Yuting Pan
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View article: tRF‐30‐FP18LPMBQ4NK in Systemic Juvenile Idiopathic Arthritis: A Promising Diagnostic and Disease Activity Biomarker
tRF‐30‐FP18LPMBQ4NK in Systemic Juvenile Idiopathic Arthritis: A Promising Diagnostic and Disease Activity Biomarker Open
Diagnosing systemic juvenile idiopathic arthritis (sJIA) poses significant challenges. Accumulating evidence has indicated that tRNA‐derived fragments (tRFs) play integral roles in the pathogenesis of numerous diseases. Plasma samples were…
View article: Highly efficient and selective CO2/H2 separation by graphene adsorbent with amine modification
Highly efficient and selective CO2/H2 separation by graphene adsorbent with amine modification Open
View article: Increased ferritin, serum lactate dehydrogenase, and aspartate aminotransferase levels predict macrophage activation syndrome complicating systemic lupus erythematosus: a retrospective study
Increased ferritin, serum lactate dehydrogenase, and aspartate aminotransferase levels predict macrophage activation syndrome complicating systemic lupus erythematosus: a retrospective study Open
Background This study aimed to assess the diagnosis of macrophage activation syndrome (MAS) at the onset of active childhood-onset systemic lupus erythematosus (cSLE), which is under-researched, and to compare the characteristics of cSLE w…
View article: The active ingredient β-sitosterol in Ganoderma regulates CHRM2-mediated aerobic glycolysis to induce apoptosis of lung adenocarcinoma cells
The active ingredient β-sitosterol in Ganoderma regulates CHRM2-mediated aerobic glycolysis to induce apoptosis of lung adenocarcinoma cells Open
β-sitosterol is a natural plant steroidal compound with anti-cancer properties against various tumors. This work explored the inhibitory effect of β-sitosterol on the progression of lung adenocarcinoma (LUAD) and further analyzed its targe…
View article: Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia
Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia Open
For cystic fibrosis patients, a lung-targeted gene therapy would significantly alleviate pulmonary complications associated with morbidity and mortality. However, mucus in the airways and cell entry pose huge delivery barriers for local ge…
View article: Phospho-code of a conserved transcriptional factor underpins fungal virulence
Phospho-code of a conserved transcriptional factor underpins fungal virulence Open
These findings provide a novel insight into the regulatory mechanism of CgMkk1-CgCrzA-CgChs5/6, which enables response of the cell wall inhibitor CFW and facilitates infectious growth for C. gloeosporioides.
View article: Trisomy 8 presentation by inflammatory manifestations and its response to thalidomide: two case reports and narrative review
Trisomy 8 presentation by inflammatory manifestations and its response to thalidomide: two case reports and narrative review Open
Objective It has been recognized that there is a nexus among Trisomy 8 (T8), Behcet's disease (BD), and myelodysplastic syndrome (MDS). We reported a series of inflammatory features in 2 children with T8 without hematological involvement. …
View article: Correction: Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune score (mGRIm-s) as a clinico-immunological tool
Correction: Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune score (mGRIm-s) as a clinico-immunological tool Open
View article: Involvement of the Transporter CgTrk1 in Potassium Uptake, Invasive Growth, and Full Virulence in Colletotrichum gloeosporioides
Involvement of the Transporter CgTrk1 in Potassium Uptake, Invasive Growth, and Full Virulence in Colletotrichum gloeosporioides Open
Colletotrichum gloeosporioides is one of the more economically important pathogen causing anthracnose on crops and trees worldwide. As an essential mineral nutrient, potassium play a vital role for fundamental cellular processes in organis…
View article: Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune Score (mGRIm-s) as a clinico-immunological tool
Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune Score (mGRIm-s) as a clinico-immunological tool Open
View article: Efficacy and safety of canakinumab in systemic juvenile idiopathic arthritis, the first Chinese experience
Efficacy and safety of canakinumab in systemic juvenile idiopathic arthritis, the first Chinese experience Open
