Explanipedia

A case of colorectal malakoplakia in a patient with cytomegalovirus-associated refractory ulcerative colitis Open

Shinichiro Kawatoko, Hidetaka Yamamoto, Yuta Fuyuno, Junji Umeno · 2025

Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study Open

Sho Suzuki, Naoyuki Tominaga, Tomonori Aoki, Eiji Sadashima, Tadashi Miike , et al. · 2024

The relationship between blood group and rebleeding in acute lower gastrointestinal bleeding (ALGIB) remains unclear. This study aimed to investigate the association between blood group O and clinical outcomes in patients with ALGIB. The s…

A novel prediction tool for mortality in patients with acute lower gastrointestinal bleeding requiring emergency hospitalization: a large multicenter study Open

Naoyuki Tominaga, Eiji Sadashima, Tomonori Aoki, Minoru Fujita, Katsumasa Kobayashi , et al. · 2024

MAINTENANCE EFFICACY OF ORAL INDIGO NATURALIS FOR ULCERATIVE COLITIS: A SINGLE-CENTER, OPEN-LABEL, RANDOMIZED, CONTROLLED STUDY Open

Yuichi Matsuno, Junji Umeno, Atsushi Hirano, Yuta Fuyuno, Tomohiro Nagasue , et al. · 2024

BACKGROUND Indigo naturalis (IN) is one of the herbal medicines in Chinese medicine. Recent reports have demonstrated a strong remission induction efficacy of oral IN in induction therapy for ulcerative colitis (UC), but the efficacy of IN…

Early feeding reduces length of hospital stay in patients with acute lower gastrointestinal bleeding: A large multicentre cohort study Open

Takaaki Kishino, Tomonori Aoki, Eiji Sadashima, Katsumasa Kobayashi, Atsushi Yamauchi , et al. · 2023

Aim No studies have compared the clinical outcomes of early and delayed feeding in patients with acute lower gastrointestinal bleeding (ALGIB). This study aimed to evaluate the benefits and risks of early feeding in a nationwide cohort of …

Disease Flares Following COVID-19 Vaccination in Patients with Inflammatory Bowel Disease Open

Yuichiro Yoshida, Shin Fujioka, Tomohiko Moriyama, Junji Umeno, Keisuke Kawasaki , et al. · 2023

Objective Flares of inflammatory bowel disease (IBD) can occur infrequently after vaccination for coronavirus disease 2019 (COVID-19), although the details of this phenomenon are poorly understood. To clarify the possibility of an unfavora…

A Novel Prediction Tool for Mortality in Patients with Acute Lower Gastrointestinal Bleeding: A Large Multicenter Long-Term Cohort Study Open

Naoyuki Tominaga, Eiji Sadashima, Tomonori Aoki, Minoru Fujita, Katsumasa Kobayashi , et al. · 2023

Acute lower gastrointestinal bleeding in patients with poor long-term prognoses requires careful follow-up. This study aimed to identify predictors of long-term mortality in patients with acute hematochezia and construct a prognostic tool …

Multicenter propensity score‐matched analysis comparing short <i>versus</i> long cap‐assisted colonoscopy for acute hematochezia Open

Mariko Kobayashi, Shintaro Akiyama, Toshiaki Narasaka, Katsumasa Kobayashi, Atsushi Yamauchi , et al. · 2023

Background and Aim While short and long attachment caps are available for colonoscopy, it is unclear which type is more appropriate for stigmata of recent hemorrhage (SRH) identification in acute hematochezia. This study aimed to compare t…

Small bowel capsule endoscopy examination and open access database with artificial intelligence: The SEE‐artificial intelligence project Open

Akihito Yokote, Junji Umeno, Keisuke Kawasaki, Shin Fujioka, Yuta Fuyuno , et al. · 2023

Objectives Artificial intelligence (AI) may be practical for image classification of small bowel capsule endoscopy (CE). However, creating a functional AI model is challenging. We attempted to create a dataset and an object detection CE AI…

Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study Open

Yoshinori Sato, Tomonori Aoki, Eiji Sadashima, Yusuke Nakamoto, Katsumasa Kobayashi , et al. · 2023

Ustekinumab Decreases Circulating Th17 Cells in Ulcerative Colitis Open

Noriyuki Imazu, Takehiro Torisu, Yutaro Ihara, Junji Umeno, Keisuke Kawasaki , et al. · 2023

Objective T helper (Th) cells play a central role in the pathogenesis of ulcerative colitis (UC). The present study analyzed the changes in circulating T cells by administration of ustekinumab (UST), an interleukin-12/23p40 antibody. Metho…

Outcomes and recurrent bleeding risks of detachable snare and band ligation for colonic diverticular bleeding: a multicenter retrospective cohort study Open

Atsushi Yamauchi, Naoki Ishii, Atsuo Yamada, Katsumasa Kobayashi, Jun Omori , et al. · 2023

There were no significant differences in outcomes between EDSL and EBL for CDB. After ligation therapy, careful follow-up is required, especially in the treatment of sigmoid diverticular bleeding during admission. History of ALGIB and perf…

P868 Clinical features of chronic enteropathy associated with SLCO2A1 gene Open

Junji Umeno, Yuta Fuyuno, Takehiro Torisu, Yuichi Matsuno, Motohiro Esaki , et al. · 2023

Background Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations of the SLCO2A1 gene which encodes a prostaglandin transporter. This disease is rare and intractable characterized by persist…

Supplementary Material for: LONG-HOSP score: a novel predictive score for length of hospital stay in acute lower gastrointestinal bleeding: a multicenter nationwide study Open

Minoru Fujita, Tomonori Aoki, Noriaki Manabe, Yuichi Ito, Katsumasa Kobayashi , et al. · 2023

Introduction: Length of stay (LOS) in hospital affects cost, patient quality of life, and hospital management; however, existing gastrointestinal bleeding models applicable at hospital admission have not focused on LOS. We aimed to constru…

Supplementary Material for: Weekend effect on clinical outcomes of acute lower gastrointestinal bleeding: A large multicenter cohort study in Japan Open

Junichi Hayasaka, Daisuke Kikuchi, Naoki Ishii, Katsumasa Kobayashi, Atsushi Yamauchi , et al. · 2023

Introduction Weekend admissions showed increased mortality in several medical conditions. This study aimed to examine the weekend effect on acute lower gastrointestinal bleeding (ALGIB) and its mortality and other outcomes. Methods This re…

LONG-HOSP Score: A Novel Predictive Score for Length of Hospital Stay in Acute Lower Gastrointestinal Bleeding – A Multicenter Nationwide Study Open

Minoru Fujita, Tomonori Aoki, Noriaki Manabe, Yoichiro Ito, Katsumasa Kobayashi , et al. · 2023

Introduction: Length of stay (LOS) in hospital affects cost, patient quality of life, and hospital management; however, existing gastrointestinal bleeding models applicable at hospital admission have not focused on LOS. We aimed to constru…

Weekend Effect on Clinical Outcomes of Acute Lower Gastrointestinal Bleeding: A Large Multicenter Cohort Study in Japan Open

Junnosuke Hayasaka, Daisuke Kikuchi, Naoki Ishii, Katsumasa Kobayashi, Atsushi Yamauchi , et al. · 2023

Introduction: Weekend admissions showed increased mortality in several medical conditions. This study aimed to examine the weekend effect on acute lower gastrointestinal bleeding (ALGIB) and its mortality and other outcomes. Methods: This …

Timing of colonoscopy in acute lower GI bleeding: a multicenter retrospective cohort study Open

Yasutoshi Shiratori, Naoki Ishii, Tomonori Aoki, Katsumasa Kobayashi, Atsushi Yamauchi , et al. · 2022

Early colonoscopy increased the rate of SRH identification and shortened the length of stay but involved an increased risk of rebleeding and did not improve mortality and IVR or surgery requirement. Early colonoscopy particularly benefited…

