Hao Chen
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View article: Comparison of Coflex dynamic stabilization with bacfuse static stabilization for lumbar degenerative disease
Comparison of Coflex dynamic stabilization with bacfuse static stabilization for lumbar degenerative disease Open
View article: In Silico Comparison of Photon Versus Proton Based Stereotactic Body Radiotherapy With Increasing Maximum Peak Dose for Treatment of Primary Renal Cell Carcinoma
In Silico Comparison of Photon Versus Proton Based Stereotactic Body Radiotherapy With Increasing Maximum Peak Dose for Treatment of Primary Renal Cell Carcinoma Open
View article: Development of a High‐Resolution <scp>MNP</scp> Marker System for Aquatic Biodiversity Monitoring: A Case Study With <scp> <i>Schizothorax prenanti</i> </scp> in the Yangtze River
Development of a High‐Resolution <span>MNP</span> Marker System for Aquatic Biodiversity Monitoring: A Case Study With <span> <i>Schizothorax prenanti</i> </span> in the Yangtze River Open
Effective monitoring of aquatic biodiversity is critical for conservation, yet current approaches such as mitochondrial COI barcoding and microsatellite markers exhibit limitations in resolution, sensitivity, and scalability, particularly …
View article: Genetic Monitoring of the Endangered Acipenser dabryanus Using a High-Resolution MNP System
Genetic Monitoring of the Endangered Acipenser dabryanus Using a High-Resolution MNP System Open
Acipenser dabryanus, once abundant in China’s freshwater ecosystems, is now extinct in the wild. Effective genetic tools are urgently needed to support conservation efforts under the Yangtze River Protection Law and the 10-year fishing ban…
View article: 177Lu-Dotatate versus high-dose long-acting octreotide for the treatment of patients with advanced, grade 1-2, well-differentiated gastroenteropancreatic neuroendocrine tumours (XT-XTR008-3-01): an open-label, randomised, phase III trial
177Lu-Dotatate versus high-dose long-acting octreotide for the treatment of patients with advanced, grade 1-2, well-differentiated gastroenteropancreatic neuroendocrine tumours (XT-XTR008-3-01): an open-label, randomised, phase III trial Open
View article: Stemness-based gastric cancer classification by machine learning for precision diagnosis and treatment of gastric cancer
Stemness-based gastric cancer classification by machine learning for precision diagnosis and treatment of gastric cancer Open
Our machine learning approach performed an overall analysis of the relationship between the stemness of GC and the therapeutic effect, identified a promising stemness-based classification of GC to predict prognosis and treatment efficacy, …
View article: Altered expression spectrum and target gene prediction of tRNA-derived small RNAs in clear cell renal cell carcinoma
Altered expression spectrum and target gene prediction of tRNA-derived small RNAs in clear cell renal cell carcinoma Open
View article: Sepsis following hysteroscopic removal of retained products of conception: A case report and literature review
Sepsis following hysteroscopic removal of retained products of conception: A case report and literature review Open
Rationale: Sepsis following hysteroscopy is an rare complication, with current evidence suggesting that routine prophylactic antibiotic administration may not be warranted. However, this does not imply that we should disregard vigilance re…
View article: Clinical application of single-position prone retroperitoneal robotic-assisted laparoscopic radical nephroureterectomy with bladder cuff excision: Outcomes and techniques
Clinical application of single-position prone retroperitoneal robotic-assisted laparoscopic radical nephroureterectomy with bladder cuff excision: Outcomes and techniques Open
View article: What Is The Future Of Auction Catalogue Collecting In Museum Libraries?
What Is The Future Of Auction Catalogue Collecting In Museum Libraries? Open
Since the COVID-19 pandemic in 2020, auction houses have largely shifted from printed catalogs to online publications, impacting transparency in the art market and challenging institutional archiving. The National Gallery of Art (NGA) Libr…
View article: Knowledge Transfer Programme at TAR UMT: Evaluating Learning Outcomes through a Structured Workshop
Knowledge Transfer Programme at TAR UMT: Evaluating Learning Outcomes through a Structured Workshop Open
View article: Clinical efficacy of unilateral biportal endoscopic technique for adjacent segment pathology following lumbar fusion
Clinical efficacy of unilateral biportal endoscopic technique for adjacent segment pathology following lumbar fusion Open
View article: Prospective phase II study of stereotactic body proton therapy for treatment of primary renal cell carcinoma (SPARE): clinical trial protocol
Prospective phase II study of stereotactic body proton therapy for treatment of primary renal cell carcinoma (SPARE): clinical trial protocol Open
Background The incidence of kidney cancer diagnosis has been increasing over the last years. Surgical resection and local ablation are primary treatment options for localized disease. However, many patients are deemed medically inoperable,…
View article: Micro‐LED Retinal Projection for Augmented Reality Near‐Eye Displays (Laser Photonics Rev. 19(14)/2025)
Micro‐LED Retinal Projection for Augmented Reality Near‐Eye Displays (Laser Photonics Rev. 19(14)/2025) Open
View article: VfSCD enhances cold resistance of tung tree through a previously uncovered synthesis pathway of unsaturated fatty acids
VfSCD enhances cold resistance of tung tree through a previously uncovered synthesis pathway of unsaturated fatty acids Open
View article: Revisiting End-to-End Learning with Slide-level Supervision in Computational Pathology
Revisiting End-to-End Learning with Slide-level Supervision in Computational Pathology Open
