Yutaro Akiyama
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View article: POS1362 JANUS KINASE INHIBITOR SUPPRESSES TNF-α and IL-6-INDUCED OSTEOCLAST DIFFERENTIATION, BUT NOT RANKL-INDUCED OSTEOCLAST DIFFERENTIATION, AND REDUCES BONE DESTRUCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS
POS1362 JANUS KINASE INHIBITOR SUPPRESSES TNF-α and IL-6-INDUCED OSTEOCLAST DIFFERENTIATION, BUT NOT RANKL-INDUCED OSTEOCLAST DIFFERENTIATION, AND REDUCES BONE DESTRUCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS Open
View article: Carbamoyl phosphate synthetase 1 deficiency manifested in an adult treated with prednisone for polymyositis, and cured by live-donor liver transplantation
Carbamoyl phosphate synthetase 1 deficiency manifested in an adult treated with prednisone for polymyositis, and cured by live-donor liver transplantation Open
View article: COVID-19 severity and corticosteroid treatment have minimal effect on specific antibody production
COVID-19 severity and corticosteroid treatment have minimal effect on specific antibody production Open
View article: Progressive Severe Hemophagocytic Syndrome due to Disseminated Histoplasmosis in a Patient with HIV-1 Infection
Progressive Severe Hemophagocytic Syndrome due to Disseminated Histoplasmosis in a Patient with HIV-1 Infection Open
Histoplasmosis is caused by Histoplasma capsulatum and is prevalent in areas of the world where H. capsulatum is endemic. We herein report a patient diagnosed with human immunodeficiency virus-1 (HIV-1) who developed histoplasmosis from a …
View article: Urinary liver-type fatty acid–binding protein level as a prognostic indicator of acute kidney injury secondary to severe falciparum malaria
Urinary liver-type fatty acid–binding protein level as a prognostic indicator of acute kidney injury secondary to severe falciparum malaria Open
View article: COVID-19 severity and corticosteroid treatment have minimal effect on specific antibody production
COVID-19 severity and corticosteroid treatment have minimal effect on specific antibody production Open
Background Dexamethasone is currently administered for Coronavirus disease 2019(COVID-19); however, there are concerns about its effect on specific antibodies’ production. The aim of this study was to evaluate whether specific antibodies w…
View article: Pyelonephritis due to <i>Escherichia coli</i> in the older population in Japan: Impacts on activities of daily living and medical costs
Pyelonephritis due to <i>Escherichia coli</i> in the older population in Japan: Impacts on activities of daily living and medical costs Open
This study aimed to investigate differences in Activities of Daily Living (ADL), at admission and discharge, as well as the medical costs of pyelonephritis in older adults in Japan. Patients hospitalized for pyelonephritis between January …
View article: Efficacy and viral dynamics of tecovirimat in patients with MPOX: A multicenter open-label, double-arm trial in Japan
Efficacy and viral dynamics of tecovirimat in patients with MPOX: A multicenter open-label, double-arm trial in Japan Open
Early tecovirimat administration might reduce viral shedding duration, thereby mitigating infection spread. Moreover, patients infected with HIV showed prolonged viral shedding, increasing the transmission risk compared to those without HI…
View article: Aortic endograft infection by Mycobacterium abscessus subsp. massiliense with acquired clarithromycin resistance: a case report
Aortic endograft infection by Mycobacterium abscessus subsp. massiliense with acquired clarithromycin resistance: a case report Open
View article: Trends of participants in convalescent plasma donation for COVID-19 in Japan as the pandemic evolved
Trends of participants in convalescent plasma donation for COVID-19 in Japan as the pandemic evolved Open
As outbreaks of emerging infectious disease occur, it is desirable to construct and implement a scheme for convalescent plasma donation promptly and to monitor the eligibility rate over time. If it declines, promptly analyze and resolve th…
View article: Efficacy and Viral Dynamics of Tecovirimat in Patients with MPOX: A Multicenter Open-Label, Double-Arm Trial in Japan
Efficacy and Viral Dynamics of Tecovirimat in Patients with MPOX: A Multicenter Open-Label, Double-Arm Trial in Japan Open
Introduction Tecovirimat’s application in treating mpox remains under-researched, leaving gaps in clinical and virological understanding. Methods The Tecopox study, conducted in Japan, assessed the efficacy and safety of oral tecovirimat t…
View article: POS1042 JANUS KINASE INHIBITOR SUPPRESSES THE DIFFERENTIATION AND FUNCTION OF TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-6- INDUCED OSTEOCLASTS IN PERIPHERAL BLOOD MONOCYTES FROM PATIENTS WITH RHEUMATOID ARTHRITIS
POS1042 JANUS KINASE INHIBITOR SUPPRESSES THE DIFFERENTIATION AND FUNCTION OF TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-6- INDUCED OSTEOCLASTS IN PERIPHERAL BLOOD MONOCYTES FROM PATIENTS WITH RHEUMATOID ARTHRITIS Open
Background We have previously reported that stimulation of mouse bone marrow–derived macrophages with tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) induces differentiation of osteoclast-like cells having bone resorption ability<…
View article: Exacerbations of Idiopathic Systemic Capillary Leak Syndrome following BNT162b2 mRNA COVID-19 Vaccine (Pfizer-BioNTech)
Exacerbations of Idiopathic Systemic Capillary Leak Syndrome following BNT162b2 mRNA COVID-19 Vaccine (Pfizer-BioNTech) Open
A Japanese man experienced three episodes of hypovolemic shock and was diagnosed with systemic capillary leak syndrome (SCLS). He developed SCLS exacerbation 2 days after receiving a second dose of the Pfizer-BioNTech BNT162b2 mRNA COVID-1…
View article: Aortic endograft infection by Mycobacterium abscessus subsp. massiliense with acquired clarithromycin resistance is associated with unreported gene mutations: A case report
Aortic endograft infection by Mycobacterium abscessus subsp. massiliense with acquired clarithromycin resistance is associated with unreported gene mutations: A case report Open
Background Mycobacterium abscessus subsp. massiliense (MMA) comprises a group of non-tuberculous, rapidly growing mycobacteria. Although MMA can cause pulmonary diseases, surgical site infections, and disseminated diseases, aortic endograf…
View article: 2245. Urinary tract infections in the elderly population in Japan; long hospital stay, high medical costs, and decline in the activities of daily living scores
2245. Urinary tract infections in the elderly population in Japan; long hospital stay, high medical costs, and decline in the activities of daily living scores Open
Background Japan has one of the most aging societies in the world. Urinary tract infection (UTI) is a common disease in the elderly, and the incidence of hospitalization owing to UTI is increasing with the aging population. Here, we examin…
View article: Potential usage of anterior nasal sampling in clinical practice with three rapid antigen tests for SARS-CoV-2
Potential usage of anterior nasal sampling in clinical practice with three rapid antigen tests for SARS-CoV-2 Open
ESP, LUMI, and LUMI-P showed practical diagnostic accuracy for AN sampling compared to NP sampling. There was no significant factor affecting the concordance between AN and NP sampling for these rapid antigen tests.