One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study Open

Yuichi Matsuno, Takehiro Torisu, Junji Umeno, Hiroki Shibata, Atsushi Hirano , et al. · 2022

Background/Aims: Recent studies suggested a favorable effect of indigo naturalis (IN) in inducing remission for refractory ulcerative colitis (UC), however, the maintenance effect of IN for patients with UC remains unknown. Therefore, we c…

Endoscopic direct clipping versus indirect clipping for colonic diverticular bleeding: A large multicenter cohort study Open

Takaaki Kishino, Naoyoshi Nagata, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada , et al. · 2022

Background Direct and indirect clipping treatments are used worldwide to treat colonic diverticular bleeding (CDB), but their effectiveness has not been examined in multicenter studies with more than 100 cases. Objective We sought to deter…

Supplementary Material for: The Compositional Structure of the Small Intestinal Microbial Community via Balloon-Assisted Enteroscopy Open

Tomohiro Nagasue, Atsushi Hirano, Takehiro Torisu, Junji Umeno, Hiroshi Shibata , et al. · 2022

Introduction: An association has been found between human-gut microbiota and various diseases (e.g., metabolic disease) by analyzing fecal or colonic microbiota. Despite the importance of the small intestinal microbiota, samp…

Role of barium enema examination for the diagnosis of submucosal invasion depth in T1 colorectal cancers Open

Keisuke Kawasaki, Takehiro Torisu, Takahisa Nagahata, Motohiro Esaki, Koichi Kurahara , et al. · 2021

Outcomes in high and low volume hospitals in patients with acute hematochezia in a cohort study Open

Naoki Ishii, Naoyoshi Nagata, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada , et al. · 2021

Outcomes of acute lower gastrointestinal bleeding have not been compared according to hospital capacity. We aimed to perform a propensity score-matched cohort study with path and mediation analyses for acute hematochezia patients. Hospital…

Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma Open

T Tanaka, Yuichi Matsuno, Takehiro Torisu, Hiroki Shibata, Atsushi Hirano , et al. · 2021

To investigate the mucosal microbiota in the stomach of patients with Helicobacter pylori -negative mucosa-associated lymphoid tissue (MALT) lymphoma by means of metagenomic analysis. Although some gastric MALT lymphomas are associated wit…

Identifying Bleeding Etiologies by Endoscopy Affected Outcomes in 10,342 Cases With Hematochezia: CODE BLUE-J Study Open

Naoyoshi Nagata, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Jun Omori , et al. · 2021

INTRODUCTION: The bleeding source of hematochezia is unknown without performing colonoscopy. We sought to identify whether colonoscopy is a risk-stratifying tool to identify etiology and predict outcomes and whether presenting symptoms can…

Risk of Rebleeding in Patients with Small Bowel Vascular Lesions Open

Akira Harada, Takehiro Torisu, Shin Fujioka, Yuichiro Yoshida, Yasuharu Okamoto , et al. · 2021

Objective With recent advances in endoscopic modalities, small bowel vascular lesions (SBVLs) are often now detected in patients with gastrointestinal bleeding. Given the high invasiveness of endoscopic treatment, it is important to select…

SLCO2A1 gene is the causal gene for both primary hypertrophic osteoarthropathy and hereditary chronic enteropathy Open

Junji Umeno, Takayuki Matsumoto, Yuta Fuyuno, Motohiro Esaki, Takehiro Torisu · 2021

Nationwide large-scale data of acute lower gastrointestinal bleeding in Japan uncover detailed etiologies and relevant outcomes: CODE BLUE J-Study Open

Naoyoshi Nagata, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Jun Omori , et al. · 2021

Background The value of endoscopy for acute lower GI bleeding (ALGIB) remains unclear, given few large cohort studies. We aim to provide detailed clinical data for ALGIB management and to identify patients at risk for adverse outcomes base…

Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations Open

Frauke Degenhardt, Gabriele Mayr, Mareike Wendorff, Gabrielle Boucher, Eva Ellinghaus , et al. · 2021

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD and specifica…

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