Yutong Su
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View article: From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS
From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS Open
Chronic neuroinflammation is increasingly recognized not merely as a consequence of CNS pathology but as a driver of glioma initiation. Sustained immune activation, induced by trauma, infection, or neurodegeneration, reshapes the brain’s i…
View article: TLR9 decreases FOXO3 expression to prevent excessive inflammation in macrophage activation syndrome
TLR9 decreases FOXO3 expression to prevent excessive inflammation in macrophage activation syndrome Open
View article: Occult Hypercalcemia Unmasked: Insights From Remitting Seronegative Symmetrical Synovitis With Pitting Edema (RS3PE) Syndrome Associated With a Gastrointestinal Lymphoma
Occult Hypercalcemia Unmasked: Insights From Remitting Seronegative Symmetrical Synovitis With Pitting Edema (RS3PE) Syndrome Associated With a Gastrointestinal Lymphoma Open
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory arthritis that may present as a paraneoplastic syndrome. We report a case of a 51-year-old woman who initially responded to high-dose steroids f…
View article: Immunotherapy for high-grade endometrial stromal sarcoma: a narrative review bridging molecular insights to clinical translation
Immunotherapy for high-grade endometrial stromal sarcoma: a narrative review bridging molecular insights to clinical translation Open
High-grade endometrial stromal sarcoma (HGESS) is a rare solid malignancy characterized by a poor prognosis and highly aggressive behavior. Currently, surgical resection remains the primary treatment for HGESS. Radiotherapy and chemotherap…
View article: Disease association study of Autoimmune and autoinflammatory diseases by integrating multi-modal data and hierarchical ontologies
Disease association study of Autoimmune and autoinflammatory diseases by integrating multi-modal data and hierarchical ontologies Open
Background Autoimmune and autoinflammatory diseases (AIIDs) are characterized by significant heterogeneity and comorbidities, complicating their mechanisms and classification. Disease associations studies, or diseasome, facilitate the expl…
View article: Global Trends and Emerging Frontiers on Ovarian Endometriosis: A Bibliometric and Visualization Analysis
Global Trends and Emerging Frontiers on Ovarian Endometriosis: A Bibliometric and Visualization Analysis Open
In our study, the main directions of ovarian endometriosis include pathogenesis and cancerization. In addition, infertility has received growing attention in recent years. A comprehensive analysis of the publications in this field could he…
View article: Ruxolitinib targets JAK-STAT signaling to modulate neutrophil activation in refractory macrophage activation syndrome
Ruxolitinib targets JAK-STAT signaling to modulate neutrophil activation in refractory macrophage activation syndrome Open
Macrophage activation syndrome (MAS) is believed to be caused by inappropriate proliferation and activation of the mononuclear phagocytic system. Adult-onset Still disease (AOSD) is characterized by neutrophil activation and a cytokine sto…
View article: Risk factors for endometrial polyps to transform into endometrial cancer: insights from a bibliometric analysis
Risk factors for endometrial polyps to transform into endometrial cancer: insights from a bibliometric analysis Open
View article: Uncovering Immune Surveillance Deficiency in B Cell-Driven Autoimmune Disease
Uncovering Immune Surveillance Deficiency in B Cell-Driven Autoimmune Disease Open
Antiphospholipid syndrome (APS) serves as a prototypical disease model for investigating immune tolerance breakdown in systemic autoimmunity of B cell. Single-cell RNA and V(D)J repertoire sequencing on paired bone marrow and peripheral bl…
View article: Deciphering the Impact of Genomic Variation on Clinical Outcomes in Adult-Onset Still's Disease with Macrophage Activation Syndrome
Deciphering the Impact of Genomic Variation on Clinical Outcomes in Adult-Onset Still's Disease with Macrophage Activation Syndrome Open
View article: Correction: Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still’s disease
Correction: Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still’s disease Open
View article: Assessment of the 2023 ACR/EULAR antiphospholipid syndrome classification criteria in a Chinese cohort: Impact on clinical practice
Assessment of the 2023 ACR/EULAR antiphospholipid syndrome classification criteria in a Chinese cohort: Impact on clinical practice Open
The new criteria presented notable advancements in specificity. This study provides detailed insights into the strengths and possible challenges of the 2023 ACR/EULAR criteria, enhancing our understanding of their impact on clinical practi…
View article: Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease Open
Macrophage activation syndrome (MAS) is a potentially fatal consequence of adult-onset Still's disease (AOSD), driven by a cytokine storm. Efficient early diagnosis of AOSD-associated MAS requires a sensitive and specific biomarker. In thi…
View article: Anti‐signal recognition particle antibodies induce cardiac diastolic dysfunction via oxidative stress injury
Anti‐signal recognition particle antibodies induce cardiac diastolic dysfunction via oxidative stress injury Open
Objectives Anti‐signal recognition particle (SRP) antibodies, markers of immune‐mediated necrotising myopathy, are reportedly related to cardiac involvement; however, whether they are pathogenic to the myocardium remains unclear. We aimed,…
View article: Application of precision medicine based on synthetic biology in the prevention and treatment of chronic diseases
Application of precision medicine based on synthetic biology in the prevention and treatment of chronic diseases Open
Chronic non-communicable diseases have long been a significant factor affecting public health. If left unchecked, their protracted course and exorbitant treatment costs can inflict irreversible harm on patients' lives and finances. Chronic…
View article: The use of high-sensitivity cardiac troponin I in assessing cardiac involvement and Disease prognosis in idiopathic inflammatory myopathy