Pre-trained encoders for offline feature extraction followed by multiple instance learning (MIL) aggregators have become the dominant paradigm in computational pathology (CPath), benefiting cancer diagnosis and prognosis. However, performa…
View article: PathBench: A comprehensive comparison benchmark for pathology foundation models towards precision oncology
PathBench: A comprehensive comparison benchmark for pathology foundation models towards precision oncology Open
The emergence of pathology foundation models has revolutionized computational histopathology, enabling highly accurate, generalized whole-slide image analysis for improved cancer diagnosis, and prognosis assessment. While these models show…
View article: Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders Open
Uniform testicular maturation arrest is a severe form of male infertility characterized by the presence of germ cells that do not complete spermatogenic development. It is usually caused by meiotic arrest with genetic variants and difficul…
View article: Rechallenge of anti‑PD‑1 antibody combined with chemotherapy shows promising efficacy in the treatment of advanced metastatic hepatocellular carcinoma: A case report
Rechallenge of anti‑PD‑1 antibody combined with chemotherapy shows promising efficacy in the treatment of advanced metastatic hepatocellular carcinoma: A case report Open
This report presents the case of a 53-year-old man who was diagnosed with hepatocellular carcinoma and developed lung metastasis after undergoing surgery and interventional treatment. The lung metastasis progressed multiple times while the…
View article: Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24‐Induced Ubiquitination of Paired Box 6
Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24‐Induced Ubiquitination of Paired Box 6 Open
This research aims to elucidate the mechanistic role of artesunate (ART) in enhancing the sensitivity of renal cell carcinoma (RCC) to sunitinib. To establish sunitinib‐resistant RCC cell lines (786‐O R and Caki‐1 R), cells were treated wi…
View article: Expression Characteristics of 3-Marker Panel (PAX2, PTEN, and β-Catenin) in Benign Interval and Secretory Endometrium and Secretory Endometrial Precancer
Expression Characteristics of 3-Marker Panel (PAX2, PTEN, and β-Catenin) in Benign Interval and Secretory Endometrium and Secretory Endometrial Precancer Open
Background/Objectives: Despite advancements in treatment options, endometrial cancer remains a significant threat to women, underscoring the importance of early detection of atypical hyperplasia/endometrioid intraepithelial neoplasia (AH/E…
View article: Reshaping the hierarchical medical system for rare diseases: a two-tier structure and one-stop referral network
Reshaping the hierarchical medical system for rare diseases: a two-tier structure and one-stop referral network Open
View article: Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study
Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study Open
To date, there remains a paucity of prospective studies examining the association between premature ovarian insufficiency (POI) and cardiovascular diseases (CVD). The objective of this study was to investigate the potential association bet…
View article: Comparison of Proton Versus Photon SBRT for Treatment of Spinal Metastases Using Variable RBE Models
Comparison of Proton Versus Photon SBRT for Treatment of Spinal Metastases Using Variable RBE Models Open
View article: A BPTF-specific PROTAC degrader enhances NK cell-based cancer immunotherapy
A BPTF-specific PROTAC degrader enhances NK cell-based cancer immunotherapy Open
Natural killer (NK) cell-based immunotherapy shows promise in cancer treatment, but its efficacy remains limited, necessitating the development of novel strategies. In this study, we demonstrate that the epigenetic factor bromodomain PHD-f…
View article: Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation
Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation Open
ABMR episodes worsened the long-term prognosis of transplanted kidneys. pericyte dysfunction appears to be one of the crucial causes of poor prognosis in ABMR patients. In vitro studies demonstrated that dysfunction of microvascular…
View article: A novel machine learning-driven immunogenic cell death signature for predicting ovarian cancer prognosis
A novel machine learning-driven immunogenic cell death signature for predicting ovarian cancer prognosis Open
The ICDRS presents a significant advancement for prognostication of patients with OC, facilitating refined predictions and the exploration of personalized treatment pathways. Prospective clinical trials are necessary to validate its clinic…
View article: Picachv: Formally Verified Data Use Policy Enforcement for Secure Data Analytics
Picachv: Formally Verified Data Use Policy Enforcement for Secure Data Analytics Open
Ensuring the proper use of sensitive data in analytics under complex privacy policies is an increasingly critical challenge. Many existing approaches lack portability, verifiability, and scalability across diverse data processing framework…
View article: Fibroblast Growth Factor 19 Disrupts Cartilage Development Via the FGFR4/β-catenin Axis.
Fibroblast Growth Factor 19 Disrupts Cartilage Development Via the FGFR4/β-catenin Axis. Open
Fibroblast growth factor 19 (FGF19) has received increasing attention in metabolic disorders of the skeletal system, but its role in cartilage development is poorly understood. In the present study, we used ex vivo metatarsal organ …
View article: Integrative Genomic and Transcriptomic Analyses Uncover Regulatory Landscape of Symbiotic Nitrogen Fixation in Soybean Natural Population
Integrative Genomic and Transcriptomic Analyses Uncover Regulatory Landscape of Symbiotic Nitrogen Fixation in Soybean Natural Population Open