Background Systemic juvenile idiopathic arthritis (sJIA) is a severe form of juvenile arthritis that is characterized by chronic joint inflammation and systemic symptoms such as fever, rash, and organ involvement. Anti-IL-6 receptor monocl…
View article: Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy
Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy Open
View article: A retrospective study of infantile-onset Takayasu arteritis: experience from a tertiary referral center in China
A retrospective study of infantile-onset Takayasu arteritis: experience from a tertiary referral center in China Open
Objective Takayasu artery (TAK) is a chronic inflammatory disease that mainly affects the aorta and its major branches and is rarely reported in infants. We aimed to summarize the clinical features of infant TA (I-TA) in a tertiary care ce…
View article: Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies
Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies Open
Tumor extracellular matrix (ECM) forms a net negative charged network that interacts with and hinders the transport of molecules partly based on electrostatic interactions. The focus on drug delivery in solid tumors has traditionally been …
View article: 2,4‐Dihydroxybenzoic Acid, a Novel SA Derivative, Controls Plant Immunity via UGT95B17‐Mediated Glucosylation: A Case Study in <i>Camellia Sinensis</i>
2,4‐Dihydroxybenzoic Acid, a Novel SA Derivative, Controls Plant Immunity via UGT95B17‐Mediated Glucosylation: A Case Study in <i>Camellia Sinensis</i> Open
The plant hormone salicylic acid (SA) plays critical roles in plant innate immunity. Several SA derivatives and associated modification are identified, whereas the range and modes of action of SA‐related metabolites remain elusive. Here, t…
View article: Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia
Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia Open
For cystic fibrosis (CF) patients, a lung targeted gene therapy would significantly alleviate pulmonary complications associated with morbidity and mortality. However, mucus in the airways and cell entry pose huge delivery barriers for loc…
View article: tRF-21-LNK8KEP1B as a potential novel diagnostic biomarker for enthesitis-related arthritis
tRF-21-LNK8KEP1B as a potential novel diagnostic biomarker for enthesitis-related arthritis Open
Collectively, we demonstrated the promising role of serum tRF-21-LNK8KEP1B -levels as a diagnostic biomarker for ERA.
View article: Molecular mechanism of lycopene cyclases regulating carotenoids ratio in different branches during tea leaf and flower development
Molecular mechanism of lycopene cyclases regulating carotenoids ratio in different branches during tea leaf and flower development Open
Carotenoids are essential components in tea quality, contributing to leaf color and aroma. However, little information about carotenoids in different tea cultivars and their biosynthesis regulation mechanism during leaf development is know…
View article: Novel Predictive Scoring System for Intravenous Immunoglobulin Resistance Helps Timely Intervention in Kawasaki Disease: The Chinese Experience
Novel Predictive Scoring System for Intravenous Immunoglobulin Resistance Helps Timely Intervention in Kawasaki Disease: The Chinese Experience Open
Background. Approximately 10%–20% of patients with Kawasaki disease (KD) are nonresponsive to intravenous immunoglobulin (IVIG) treatment, placing them at higher risk of developing coronary heart lesions. Early detection of nonresponsivene…
View article: Volatile compound-mediated plant–plant interactions under stress with the tea plant as a model
Volatile compound-mediated plant–plant interactions under stress with the tea plant as a model Open
Plants respond to environmental stimuli via the release of volatile organic compounds (VOCs), and neighboring plants constantly monitor and respond to these VOCs with great sensitivity and discrimination. This sensing can trigger increased…
View article: Online News Media Analysis on Information Management of “G20 Summit” Based on Social Network Analysis
Online News Media Analysis on Information Management of “G20 Summit” Based on Social Network Analysis Open
This paper contributes to the Special Issue on Communication for the Digital Media Age by investigating the factors that influence the management of political information on online news media platforms, specifically Twitter and Weibo. Usin…
