Explanipedia

Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia Open

John Q. Yap, Azadeh Nikouee, Matthew Kim, Quan Cao, David J. Rademacher , et al. · 2025

Males often experience worse cardiac outcomes than females in sepsis. This study identified pyruvate dehydrogenase kinase 4 (PDK4) as a key mediator of this disparity. PDK4 regulates glucose utilization by inhibiting pyruvate dehydrogenase…

The modified heart team protocol facilitated the revascularization decision-making quality in complex coronary artery disease Open

Hanping Ma, Shen Lin, Xi Li, Yang Wang, Weixian Yang , et al. · 2025

OBJECTIVES A lack of standardization in heart team implementation potentially leads to suboptimal decision-making quality, and we previously established a modified heart team protocol to improve the decision-making quality. The present tri…

SP03. Polyamine Metabolism In Mesenchymal Progenitor Cells Modulates Osteogenic Differentiation Open

Chase A. Pagani, Yuxiao Sun, Reid Olson, Sneha Korlakunta, Monisha Mittal , et al. · 2024

The Preliminary Study on Screening and Application of Phthalic Acid-Degrading Bacteria Open

Honghao Zhang, Yang Lin, Rubing Xu, Yuxiao Sun, Yang Yong , et al. · 2024

Phthalic acid is a main pollutant, which is also an important reason for the continuous cropping effect of tobacco. In order to degrade the phthalic acid accumulated in the environment and relieve the obstacle effect of tobacco continuous …

Mesenchymal stem cell-derived extracellular vesicles targeting irradiated intestine exert therapeutic effects Open

Ningning He, Mingxin Dong, Yuxiao Sun, Mengmeng Yang, Yan Wang , et al. · 2024

Background: Radiation-induced intestinal injuries are common in patients with pelvic or abdominal cancer. However, these injuries are currently not managed effectively. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) …

NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway Open

Xiaohui Sun, Mingxin Dong, Jiale Li, Yuxiao Sun, Yu Gao , et al. · 2024

Background: Radiation resistance is the main limitation of the application of radiotherapy. Ionizing radiation (IR) kills cancer cells mainly by causing DNA damage, particularly double-strand breaks (DSBs). Radioresistant cancer cel…

RMI1 facilitates repair of ionizing radiation–induced DNA damage and maintenance of genomic stability Open

Lianying Fang, Yuxiao Sun, Mingxin Dong, Mengmeng Yang, Jianxiu Hao , et al. · 2023

Ionizing radiation (IR) causes a wide variety of DNA lesions, of which DNA double-stranded breaks (DSBs) are the most deleterious. Homologous recombination (HR) is a crucial route responsible for repairing DSBs. RecQ-mediated genome instab…

Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR Open

Yuxiao Sun, Yu Gao, Mingxin Dong, Jiuzhen Li, Xin Li , et al. · 2023

Case report: Multidisciplinary collaboration in diagnosis and treatment of child gaucher disease Open

Jianfang Zhu, Yuxiao Sun, Weiyan Zheng, Chunlin Wang · 2023

Gaucher disease (GD) is an inherited lysosomal storage disease caused by mutations in the glucocerebrosidase gene. The decrease of glucocerebrosidase activity in lysosomes results in the accumulation of its substrate glucocerebroside in th…

Peer Review #1 of "Vibrations on mastoid process alter the gait characteristics during walking on different inclines (v0.1)" Open

Yuxiao Sun, Zhu Dongqi, Huiyan Song, Jung Hung Chien · 2023

Background.: Vestibular dysfunction leads to chronic dizziness, falls, and imbalance, which causes significant impacts on quality of life, even a simple walking from one point to another.Eighty-eight percent of the persons with bilateral v…

Vibrations on mastoid process alter the gait characteristics during walking on different inclines Open

Yuxiao Sun, Zhu Dongqi, Huiyan Song, Jung Hung Chien · 2023

Background Eighty-eight percent of the persons with bilateral vestibular dysfunction have reported at least one fall within the past 5 years. The apparent alternations due to the bilateral vestibular dysfunctions (BVD) are the gait charact…

