Yifan Kong
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View article: The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1
The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1 Open
Polo-like kinase 1 (PLK1), a critical cell cycle regulator, is associated with cancer progression and negatively correlates with patient survival in cutaneous melanoma based on clinical database analysis. In a melanoma mouse model induced …
View article: Application of the “five-plane method” for the prenatal diagnosis of fetal extrahepatic portosystemic shunts: a retrospective cohort pilot study
Application of the “five-plane method” for the prenatal diagnosis of fetal extrahepatic portosystemic shunts: a retrospective cohort pilot study Open
The five-plane method can be used to identify the origins of abnormal extrahepatic shunting vessels, and assess the development of the IHPVS before birth. This may aid in genetic counseling and in predicting the prognosis of affected fetus…
View article: Echocardiographic characteristics of 14 cases with uncommon manifestation of Ebstein anomaly in the fetus: a case series report
Echocardiographic characteristics of 14 cases with uncommon manifestation of Ebstein anomaly in the fetus: a case series report Open
The ultrasonic characteristics summarized here enable the accurate prenatal diagnosis of uncommon manifestation of EA. Isolated posterior leaflet displacement may evolve with other morphological anomalies, necessitating regular monitoring.
View article: Research on the Consumption Promotion Effect of Individual Income Tax Special Additional Deductions under the Goal of Common Prosperity
Research on the Consumption Promotion Effect of Individual Income Tax Special Additional Deductions under the Goal of Common Prosperity Open
The report of the 20th National Congress of the Communist Party of China clearly stated that "common prosperity requires enhancing the role of domestic demand as a driving force." Among these measures, the special additional deduction for …
View article: KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer Open
KRAS mutations frequently co-occur with alterations in STK11/LKB1 and/or KEAP1, defining an aggressive subset of lung cancers resistant to immuno- and chemotherapy. While LKB1 loss is associated with vulnerability to DNA damage response-ba…
View article: Sustainability Meets Strategy: Reaching the Environmentally Aware Consumer in the Fashion Industry
Sustainability Meets Strategy: Reaching the Environmentally Aware Consumer in the Fashion Industry Open
This study investigates how perceived green product attributes and corporate environmental responsibility influence eco-conscious consumer attitudes, purchase intentions, and customer loyalty, using Uniqlo Malaysia as the research context.…
View article: Multifunctional tumor vaccines carrying thalidomide regulate T cell exhaustion and ferroptosis for immunotherapy strategies
Multifunctional tumor vaccines carrying thalidomide regulate T cell exhaustion and ferroptosis for immunotherapy strategies Open
Significant advancements have been made in the development of therapeutic tumor vaccines for hepatocellular carcinoma (HCC) in the past decade. However, the application of this technique is restricted by the paucity of suitable vaccine adj…
View article: Artesunate enhances the efficacy of enzalutamide in advanced prostate cancer
Artesunate enhances the efficacy of enzalutamide in advanced prostate cancer Open
Prostate cancer (PCa) is one of the leading causes of death among men worldwide. Treatments targeting the androgen receptor pathway remain the standard therapy for PCa patients. Enzalutamide (ENZ), a second-generation androgen receptor inh…
View article: The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer Open
Enzalutamide, a second-generation androgen receptor inhibitor (also known as an antiandrogen), is used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Tumors often acquire resistance to enzalutamide. Tumor pr…
View article: DNA replication fork speed Acts as a Pacer in Cortical Neurogenesis
DNA replication fork speed Acts as a Pacer in Cortical Neurogenesis Open
DNA replication fork speed, which controls the rate of genome duplication, has emerged as a key regulator of cellular plasticity. However, its role in neurogenesis remains unexplored. Mini-chromosome maintenance complex (MCMs)-binding prot…
View article: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors Open
For patients with advanced non-small-cell lung cancer (NSCLC), dual immune checkpoint blockade (ICB) with CTLA4 inhibitors and PD-1 or PD-L1 inhibitors (hereafter, PD-(L)1 inhibitors) is associated with higher rates of anti-tumour activity…
View article: Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD
Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD Open
PLK1 (Polo-like kinase 1) plays a critical role in the progression of lung adenocarcinoma (LUAD). Recent studies have unveiled that targeting PLK1 improves the efficacy of immunotherapy, highlighting its important role in the regulation of…
View article: Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression
Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression Open
Summary Hexavalent chromium (Cr(VI)) is a class I environmental carcinogen known to induce lung epithelial cell transformation and promote lung cancer progression through alterations in the cell cycle and cellular energy metabolism. In thi…
View article: Method for lithograghic patterning of sensitive materials
Method for lithograghic patterning of sensitive materials Open
Methods for patterning highly sensitive materials, such as organic materials, organic semiconductors, biomolecular materials, and the like, with photolithographic resolution are disclosed. In some embodiments, a germanium mask (304) is for…
View article: Evaluation of the changes in cardiac morphology of fetuses with congenital heart disease using fetalHQ
Evaluation of the changes in cardiac morphology of fetuses with congenital heart disease using fetalHQ Open
Objective: To evaluate the changes in cardiac morphology of fetuses with congenital heart disease (CHD) using the fetal heart quantitative technique (fetalHQ).Methods: A total of 20 normal pregnant women (control group) and 20 pregnant wom…
View article: Synergistic silver doping and N vacancy promoting photocatalytic performances of carbon nitride for pollutant oxidation and hydrogen production
Synergistic silver doping and N vacancy promoting photocatalytic performances of carbon nitride for pollutant oxidation and hydrogen production Open
Carbon nitride (C3N4) has attracted immense interest as a low-cost, non-toxic and naturally abundant raw material. However, graphite-like phase carbon nitride (g-C3N4) still suffers from poor visible light absorption, fast charge carrier r…
View article: Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling
Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling Open
Metastasis of lung adenocarcinoma (LUAD) is a major cause of death in patients. Aryl hydrocarbon receptor (AHR), an important transcription factor, is involved in the initiation and progression of lung cancer. Polo-like kinase 1 (PLK1), a …
View article: Intrauterine transmission of SARS-CoV-2 to and prenatal ultrasound abnormal findings in the fetus of a pregnant woman with mild COVID-19
Intrauterine transmission of SARS-CoV-2 to and prenatal ultrasound abnormal findings in the fetus of a pregnant woman with mild COVID-19 Open
Background Whether intrauterine transmission of COVID-19 occurs remains uncertain, and it remains unclear whether the disease affects fetuses. We present a case of intrauterine transmission of SARS-CoV-2 infection and the prenatal ultrason…
View article: Single-cell analysis characterizes PLK1 as a catalyst of an immunosuppressive tumor microenvironment in LUAD
Single-cell analysis characterizes PLK1 as a catalyst of an immunosuppressive tumor microenvironment in LUAD Open
PLK1 (Polo-like kinase 1) plays a critical role in the progression of lung adenocarcinoma (LUAD). Recent studies have unveiled that targeting PLK1 improves the efficacy of immunotherapy, highlighting its important role in the regulation of…
View article: Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling
Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling Open
Metastasis of Lung adenocarcinoma (LUAD) is a major cause of death in patients. Aryl hydrocarbon receptor (AHR) is an important transcription factor involved in the initiation and progression of lung cancer. Polo-like kinase 1 (PLK1), a se…
View article: Supplementary Figure 2 from Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer
Supplementary Figure 2 from Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer Open
a negative control to show that synergistic effect does not exist in BRCA wildtype, p53 wildtype cells.
View article: Figure S3 from Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer
Figure S3 from Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer Open
Combination of GSK126 and low-concentration metformin