View article: Effectiveness of tumor necrosis factor inhibitors in children with enthesitis-related arthritis: a single-center retrospective analysis
Effectiveness of tumor necrosis factor inhibitors in children with enthesitis-related arthritis: a single-center retrospective analysis Open
Objective In children with enthesitis-related arthritis (ERA), the hip and sacroiliac joint function might be impaired if not properly treated. We sought to evaluate the effectiveness of anti-tumor necrosis factor-α (TNF-α) therapy using t…
View article: Novel predictive scoring system for intravenous immunoglobulin resistance helps timely intervention in Kawasaki disease: the Chinese experience
Novel predictive scoring system for intravenous immunoglobulin resistance helps timely intervention in Kawasaki disease: the Chinese experience Open
Background: Approximately 10–20% of patients with Kawasaki disease (KD) are non-responsive to intravenous immunoglobulin treatment, placing them at higher risk of developing coronary heart lesions. Early detection of non-responsiveness is …
View article: Axial involvement in enthesitis-related arthritis: results from a single-center cohort
Axial involvement in enthesitis-related arthritis: results from a single-center cohort Open
Background Axial involvement in children with enthesitis-related arthritis (ERA) has characteristics that differ from those of peripheral involvement. This study characterized their clinical characteristics and treatment. Methods Patients …
View article: Axial Involvement in Enthesitis-Related Arthritis: Results from a Single-Center Cohort
Axial Involvement in Enthesitis-Related Arthritis: Results from a Single-Center Cohort Open
Background: Axial involvement in children with enthesitis-related arthritis (ERA) has characteristics that differ from those of peripheral involvement. This study characterized their clinical characteristics and treatment. Methods: Patient…
View article: Tideglusib Inhibits Pif1 Helicase of <i>Bacteroides</i> sp. via an Irreversible and Cys-380-Dependent Mechanism
Tideglusib Inhibits Pif1 Helicase of <i>Bacteroides</i> sp. via an Irreversible and Cys-380-Dependent Mechanism Open
Pif1 helicase plays multiple roles in maintaining genome stability, which is an attractive therapeutic target for helicase-related diseases, while small molecules targeting Pif1 are not yet available. In this study, we performed a fluoresc…
View article: Promoter and coding sequence diversity of CsCCD1 may contribute to the differential accumulation of floral β-ionone in fresh tea leaves
Promoter and coding sequence diversity of CsCCD1 may contribute to the differential accumulation of floral β-ionone in fresh tea leaves Open
The carotenoid-derived volatile β-ionone makes an important contribution to tea fragrance. Here, we qualitatively and quantitatively analysed 15 carotenoids in tea leaves of 13 cultivars by UHPLC-APCI-MS/MS. The 13 cultivars were divided i…
View article: The aging behavior of biochar and its immobilizing ability to heavy metals in the rhizosphere
The aging behavior of biochar and its immobilizing ability to heavy metals in the rhizosphere Open
The application effect of biochar in soil is often affected by environmental factors, but the effect of rhizosphere processes on the properties and functions of biochar remains unclear. The purpose of this study was to explore the effect o…
View article: Involvement of Protein Kinase CgSat4 in Potassium Uptake, Cation Tolerance, and Full Virulence in Colletotrichum gloeosporioides
Involvement of Protein Kinase CgSat4 in Potassium Uptake, Cation Tolerance, and Full Virulence in Colletotrichum gloeosporioides Open
The ascomycete Colletotrichum gloeosporioides is a causal agent of anthracnose on crops and trees and causes enormous economic losses in the world. Protein kinases have been implicated in the regulation of growth and development, and respo…
View article: Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2
Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2 Open
Wnt/β-catenin signaling is a well-established driver of colon cancer; however, a targeted therapeutic agent has not reached clinics yet. In the present study, we report that the natural compound liquidambaric acid (LDA) inhibits oncogenic …