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View article: Symmetrical Flow Optimization: Reciprocal Lane Reconfiguration and Signal Coordination for Construction Zone Intersections
Symmetrical Flow Optimization: Reciprocal Lane Reconfiguration and Signal Coordination for Construction Zone Intersections Open
In construction work at urban intersections, construction barriers can severely obstruct the view of right-turning vehicles, thereby posing safety hazards and increasing delays. Taking the intersection of Nanhu Avenue and Dongling South St…
View article: <i>p75NTR</i> Promotes Circadian‐Driven Mineralization During Tooth Development via <scp>CK2</scp> / <scp>PER2</scp> Pathway
<i>p75NTR</i> Promotes Circadian‐Driven Mineralization During Tooth Development via <span>CK2</span> / <span>PER2</span> Pathway Open
Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles. However, its regulatory mechanisms in tooth development remain incompletely understood. Here, we investiga…
View article: Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance
Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance Open
Bacillus Calmette‐Guérin (BCG) immunotherapy is limited by resistance in ∼50% of patients, linked to tumor microenvironment (TME) angiogenesis. The work explored if BCG‐activated tumor‐associated macrophages (TAMs) drive angiogenesis via h…
View article: Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation
Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation Open
Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, and its multi-mechanism pathology makes single-target therapy insufficient. Valproic acid (VPA) and alpha-lipoic acid (ALA) are known neuroprotective a…
View article: Development of Nanobody-Based Sandwich ELISA Resistant to SpA Interference for Sensitive Detection of Staphylococcal Enterotoxin A
Development of Nanobody-Based Sandwich ELISA Resistant to SpA Interference for Sensitive Detection of Staphylococcal Enterotoxin A Open
Staphylococcus aureus is a major pathogen responsible for staphylococcal food poisoning (SFP), with its pathogenicity primarily dependent on staphylococcal enterotoxins (SEs). Among these, staphylococcal enterotoxin A (SEA) is a critical r…
View article: Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers
Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers Open
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. Hig…
View article: Construction and application of a mortality risk prediction model for patients with lung squamous cell carcinoma: A competing risk analysis
Construction and application of a mortality risk prediction model for patients with lung squamous cell carcinoma: A competing risk analysis Open
Background: Lung squamous cell carcinoma (LUSC) is the dominant histological subtype of lung cancer, accounting for 30% of all cases. Most patients develop distant metastases by the time they are diagnosed with the disease, owing to a dela…
View article: Emerging opportunities to treat drug-resistant breast cancer: Discovery of novel small-molecule inhibitors against different targets
Emerging opportunities to treat drug-resistant breast cancer: Discovery of novel small-molecule inhibitors against different targets Open
Breast cancer is now the most common malignancy among females. Numerous highly effective small-molecule inhibitors, such as tamoxifen and fulvestrant, have received clinical approval, significantly enhancing the therapeutic landscape of br…
View article: The silent spread: uncovering the diversity and evolution of poxviruses in ticks across Western China’s host landscapes
The silent spread: uncovering the diversity and evolution of poxviruses in ticks across Western China’s host landscapes Open
View article: Clinical and genetic analysis of a case series of 12 Chinese families with hereditary ataxia
Clinical and genetic analysis of a case series of 12 Chinese families with hereditary ataxia Open
Background and objective Hereditary ataxia (HA) encompasses a diverse group of neurological disorders characterized by significant clinical and genetic heterogeneity. This case series study aims to present a case series of HA from Southwes…
View article: Role of fructose in renal cell carcinoma progression
Role of fructose in renal cell carcinoma progression Open
Renal cell carcinoma (RCC) is a highly malignant tumor with a poor prognosis, underscoring the urgent need for novel therapeutic strategies. RCC cells exhibit rapid proliferation and high metabolic demands, leading to hypoglycemic and hypo…
View article: Comparative efficacy of teriparatide and bisphosphonates or denosumab vs. teriparatide monotherapy in osteoporosis: a meta-analysis
Comparative efficacy of teriparatide and bisphosphonates or denosumab vs. teriparatide monotherapy in osteoporosis: a meta-analysis Open
Introduction Teriparatide (TPTD), a widely used bone-promoting drug in osteoporosis (OP) treatment, may cause compensatory bone resorption with long-term monotherapy (>6 months). Combining TPTD with anti-bone resorption drugs (e.g., bis…
View article: Hsa_circ_0072088 promotes non-small cell lung cancer progression through modulating miR-1270/TOP2A axis
Hsa_circ_0072088 promotes non-small cell lung cancer progression through modulating miR-1270/TOP2A axis Open
View article: A novel mouse model of diverse tumors derived from epithelial cells
A novel mouse model of diverse tumors derived from epithelial cells Open
A deeper understanding of pathophysiology, from the initiation of tumors of epithelial cells to the outcomes associated with it, is imperative to test potential interventions for these diseases. However, few models can accomplish this beca…
View article: Effect of different concentrations of heparin-locking solution for central venous catheters in hemodialysis patients: A systematic review and meta-analysis