Age‐Independent Cardiac Protection by Pharmacological Activation of Beclin‐1 During Endotoxemia and Its Association With Energy Metabolic Reprograming in Myocardium—A Targeted Metabolomics Study Open

Matthew Kim, Azadeh Nikouee, Raymond Zou, Di Ren, Zhibin He , et al. · 2022

Background We showed that Beclin‐1‐dependent autophagy protects the heart in young and adult mice that underwent endotoxemia. Herein, we compared the potential therapeutic effects of Beclin‐1 activating peptide, TB‐peptide, on endotoxemia‐…

Genetic Inhibition of Plppr5 Aggravates Hypoxic-Ischemie-Induced Cortical Damage and Excitotoxic Phenotype Open

Yuxiao Sun, Meifang Jin, Lili Li, Yueying Liu, Dandan Wang , et al. · 2022

Hypoxia-ischemia (HI) is the most common acute brain threat in neonates and a leading cause of neurodevelopmental impairment. Exploring the new molecular mechanism of HI brain injury has important clinical translational significance for th…

Evaluation of Parkin in the Regulation of Myocardial Mitochondria-Associated Membranes and Cardiomyopathy During Endotoxemia Open

Matthew Kim, Azadeh Nikouee, Yuxiao Sun, Qing-jun Zhang, Zhiping Liu , et al. · 2022

Background: Mitochondrial deficiency is a known pathology in sepsis-induced organ failure. We previously found that mitochondria-associated membranes (MAMs), a subcellular domain supporting mitochondrial status, are impaired in the heart d…

Preliminary Study of Genome-Wide Association Identified Novel Susceptibility Genes for Hemorheological Indexes in a Chinese Population Open

Yuxiao Sun, Zhaoyun Cheng, Zhiping Guo, Guoyou Dai, Yongqiang Li , et al. · 2022

Background: Genome-wide association studies for various hemorheological characteristics have not been reported. We aimed to identify genetic loci associated with hemorheological indexes in a cohort of healthy Chinese Han indi…

PRG5 Knockout Precipitates Late-Onset Hypersusceptibility to Pilocarpine-Induced Juvenile Seizures by Exacerbating Hippocampal Zinc Signaling-Mediated Mitochondrial Damage Open

Dandan Wang, Meifang Jin, Lili Li, Yueying Liu, Yuxiao Sun , et al. · 2021

Introduction Epileptogenesis is understood as the plastic process that produces a persistent reorganization of the brain’s neural network after a precipitating injury (recurrent neonatal seizures, for instance) with a latent period, finall…

Beclin-1–Dependent Autophagy Improves Outcomes of Pneumonia-Induced Sepsis Open

Azadeh Nikouee, Matthew Kim, Xiangzhong Ding, Yuxiao Sun, Qun S. Zang · 2021

Objective We previously demonstrated that promoting Beclin-1–dependent autophagy is cardiac protective during endotoxemia shock, suggesting that autophagy-based approaches may become a promising therapeutic strategy for sepsis. In this stu…

Proteomics for Studying the Effects of Ketogenic Diet Against Lithium Chloride/Pilocarpine Induced Epilepsy in Rats Open

Yuqin Zheng, Meifang Jin, Guihai Suo, Youjia Wu, Yuxiao Sun , et al. · 2020

The ketogenic diet (KD) demonstrates antiepileptogenic and neuroprotective efficacy, but the precise mechanisms are unclear. Here we explored the mechanism through systematic proteomics analysis of the lithium chloride-pilocarpine rat mode…

Beclin‐1 improves mitochondria‐associated membranes in the heart during endotoxemia Open

Yuxiao Sun, Ying Cai, Suhong Qian, Hellen Chiou, Qun S. Zang · 2020

Mitochondria‐associated membranes (MAMs) are essential to mitochondria. This study was to determine whether endotoxemia rearranges MAMs in the heart, and whether Beclin‐1 regulates this process. Wild‐type mice and mice with a cardiac‐speci…

Study on the Utilization of Inpatient Services for Middle-Aged and Elderly Rural Females in Less Developed Regions of China Open

