carcinoma (EEC), is often diagnosed at an early stage, the prognosis remains poor. The development of new, effective drugs to target these cancers is highly desirable. The bromodomain and extra-terminal domain (BET) family proteins serve a role in regulating transcription by recognizing histone acetylation, which is implicated in several types of cancer. BET inhibitors have been reported as promising cancer drugs. Th…

<title>Abstract</title> <bold>Background:</bold> Uterine leiomyosarcoma (uLMS) has a poor prognosis owing to its high recurrence rate and resistance to chemotherapy. Therefore, novel therapeutic targets for uLMS need to be discovered. SUV39H2 is a histone methyltransferase that promotes the repair of double-stranded DNA breaks by recruiting phosphorylated H2AX (γH2AX). In this study, we investigated the potential therapeutic targets of SUV39H2 in uLMS and the mechanism of synthetic lethality between PARP inhibitor…