View article: Interferon lambda 3 in the early phase of coronavirus disease‐19 can predict oxygen requirement
Interferon lambda 3 in the early phase of coronavirus disease‐19 can predict oxygen requirement Open
Since the coronavirus disease 2019 (COVID-19) pandemic started, various medications and vaccinations have been developed. However, the healthcare capacity was still exceeded during the period of rapid increase in COVID-19 cases, which hind…
View article: Risk factors associated with asymptomatic hypoxemia among COVID-19 patients: a retrospective study using the nationwide Japanese registry, COVIREGI-JP
Risk factors associated with asymptomatic hypoxemia among COVID-19 patients: a retrospective study using the nationwide Japanese registry, COVIREGI-JP Open
View article: Impact of newly diagnosed diabetes on coronavirus disease 2019 severity and hyperglycemia
Impact of newly diagnosed diabetes on coronavirus disease 2019 severity and hyperglycemia Open
Aims/Introduction Diabetes is associated with poor clinical outcomes of coronavirus disease 2019 (COVID‐19). However, the impact of newly diagnosed diabetes on prognosis has not been clarified. The objective of this study was to show the f…
View article: Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan
Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan Open
View article: Fatty liver on computed tomography scan on admission is a risk factor for severe coronavirus disease
Fatty liver on computed tomography scan on admission is a risk factor for severe coronavirus disease Open
View article: Clinical and radiological findings of silent hypoxia among COVID-19 patients
Clinical and radiological findings of silent hypoxia among COVID-19 patients Open
View article: A Pilot Study on Viral Load in Stool Samples of Patients with COVID-19 Suffering from Diarrhea
A Pilot Study on Viral Load in Stool Samples of Patients with COVID-19 Suffering from Diarrhea Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be detected in the stool samples of patients with coronavirus disease 2019 (COVID-19), and this virus can be transmitted via the oral-fecal route. However, there are only few…
View article: Clinical course of alopecia after COVID-19
Clinical course of alopecia after COVID-19 Open
View article: Evaluation of serum antibodies against SARS-CoV□2 in healthcare workers who participated in the operation of charter flights for the evacuation of Japanese residents from Hubei Province
Evaluation of serum antibodies against SARS-CoV□2 in healthcare workers who participated in the operation of charter flights for the evacuation of Japanese residents from Hubei Province Open
Summary There are several recommendations for the use of personal protective equipment (PPE) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the selection of appropriate PPE for the current situatio…
View article: A novel highly quantitative and reproducible assay for the detection of anti-SARS-CoV-2 IgG and IgM antibodies
A novel highly quantitative and reproducible assay for the detection of anti-SARS-CoV-2 IgG and IgM antibodies Open
The quantitative range and reproducibility of current serological tests for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are not optimized. Herein, we developed a diagnostic test that detects SARS-CoV-2 IgG and IgM with hig…
View article: Positive Ratio of Polymerase Chain Reaction (PCR) and Validity of Pre-Screening Criteria at an Outpatient Screening Center during the Early Phase of the COVID-19 Epidemic in Japan
Positive Ratio of Polymerase Chain Reaction (PCR) and Validity of Pre-Screening Criteria at an Outpatient Screening Center during the Early Phase of the COVID-19 Epidemic in Japan Open
Despite the increase in COVID-19 cases globally, the number of cases in Japan has been relatively low, and an explosive surge in the prevalence has not occurred. In March 2020, the Ministry of Health, Labour and Welfare (MHLW) in Japan rec…
View article: Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan
Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan Open
Abstract An expanded myeloid cell compartment is a hallmark of severe coronavirus disease 2019 (COVID-19). However, data regarding myeloid cell expansion have been collected in Europe, where the mortality rate by COVID-19 is greater than t…
View article: Epstein-Barr virus induced skin rash in infectious mononucleosis
Epstein-Barr virus induced skin rash in infectious mononucleosis Open
•Epstein-Barr virus (EBV) causes infectious mononucleosis (IM) with skin rash.•EBV skin rash in IM is known to appear after exposure to antimicrobials.•However, skin rash sometimes occur even in the absence of antimicrobial exposure.•Clini…
View article: Extracorporeal membrane oxygenation may decrease the plasma concentration of remdesivir in a patient with severe coronavirus disease 2019
Extracorporeal membrane oxygenation may decrease the plasma concentration of remdesivir in a patient with severe coronavirus disease 2019 Open