Xiaotong Wen, Lanyue Cui, Yuan Fang, Xiaojun Liu, Mufeng Ouyang , et al. · 2020

The aim of this study is to understand the utilization of inpatient services and its contributing factors among middle-aged and elderly females (MAEF) in less developed rural regions. Five surveys were conducted between 2006 and 2014 with …

The Initiation of Swallowing Can Indicate the Prognosis of Disorders of Consciousness: A Self-Controlled Study Open

Jianan Wang, Jing Wang, Xiaohua Hu, Lingqi Xu, Jinna Tian , et al. · 2019

Objective: To detect the initiation of swallowing in patients with disorders of consciousness (DOC) as well as the relationship between the initiation of swallowing and the prognosis of DOC patients. Methods: Nineteen DOC pat…

Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources Open

Ningning He, Changyan Xiao, Yuxiao Sun, Yan Wang, Liqing Du , et al. · 2019

Mesenchymal stem cells (MSCs) derived from different tissues may aid in the regeneration of radiation-induced organ lesions; however, the radiation responses of human MSCs from different sources are unknown. In our study, a comparison of t…

Long-Term Effects of Zinc Deficiency and Zinc Supplementation on Developmental Seizure-Induced Brain Damage and the Underlying GPR39/ZnT-3 and MBP Expression in the Hippocampus Open

Chen Nina, Dongjing Zhao, Yuxiao Sun, Dandan Wang, Hong Ni · 2019

We previously illustrated that long-term upregulated expression of ZnT-3 in the hippocampus of rats that underwent neonatal seizures was restored by pretreatment with a ketogenic diet. It was recently demonstrated that upregulated expressi…

Integrated Analysis of the Altered lncRNAs and mRNAs Expression in 293T Cells after Ionizing Radiation Exposure Open

Mengmeng Yang, Yuxiao Sun, Changyan Xiao, Kaihua Ji, Manman Zhang , et al. · 2019

Tissue and cell damage caused by ionizing radiation is often highly genotoxic. The swift repair of DNA damage is crucial for the maintenance of genomic stability and normal cell fitness. Long noncoding RNAs (lncRNAs) have been reported to …

Analysis of Circular RNA Expression Profile in HEK 293T Cells Exposed to Ionizing Radiation Open

Ningning He, Yuxiao Sun, Mengmeng Yang, Qianying Lu, Jinhan Wang , et al. · 2019

Radiation therapy is one of the most common cancer treatments. It is important to understand how cells respond to ionizing radiation (IR) to improve therapeutic efficacy. Circular RNAs (circRNAs) recently have been found to regulate a vari…

Cardiac Autophagy in Sepsis Open

Yuxiao Sun, Ying Cai, Qun S. Zang · 2019

Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and h…

Preliminary quantitative proteomics analysis in chronic and latent Keshan disease by iTRAQ labeling approach Open

Yuxiao Sun, Chuanyu Gao, Xianqing Wang, Yuhao Liu · 2017

Keshan disease is a congestive cardiomyopathy. Dietary selenium deficiency combined with additional stressors are recognized to cause the cardiomyopathies. In this study, clinical condition of individuals with different subtypes including …

Association between <i>PPAP2B</i> gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females Open

Yuxiao Sun, Chuanyu Gao, Lu Yang, Xin Fu, Jun-Ge Jia , et al. · 2017

Little is known about gender-related differences in the association between PPAP2B single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) in Chinese Han males and females. We therefore conducted a case-control study with 4…

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma Open

Dinesh Kumar Singh, Rahul K. Kollipara, Vamsidara Vemireddy, Xiao-Li Yang, Yuxiao Sun , et al. · 2017

Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model Open

Xiao Yao, Deborah Carlson, Yuxiao Sun, Lisha Ma, Steven E. Wolf , et al. · 2015

We have previously shown that mitochondria-targeted vitamin E (Mito-Vit-E), a mtROS specific antioxidant, improves cardiac performance and attenuates inflammation in a pneumonia-related sepsis model. In this study, we applied the same appr…

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