Effect of different concentrations of heparin-locking solution for central venous catheters in hemodialysis patients: A systematic review and meta-analysis Open
Background The effect of different concentrations of heparin-locking solution for central venous catheters (CVC) in hemodialysis patients is varied. Regarding the optimal concentration of heparin-locking solution, there is no definitive co…
View article: Predicting Depression in Screening Interviews from Interactive Multi-Theme Collaboration
Predicting Depression in Screening Interviews from Interactive Multi-Theme Collaboration Open
Automatic depression detection provides cues for early clinical intervention by clinicians. Clinical interviews for depression detection involve dialogues centered around multiple themes. Existing studies primarily design end-to-end neural…
View article: Investigation of gut microbiota in pediatric patients with peanut allergy in outpatient settings
Investigation of gut microbiota in pediatric patients with peanut allergy in outpatient settings Open
Objective Investigate the diversity of the gut microbiota in children with peanut allergies and assess its association with allergic reactions. Identify potential gut microbial biomarkers for the diagnosis and treatment of peanut allergies…
View article: ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation
ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation Open
View article: Impact of gut microbial diversity on egg production performance in chickens
Impact of gut microbial diversity on egg production performance in chickens Open
Chickens are one of the most economically important poultry species, and their egg-laying performance is a crucial economic trait. The intestinal microbiome plays a significant role in the egg-laying performance. To clarify the diversity o…
View article: Echoes in the Deep: Revealing Influenza A Viruses’ Persistence and Microbial Associations in Aquatic Ecosystems
Echoes in the Deep: Revealing Influenza A Viruses’ Persistence and Microbial Associations in Aquatic Ecosystems Open
Background Influenza A viruses (IAVs) are significant pathogens with complex transmission dynamics in aquatic ecosystems, yet their persistence, evolutionary relationships, and associations with environmental microorganisms remain poorly u…
View article: Epigenetic crosstalk between stem cells and tumors: mechanisms and emerging perspectives
Epigenetic crosstalk between stem cells and tumors: mechanisms and emerging perspectives Open
Stem cells possess self-renewal and multipotent differentiation capabilities, exhibiting broad applications in regenerative medicine and tissue homeostasis maintenance. Their fate regulation relies heavily on precise epigenetic mechanisms.…
View article: eEF2K alleviates doxorubicin-induced cardiotoxicity by inhibiting GSK3β and improving autophagy dysfunction
eEF2K alleviates doxorubicin-induced cardiotoxicity by inhibiting GSK3β and improving autophagy dysfunction Open
View article: The complete chloroplast genome of <i>Lilium paradoxum</i> Stearn (Liliaceae) from southwestern China
The complete chloroplast genome of <i>Lilium paradoxum</i> Stearn (Liliaceae) from southwestern China Open
Lilium paradoxum, a herb from southeastern Xizang, China, has its first complete chloroplast genome sequenced using next-generation sequencing. The genome is 151,814 bp, consisting of inverted repeats (IRs; 26,323 bp), small single-…
View article: Author response: CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells
Author response: CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells Open
View article: Ultra-rapid detection of nuclear protein of severe fever with thrombocytopenia syndrome virus by colloidal gold immunochromatography assay
Ultra-rapid detection of nuclear protein of severe fever with thrombocytopenia syndrome virus by colloidal gold immunochromatography assay Open
In 2009, severe fever with thrombocytopenia syndrome virus (SFTSV), also known as the Dabie bandavirus (DBV), was first discovered in Henan, China. It is a tick-borne zoonotic virus with a fatality rate ranging from 6% to 30%. Currently, w…
View article: Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells
Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells Open
Lactate dehydrogenase (LDH) stands at the intersection of pyruvate metabolism. While it is believed that inhibition of LDH redirects pyruvate to mitochondrial metabolism, suppressing glycolysis and boosting oxidative phosphorylation, the m…
View article: Author response: Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells
Author response: Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells Open
View article: Advancements in a novel model of autophagy and immune network regulation in radioresistance of cancer stem cells
Advancements in a novel model of autophagy and immune network regulation in radioresistance of cancer stem cells Open
Radiotherapy, a precise modality for treating malignant tumors, has undergone rapid advancements in primary and clinical research. The mechanisms underlying tumor radioresistance have become significant research. With the introduction and …
View article: Abnormally High Expression of DNAJB6 Accelerates Malignant Progression of Lung Adenocarcinoma
Abnormally High Expression of DNAJB6 Accelerates Malignant Progression of Lung Adenocarcinoma Open
DNAJB6, a major member of the DNAJ/HSP40 family, plays an important role in tumor development. We explored the effect of DNAJB6 expression on the prognosis of patients and its biological role in lung adenocarcinoma (LUAD). mRNA and clinica…
View article: M6A-methylated circPOLR2B forms an R-loop and regulates the biological behavior of glioma stem cells through positive feedback loops
M6A-methylated circPOLR2B forms an R-loop and regulates the biological behavior of glioma stem cells through positive feedback loops Open