Yuto Sumida
YOU?
Author Swipe
View article: Discovery and development of an oral analgesic targeting the α2B adrenoceptor
Discovery and development of an oral analgesic targeting the α2B adrenoceptor Open
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonists such as clonidine and dexmedetomidine exhibit analgesic and opioid-sparing effects. Howev…
View article: Organic photoredox-catalyzed unimolecular PCET of benzylic alcohols
Organic photoredox-catalyzed unimolecular PCET of benzylic alcohols Open
Proton-coupled electron transfer (PCET) is a crucial chemical process involving the simultaneous or sequential transfer of protons and electrons, playing a vital role in biological processes and energy conversion technologies.
View article: Endoplasmic reticulum transporter OAT2 regulates drug metabolism and interaction
Endoplasmic reticulum transporter OAT2 regulates drug metabolism and interaction Open
Xenobiotic metabolic reactions in the hepatocyte endoplasmic reticulum (ER) including UDP-glucuronosyltransferase and carboxylesterase play central roles in the detoxification of medical agents with small- and medium-sized molecules. Altho…
View article: Radical Chemistry of Photoexcitable Borates
Radical Chemistry of Photoexcitable Borates Open
Chemical reactions based on photoexcitation of molecules allow unusual modes that are not available via thermal pathways. Recent photoredox catalysis enable generation of carbon-centered radicals under mild conditions, which previously req…
View article: Diastereoselective congested β-amido ketone synthesis via NHC-catalyzed radical–radical coupling
Diastereoselective congested β-amido ketone synthesis via NHC-catalyzed radical–radical coupling Open
N-Heterocyclic carbene catalysis merging with photoredox PCET enabled amidoacylation of alkenes to construct sterically congested cyclic β-amido ketone skeleton bearing α-tertiary or quaternary carbon centers with high diastereoselectivity…
View article: meta-Selective Radical Acylation of Electron-rich Arenes
meta-Selective Radical Acylation of Electron-rich Arenes Open
meta-Selective functionalisation of electron-rich arenes provides a non-traditional route to organic synthesis. In classical electrophilic aromatic substitution of electron-donating group-pendant arenes, functionalisation occurs according …
View article: CCDC 2217403: Experimental Crystal Structure Determination
CCDC 2217403: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2217405: Experimental Crystal Structure Determination
CCDC 2217405: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2217404: Experimental Crystal Structure Determination
CCDC 2217404: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: meta-Selective Radical Acylation of Electron-rich Arenes
meta-Selective Radical Acylation of Electron-rich Arenes Open
meta-Selective functionalisation of electron-rich arenes provides a non-traditional route to organic synthesis. In classical electrophilic aromatic substitution of electron-donating group-pendant arenes, functionalisation occurs according …
View article: Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate
Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate Open
Native Oplophorus luciferase (OpLase) and its catalytic 19 kDa protein (wild KAZ) show highest luminescence activity with coelenterazine (CTZ) among CTZ analogs. Mutated wild KAZ with 16 amino acid substitutions (nanoKAZ/nanoLuc) utilizes …
View article: CCDC 2163500: Experimental Crystal Structure Determination
CCDC 2163500: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2114101: Experimental Crystal Structure Determination
CCDC 2114101: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A
Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A Open
View article: CCDC 2034958: Experimental Crystal Structure Determination
CCDC 2034958: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2034956: Experimental Crystal Structure Determination
CCDC 2034956: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2080640: Experimental Crystal Structure Determination
CCDC 2080640: Experimental Crystal Structure Determination Open
View article: CCDC 2080643: Experimental Crystal Structure Determination
CCDC 2080643: Experimental Crystal Structure Determination Open
View article: CCDC 2080645: Experimental Crystal Structure Determination
CCDC 2080645: Experimental Crystal Structure Determination Open
View article: Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin
Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin Open
The Ca 2+ -binding photoprotein aequorin is a complex of apoAequorin (apoprotein) and ( S )-2-peroxycoelenterazine. Aequorin can be regenerated by the incubation of apoAequorin with coelenterazine and molecular oxygen (O 2 ). In this study…
View article: Fluorescent-Oxaboroles: Synthesis and Optical Property by Sugar Recognition
Fluorescent-Oxaboroles: Synthesis and Optical Property by Sugar Recognition Open
The optical property of fluorescent unit-conjugated aliphatic oxaboroles has been investigated. The oxaboroles provide good fluorescence quantum yields and selective recognition toward D-ribose and D-ribose containing molecules. The molecu…
View article: CCDC 2003738: Experimental Crystal Structure Determination
CCDC 2003738: Experimental Crystal Structure Determination Open
View article: Hydrosilyl Group-directed Iridium-catalyzed <i>peri</i>-Selective C–H Borylation of Ring-fused (Hetero)Arenes
Hydrosilyl Group-directed Iridium-catalyzed <i>peri</i>-Selective C–H Borylation of Ring-fused (Hetero)Arenes Open
The iridium-catalyzed direct C–H borylation of ring-fused (hetero)arenes afforded borylated products in a peri-selective manner, directed by a proximal hydrosilyl group. Further selective transformations of the boryl and silyl groups enabl…
View article: CCDC 1850636: Experimental Crystal Structure Determination
CCDC 1850636: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1850633: Experimental Crystal Structure Determination
CCDC 1850633: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice
Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice Open
Significance Since Down syndrome (DS) is caused by trisomy of chromosome 21, prenatal diagnosis of DS is now possible. Nonetheless, parents of a fetus diagnosed with DS have only two choices: terminate the pregnancy or prepare to raise a c…
View article: CCDC 1557998: Experimental Crystal Structure Determination
CCDC 1557998: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Selective inhibition of the kinase DYRK1A by targeting its folding process
Selective inhibition of the kinase DYRK1A by targeting its folding process Open
View article: Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ
Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ Open
View article: An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether
An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether Open
An alternative method for generating arynes from ortho-silylaryl triflates using cesium carbonate and 18-crown-6 is reported. The method was efficiently applied to a variety of reactions between several arynes and arynophiles. We also demo…