Yi‐Qun Che
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View article: The Impact of Internal Nourishing Qigong Combined with Acupoint Application on Anxiety and Depression in Gastrointestinal Cancer Patients Undergoing Chemotherapy
The Impact of Internal Nourishing Qigong Combined with Acupoint Application on Anxiety and Depression in Gastrointestinal Cancer Patients Undergoing Chemotherapy Open
Objective: To explore the intervention effect of internal nourishing qigong combined with acupoint application on anxiety and depression in patients undergoing chemotherapy for gastrointestinal tumors. Methods: A total of 144 patients with…
View article: IGFBP3 Enhances Treatment Outcome and Predicts Favorable Prognosis in ABC-DLBCL
IGFBP3 Enhances Treatment Outcome and Predicts Favorable Prognosis in ABC-DLBCL Open
Chemoresistance is a key obstacle in the clinical treatment and management of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL), which leads to the poor prognosis of patients. Exploring novel biomarkers to early warn drug res…
View article: Prognostic significance of YAP1 expression and its association with neuroendocrine markers in resected pulmonary large cell neuroendocrine carcinoma (LCNEC)
Prognostic significance of YAP1 expression and its association with neuroendocrine markers in resected pulmonary large cell neuroendocrine carcinoma (LCNEC) Open
YAP1 was found to be conversely correlated with neuroendocrine markers and a prognostic factor for worse survival in resected LCNEC patients, and mechanisms need to be further investigated.
View article: Combination of Endogenous Estradiol and Adipokine Leptin in Breast Cancer Risk and Prognosis Assessment in Postmenopausal Chinese Women
Combination of Endogenous Estradiol and Adipokine Leptin in Breast Cancer Risk and Prognosis Assessment in Postmenopausal Chinese Women Open
Objective Our study aims to clarify the role of estradiol and leptin in breast cancer risk and prognostic assessment in postmenopausal Chinese women. Design The serum circulating estradiol and leptin level was detected by ELISA. Then the c…
View article: Development of a novel five‐lncRNA prognostic signature for predicting overall survival in elderly patients with breast cancer
Development of a novel five‐lncRNA prognostic signature for predicting overall survival in elderly patients with breast cancer Open
Background Breast cancer (BC) is an age‐related disease. Long noncoding RNAs (lncRNAs) have been proven to be crucial contributors in tumorigenesis. This study aims to develop a novel lncRNA‐based signature to predict elderly BC patients’ …
View article: Serum KLKB1 as a Potential Prognostic Biomarker for Hepatocellular Carcinoma Based on Data-Independent Acquisition and Parallel Reaction Monitoring
Serum KLKB1 as a Potential Prognostic Biomarker for Hepatocellular Carcinoma Based on Data-Independent Acquisition and Parallel Reaction Monitoring Open
Aberrant expression of KLKB1 was strongly associated with the prognosis of HCC patients. KLKB1 may be used to evaluate the prognosis and guide the treatment for HCC.
View article: Overexpression of LINC00673 Promotes the Proliferation of Cervical Cancer Cells
Overexpression of LINC00673 Promotes the Proliferation of Cervical Cancer Cells Open
Objective To study the expression of LINC00673 in cervical cancer and cervical intraepithelial neoplasia (CIN) and to explore the role of LINC00673 in the development of cervical cancer. Methods The expression of LINC00673 in serum from ce…
View article: CD24 Contributes to Treatment Effect in ABC-DLBCL Patients with R-CHOP Resistance
CD24 Contributes to Treatment Effect in ABC-DLBCL Patients with R-CHOP Resistance Open
CD24 was correlated with better R-CHOP treatment response and tumor immunosuppression in ABC-DLBCL. CD24 may be a promising signal in treatment and prognosis evaluation in ABC-DLBCL patients.
