Explanipedia

Sensitivity evaluation to EZH2 inhibitors and EZH2 functional analysis in endometrial cancer cell lines Open

Takafumi Onishi, Hiroshi Niimi, Aya Kumazaki, Y. MASAKI, Shogo Nomura , et al. · 2025

The incidence of endometrial cancer (EC) is increasing globally, highlighting the need for novel therapies targeting molecular drivers of malignancy. The enhancer of zeste homolog 2 (EZH2), a histone methyltransferase implicated in tumor p…

Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo Open

Masahito Noguchi, Aya Miyauchi, Y. MASAKI, Masashi Sakaki, Xiao‐Feng Lei , et al. · 2024

This study investigated the role of Hic-5 in liver fibrosis and steatohepatitis, highlighting its potential as a therapeutic target. We developed an antisense oligonucleotide (ASO) that was particularly transportable to the liver, and targ…

Snowmass Theory Frontier: Astrophysics and Cosmology Open

Joshua T. Ruderman, Benjamin R. Safdi, Jessie Shelton, Ana Achúcarro, Peter Adshead , et al. · 2022

We summarize progress made in theoretical astrophysics and cosmology over the past decade and areas of interest for the coming decade. This Report is prepared as the TF09 "Astrophysics and Cosmology" topical group summary for the Theory Fr…

Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides Open

Y. MASAKI, Yukiko Onishi, Kohji Seio · 2022

Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface Open

Hidenori Okamura, Giang Hoang Trinh, Zhuoxin Dong, Y. MASAKI, Kohji Seio , et al. · 2022

Unnatural base pairs (UBPs) which exhibit a selectivity against pairing with canonical nucleobases provide a powerful tool for the development of nucleic acid-based technologies. As an alternative strategy to the conventional UBP designs, …

Leptoflavorgenesis: baryon asymmetry of the Universe from lepton flavor violation Open

Kyohei Mukaida, Kai Schmitz, Y. MASAKI · 2021

Charged-lepton flavor violation (CLFV) is a smoking-gun signature of physics beyond the Standard Model. The discovery of CLFV in upcoming experiments would indicate that CLFV processes must have been efficient in the early Universe at rela…

Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping Open

Yuko Hara–Azumi, Yoshitaka Mizobe, Yukiko Inoue, Yasumasa Hashimoto, Norio Motohashi , et al. · 2020

Duchenne muscular dystrophy (DMD) is a fatal X-linked disorder caused by nonsense or frameshift mutations in the DMD gene. Among various treatments available for DMD, antisense oligonucleotides (ASOs) mediated exon skipping is a promising …

Synthesis of Fluorescent Nucleic Acids bearing Nucleobases Modified with Heteroaryl Group and Fluorophores Open

Kohji Seio, Takashi Kanamori, Y. MASAKI · 2018

In recent years, fluorescent nucleobase analogs have received a great deal of attention due to their unique photophysical properties as well as their potential usefulness as probes for the higher order structures of nucleic acids. One of t…

Application of 2′-<i>O</i>-(2-<i>N</i>-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides Open

Y. MASAKI, Yusuke Iriyama, Hiroyuki Nakajima, Yusuke Kuroda, Tatsuro Kanaki , et al. · 2018

An RNase H-dependent antisense oligonucleotide (ASO), having the 2'-O-(2-N-methylcarbamoylethyl) (MCE) modification, was evaluated in vitro and in vivo. The antisense activities of an ASO having the MCE modification were comparable with th…

Synthesis of photocaged 6-O-(2-nitrobenzyl)guanosine and 4-O-(2-nitrobenzyl) uridine triphosphates for photocontrol of the RNA transcription reaction Open

Kentaro Ohno, Daiki Sugiyama, Leo Takeshita, Takashi Kanamori, Y. MASAKI , et al. · 2017

Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation Open

Takashi Kanamori, Akihiro Takamura, Nobuhiro Tago, Y. MASAKI, Akihiro Ohkubo , et al. · 2017

Green fluorescent protein (GFP)-based molecular-rotor chromophores were attached to the deoxyuridines and incorporated into the oligodeoxynucleotides.

Enzymatic synthesis and reverse transcription of RNAs incorporating 2′-O-carbamoyl uridine triphosphate Open

Y. MASAKI, Hyugo Ito, Yuki Oda, Kazufumi Yamazaki, Nobuhiro Tago , et al. · 2016

Enzymatic synthesis and the reverse transcription of RNAs containing 2′-O-carbamoyl uridine were evaluated.

A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3-Protection of Uridine Derivatives Open

Kohji Seio, Mitsuo Sekine, Nobuhiro Tago, Y. MASAKI, Hiroshi Nagasawa , et al. · 2015

Correction to: A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3-Protection of Uridine DerivativesSynlett 2015; 26(18): 2578-2582DOI: 10.1055/s-0035-1560264

Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs Open

Akihiro Ohkubo, Kenji Yamada, Yu Ito, Kiichi Yoshimura, Koichiro Miyauchi , et al. · 2015

A triplex-forming oligonucleotide (TFO) could be a useful molecular tool for gene therapy and specific gene modification. However, unmodified TFOs have two serious drawbacks: low binding affinities and high sequence-dependencies. In this p…

Enceladus' Hydrothermal Activity: Another Habitable World? Open

康人関根, 岳造渋谷, Frank Postberg, Sean Hsu, 勝彦鈴木 , et al. · 2015

会議情報: 国際アストロバイオロジーワークショップ2013（第6回日本アストロバイオロジーネットワーク年次研究会）（2013年11月28日-30日. 宇宙航空研究開発機構宇宙科学研究所（JAXA)（ISAS)）, 相模原市, 神奈川県

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