Yuya Ide
YOU?
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View article: MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration
MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration Open
Muscular dystrophy is a group of diseases characterized by progressive weakness and degeneration of skeletal muscles, for which there is currently no cure. Here, we show that microRNA (miR)-33a/b play a crucial role in muscle regeneration.…
View article: 10-Year Trends of Antithrombotic Therapy Status and Clinical Outcomes in Patients With Atrial Fibrillation and Renal Dysfunction ― The Fushimi AF Registry ―
10-Year Trends of Antithrombotic Therapy Status and Clinical Outcomes in Patients With Atrial Fibrillation and Renal Dysfunction ― The Fushimi AF Registry ― Open
Despite the increased use of DOAC in patients with AF since 2011, anticoagulation therapy for AF patients with severe renal dysfunction has largely remained unchanged, and a reduction in adverse events in those patients has not been observ…
View article: Association of left atrial enlargement with heart failure events in non-valvular atrial fibrillation patients with preserved left ventricular ejection fraction
Association of left atrial enlargement with heart failure events in non-valvular atrial fibrillation patients with preserved left ventricular ejection fraction Open
Aims Atrial fibrillation (AF) increases the risk of heart failure (HF); however, little is known regarding the risk stratification for incident HF in AF patients, especially with preserved left ventricular ejection fraction (LVEF). Methods…
View article: KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels
KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels Open
KUS121 ameliorated HF by a mechanism totally different from that of conventional catecholamines. We propose that KUS121 is a promising new option for the treatment of HF.
View article: Proteinuria is independently associated with heart failure events in patients with atrial fibrillation: the Fushimi AF registry
Proteinuria is independently associated with heart failure events in patients with atrial fibrillation: the Fushimi AF registry Open
Aims Previous studies have shown that proteinuria is independently associated with the incidence of atrial fibrillation (AF), and is also associated with the incidence of cardiovascular events such as stroke and thromboembolism in patients…
View article: Differential response to isometric handgrip depending on the heart failure condition in patients with functional mitral regurgitation: a case report
Differential response to isometric handgrip depending on the heart failure condition in patients with functional mitral regurgitation: a case report Open
Background Functional mitral regurgitation (MR) changes dynamically depending on the loading conditions and can cause acute heart failure (HF). Isometric handgrip is a simple stress test and can be performed during early phase of acute HF …
View article: Association of Concomitant Coronary Artery Disease With Cardiovascular Events in Patients With Atrial Fibrillation ― The Fushimi AF Registry ―
Association of Concomitant Coronary Artery Disease With Cardiovascular Events in Patients With Atrial Fibrillation ― The Fushimi AF Registry ― Open
In Japanese AF patients, concomitant CAD was associated with higher prevalences of major co-morbidities and higher incidences of cardiovascular events; however, history of CAD was not associated with the incidence of stroke/SE.
View article: 10-Year Trends of Antithrombotic Therapy Status and Outcomes in Japanese Atrial Fibrillation Patients ― The Fushimi AF Registry ―
10-Year Trends of Antithrombotic Therapy Status and Outcomes in Japanese Atrial Fibrillation Patients ― The Fushimi AF Registry ― Open
Over the past 10 years, there has been a major transition in antithrombotic therapy and a decline in the incidence of adverse events in AF patients.
View article: Isometric Handgrip Stress Test during Right Heart Catheterization in Patients with Mitral Regurgitation -A Case Series Study-
Isometric Handgrip Stress Test during Right Heart Catheterization in Patients with Mitral Regurgitation -A Case Series Study- Open
Objective The severity of mitral regurgitation (MR) dynamically changes during a stress test. Isometric handgrip is a readily-available stress test in daily practice; however, little is known regarding the response to isometric handgrip in…
View article: Clinical Characteristics and Outcomes of Very Elderly Patients With Atrial Fibrillation at High Bleeding Risk ― The Fushimi AF Registry ―
Clinical Characteristics and Outcomes of Very Elderly Patients With Atrial Fibrillation at High Bleeding Risk ― The Fushimi AF Registry ― Open
Background: The ELDERCARE-AF trial demonstrated that low-dose edoxaban prevented stroke or systemic embolism (SE) in very elderly Japanese patients with non-valvular atrial fibrillation (NVAF) in whom standard oral anticoagulant therapy wa…
View article: Identification of Differential Roles of MicroRNA‐33a and ‐33b During Atherosclerosis Progression With Genetically Modified Mice
Identification of Differential Roles of MicroRNA‐33a and ‐33b During Atherosclerosis Progression With Genetically Modified Mice Open
Background Micro RNA (miR)‐33 targets cholesterol transporter ATP ‐binding cassette protein A1 and other antiatherogenic targets and contributes to atherogenic progression. Its inhibition or deletion is known to result in the amelioration …
View article: <i>MiR-33a</i> is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons
<i>MiR-33a</i> is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons Open
Recent reports, including ours, have indicated that microRNA (miR)-33 located within the intron of sterol regulatory element binding protein (SREBP) 2 controls cholesterol homeostasis and can be a potential therapeutic target for the treat…
View article: <i>SREBF1</i>/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo
<i>SREBF1</i>/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo Open
Objective— Atherosclerosis is a common disease caused by a variety of metabolic and inflammatory disturbances. MicroRNA (miR)-33a within SREBF2 (sterol regulatory element-binding factor 2) is a potent target for treatment of atherosclerosi…
View article: Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo
Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo Open
Recent evidence suggests that the accumulation of macrophages as a result of obesity-induced adipose tissue hypoxia is crucial for the regulation of tissue fibrosis, but the molecular mechanisms underlying adipose tissue fibrosis are still…
View article: MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6C<sup>high</sup> Monocytes through Dual Pathways
MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6C<sup>high</sup> Monocytes through Dual Pathways Open
MicroRNA 33 (miR-33) targets ATP-binding cassette transporter A1 (ABCA1), and its deficiency increases serum high-density lipoprotein (HDL)-cholesterol (HDL-C) and ameliorates atherosclerosis. Although we previously reported that miR-33 de…
View article: Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways
Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways Open
Objective— Abdominal aortic aneurysm (AAA) is an increasingly prevalent and ultimately fatal disease with no effective pharmacological treatment. Because matrix degradation induced by vascular inflammation is the major pathophysiology of A…
View article: Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model
Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model Open
miR-126 NP-conjugated stents significantly inhibited the development of neointimal hyperplasia in rabbits. The present study may indicate the possibility of a novel therapeutic option to prevent restenosis after angioplasty.
View article: MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol
MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol Open
Rationale: Heart failure and atherosclerosis share the underlying mechanisms of chronic inflammation followed by fibrosis. A highly conserved microRNA (miR), miR-33, is considered as a potential therapeutic target for atherosclerosis becau…
View article: Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery
Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery Open
Our results suggested that miR-423-5p is enriched in PF, and serum miR-423-5p may be associate with uAP. Its expression pattern was different to that of muscle- and vascular-enriched miRNAs, miR-133a, miR-126, and miR-92a.