Yusuke Yumita
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View article: Effectiveness of the serum ratio of L-cysteine to glutathione for the prediction of cardiovascular events
Effectiveness of the serum ratio of L-cysteine to glutathione for the prediction of cardiovascular events Open
Aminothiols play an important role in the antioxidant defense system. Their serum profile may be a predictor of prognosis and cardiovascular events. This study followed-up 262 patients (202 men; age, 65 ± 13 years) who had been treated for…
View article: B-type natriuretic peptide levels predict long-term mortality in a large cohort of adults with congenital heart disease
B-type natriuretic peptide levels predict long-term mortality in a large cohort of adults with congenital heart disease Open
Background and Aims Many adult patients with congenital heart disease (ACHD) are still afflicted by premature death. Previous reports suggested natriuretic peptides may identify ACHD patients with adverse outcome. The study investigated pr…
View article: Sex Differences in Cardiac and Clinical Phenotypes and Their Relation to Outcomes in Patients with Heart Failure
Sex Differences in Cardiac and Clinical Phenotypes and Their Relation to Outcomes in Patients with Heart Failure Open
Biological sex is one of the major factors characterizing the heart failure (HF) patient phenotype. Understanding sex-related differences in HF is crucial to implement personalized care for HF patients with various phenotypes. There are se…
View article: Beyond Aortic Diameter for the Management of Thoracic Aortic Aneurysm
Beyond Aortic Diameter for the Management of Thoracic Aortic Aneurysm Open
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View article: β1 Adrenergic Receptor Autoantibodies and IgG Subclasses: Current Status and Unsolved Issues
β1 Adrenergic Receptor Autoantibodies and IgG Subclasses: Current Status and Unsolved Issues Open
A wide range of anti-myocardial autoantibodies have been reported since the 1970s. Among them, autoantibodies against the β1-adrenergic receptor (β1AR-AAb) have been the most thoroughly investigated, especially in dilated cardiomyopathy (D…
View article: Baseline and Serial BNP Measurements Predict Long-Term Mortality in Adults with Congenital Heart Disease: A study including 3,392 patients
Baseline and Serial BNP Measurements Predict Long-Term Mortality in Adults with Congenital Heart Disease: A study including 3,392 patients Open
Background Although there is an ever growing number of adult patients with congenital heart disease (ACHD), many are still afflicted by premature death. Previous reports suggested that natriuretic peptides may identify ACHD patients with a…
View article: A Low Arginine/Ornithine Ratio is Associated with Long-Term Cardiovascular Mortality
A Low Arginine/Ornithine Ratio is Associated with Long-Term Cardiovascular Mortality Open
A low L-arginine/L-ornithine ratio may be associated with increased 10-year cardiac mortality.
View article: D-Dimer beyond Diagnosis of Pulmonary Embolism: Its Implication for Long-Term Prognosis in Cardio-Oncology Era
D-Dimer beyond Diagnosis of Pulmonary Embolism: Its Implication for Long-Term Prognosis in Cardio-Oncology Era Open
Venous thromboembolism (VTE) is a common comorbidity of cancer, often referred to as cancer-associated thrombosis (CAT). Even though its prevalence has been increasing, its clinical picture has not been thoroughly investigated. In this sin…
View article: Endothelial Extracellular Signal‐Regulated Kinase/Thromboxane A2/Prostanoid Receptor Pathway Aggravates Endothelial Dysfunction and Insulin Resistance in a Mouse Model of Metabolic Syndrome
Endothelial Extracellular Signal‐Regulated Kinase/Thromboxane A2/Prostanoid Receptor Pathway Aggravates Endothelial Dysfunction and Insulin Resistance in a Mouse Model of Metabolic Syndrome Open
Background Metabolic syndrome is characterized by insulin resistance, which impairs intracellular signaling pathways and endothelial NO bioactivity, leading to cardiovascular complications. Extracellular signal‐regulated kinase (ERK) is a …
View article: Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure
Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure Open
Heart failure (HF) is a syndrome with global clinical and socioeconomic burden worldwide owing to its poor prognosis. Accumulating evidence has implicated the possible contribution of gut microbiota-derived metabolites, short-chain fatty a…
View article: Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction
Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction Open
The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E…
View article: “Target Heart Rate” calculated aiming at zero overlap of mitral E and A waves is useful for prediction of long-term outcome for patients with heart failure and reduced ejection fraction
“Target Heart Rate” calculated aiming at zero overlap of mitral E and A waves is useful for prediction of long-term outcome for patients with heart failure and reduced ejection fraction Open
Background Lower heart rate (HR) is associated with more favourable long-term outcome in patients with heart failure with reduced ejection fraction (HFrEF). However, an optimal threshold of HR remains unclear. Targeted HR (THR), defined by…