The use of high-sensitivity cardiac troponin I in assessing cardiac involvement and Disease prognosis in idiopathic inflammatory myopathy Open
Objectives Cardiac involvement is one of the most serious complications of idiopathic inflammatory myopathy (IIM) that indicates poor prognosis. However, there is a lack of effective biomarkers for the identification of cardiac involvement…
View article: Biocontrol of bacterial wilt disease in tomato using Bacillus subtilis strain R31
Biocontrol of bacterial wilt disease in tomato using Bacillus subtilis strain R31 Open
Bacterial wilt disease caused by Ralstonia solanacearum is a widespread, severe plant disease. Tomato ( Solanum lycopersicum ), one of the most important vegetable crops worldwide, is particularly susceptible to this disease. Biological co…
View article: Value of the HFA-PEFF diagnostic algorithms for heart failure with preserved ejection fraction to the inflammatory myopathy population
Value of the HFA-PEFF diagnostic algorithms for heart failure with preserved ejection fraction to the inflammatory myopathy population Open
View article: The plant protection preparation GZM improves crop immunity, yield, and quality
The plant protection preparation GZM improves crop immunity, yield, and quality Open
View article: Continuation, reduction, or withdrawal of tofacitinib in patients with rheumatoid arthritis achieving sustained disease control: a multicenter, open-label, randomized controlled trial
Continuation, reduction, or withdrawal of tofacitinib in patients with rheumatoid arthritis achieving sustained disease control: a multicenter, open-label, randomized controlled trial Open
Background: Rheumatoid arthritis (RA), a chronic systemic autoimmune disease, is characterized by synovitis and progressive damage to the bone and cartilage of the joints, leading to disability and reduced quality of life. This study was a…
View article: Differential diagnostic performance of PET/CT in adult-onset still’s disease and lymphoma: a retrospective pilot study
Differential diagnostic performance of PET/CT in adult-onset still’s disease and lymphoma: a retrospective pilot study Open
Our scoring model showed good diagnosis performance in distinguishing AOSD from lymphoma.
View article: Fucosylation of anti-dsDNA IgG1 correlates with disease activity of treatment-naïve systemic lupus erythematosus patients
Fucosylation of anti-dsDNA IgG1 correlates with disease activity of treatment-naïve systemic lupus erythematosus patients Open
This work is supported by the National Key Research and Development Program of China (2018YFC0910303), National Natural Science Foundation of China (81801592, 82101876), Clinical Research Plan of SHDC (SHDC2020CR4011), Ruijin Hospital Yout…
View article: Enhanced type I interferon signature induces neutrophil extracellular traps enriched in mitochondrial DNA in adult-onset Still's disease
Enhanced type I interferon signature induces neutrophil extracellular traps enriched in mitochondrial DNA in adult-onset Still's disease Open
Adult-onset Still's disease (AOSD) is a rare but clinically well-known auto-inflammatory disorder. Cytokine storm, the hallmark of AOSD, is mediated by neutrophil hyperactivation and enhanced neutrophil extracellular trap (NET) formation. …
View article: Building of a standard system for supervision over financial technology enterprises from the perspective of governmental regulation
Building of a standard system for supervision over financial technology enterprises from the perspective of governmental regulation Open
In recent years, financial technology (FinTech) enterprises have thrived in China. However, the flourishing FinTech field is accompanied by the lagging of financial supervision. Regardless of innovations, FinTech is in essence related to t…
View article: Urine Proteomics Differentiate Primary Thrombotic Antiphospholipid Syndrome From Obstetric Antiphospholipid Syndrome
Urine Proteomics Differentiate Primary Thrombotic Antiphospholipid Syndrome From Obstetric Antiphospholipid Syndrome Open
Antiphospholipid syndrome (APS) is a multisystem disorder characterized by thrombosis and/or recurrent fetal loss. This clinical phenotype heterogeneity may result in differences in response to treatment and prognosis. In this study, we ai…
View article: Role of ranulas in early diagnosis of Sjögren’s syndrome: A case report
Role of ranulas in early diagnosis of Sjögren’s syndrome: A case report Open
Our study underlines that ranulas are early clinical signs of SS. As early diagnosis and early intervention of SS are important to obtain better outcomes, our findings underline the need for histopathological test after sublingual adenecto…
View article: Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences
Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences Open
The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s disease (AOSD) is an autoinflammatory disease characterized by life-threatening complications. Systemic hyperinflammation…
View article: A New Predictive Scoring Model for Differential Diagnosis of Adult-Onset Still's Disease and Lymphoma in Patients with FUO: A Cross-Sectional Pilot Study
A New Predictive Scoring Model for Differential Diagnosis of Adult-Onset Still's Disease and Lymphoma in Patients with FUO: A Cross-Sectional Pilot Study Open
View article: A Cohort Study of Liver Involvement in Patients With Adult-Onset Still's Disease: Prevalence, Characteristics and Impact on Prognosis
A Cohort Study of Liver Involvement in Patients With Adult-Onset Still's Disease: Prevalence, Characteristics and Impact on Prognosis Open
Objective: Adult-onset Still's disease (AOSD) is a systemic disorder commonly accompanied by liver involvement. This study aims to illustrate the detailed information of liver abnormalities in patients with AOSD and evaluate the impact on …
View article: Pregnancy Outcomes in Patients With Adult-Onset Still's Disease: A Cohort Study From China
Pregnancy Outcomes in Patients With Adult-Onset Still's Disease: A Cohort Study From China Open
Objective: Adult-onset Still's disease (AOSD) is an autoinflammatory disease with a higher prevalence rate in young females. The purpose of this study is to investigate whether AOSD has an adverse impact on pregnancy outcomes, or conversel…