View article: <p>Serum lncRNAs (CCAT2, LINC01133, LINC00511) with Squamous Cell Carcinoma Antigen Panel as Novel Non-Invasive Biomarkers for Detection of Cervical Squamous Carcinoma</p>
Serum lncRNAs (CCAT2, LINC01133, LINC00511) with Squamous Cell Carcinoma Antigen Panel as Novel Non-Invasive Biomarkers for Detection of Cervical Squamous Carcinoma Open
The serum lncRNAs (CCAT2, LINC01133, and LINC00511) and SCC may be new non-invasive biomarkers for the diagnosis of CESC.
View article: <p>Depth of Response and Early Tumor Shrinkage for Predicting Clinical Outcomes in HER2-Positive Metastatic Breast Cancer Treated with Trastuzumab</p>
Depth of Response and Early Tumor Shrinkage for Predicting Clinical Outcomes in HER2-Positive Metastatic Breast Cancer Treated with Trastuzumab Open
ETS≥30% and DepRe≥40% were significant predictors of better clinical outcomes in mBC patients treated with first-line trastuzumab-based chemotherapy. Further validation in prospective trials with larger patient populations is needed.
View article: Rapid identification of novel independent serum biomarkers in diffuse large B-cell lymphoma
Rapid identification of novel independent serum biomarkers in diffuse large B-cell lymphoma Open
The potential independent serum biomarkers for diagnosis as well as prognosis of DLBCL could be provided for rapid identification.
View article: CCND2 mRNA Expression Is Correlated With R-CHOP Treatment Efficacy and Prognosis in Patients With ABC-DLBCL
CCND2 mRNA Expression Is Correlated With R-CHOP Treatment Efficacy and Prognosis in Patients With ABC-DLBCL Open
In this study we investigated whether the expression of cyclin D2 (CCND2) mRNA in activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) was correlated with the efficacy of Rituximab combined with chemotherapy (R-CHOP) treatment a…
View article: <p>Eradication of Hepatitis C Virus (HCV) Improves Survival of Hepatocellular Carcinoma Patients with Active HCV Infection – A Real-World Cohort Study</p>
Eradication of Hepatitis C Virus (HCV) Improves Survival of Hepatocellular Carcinoma Patients with Active HCV Infection – A Real-World Cohort Study Open
Our results ensured that the elimination of HCV substantially improved OS in HCC patients with active HCV infection, and the prognosis of those patients without antiviral therapy was poor.
View article: Peer Review #1 of "Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing (v0.2)"
Peer Review #1 of "Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing (v0.2)" Open
Background.Anthracycline-induced liver injury (AILI) is one of the serious complications of anthracycline-based adjuvant chemotherapy for postoperative breast cancer patients.Exosomal miRNAs, as signaling molecules in intercellular communi…
View article: Peer Review #2 of "Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing (v0.1)"
Peer Review #2 of "Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing (v0.1)" Open
Background.Anthracycline-induced liver injury (AILI) is one of the serious complications of anthracycline-based adjuvant chemotherapy for postoperative breast cancer patients.Exosomal miRNAs, as signaling molecules in intercellular communi…
View article: Peer Review #1 of "Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing (v0.1)"
Peer Review #1 of "Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing (v0.1)" Open
Background.Anthracycline-induced liver injury (AILI) is one of the serious complications of anthracycline-based adjuvant chemotherapy for postoperative breast cancer patients.Exosomal miRNAs, as signaling molecules in intercellular communi…
View article: Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing
Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing Open
Background Anthracycline-induced liver injury (AILI) is one of the serious complications of anthracycline-based adjuvant chemotherapy for postoperative breast cancer patients. Exosomal miRNAs, as signaling molecules in intercellular commun…
View article: Peer Review #2 of "Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing (v0.2)"
Peer Review #2 of "Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing (v0.2)" Open
Background.Anthracycline-induced liver injury (AILI) is one of the serious complications of anthracycline-based adjuvant chemotherapy for postoperative breast cancer patients.Exosomal miRNAs, as signaling molecules in intercellular communi…
View article: <p>Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab</p>
Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab Open
Our data indicate that baseline ALC value of ≤1 G/L is a predictor of poor outcomes, but not of response, in patients with MBC treated with trastuzumab.
View article: Tumor Mutation Load: A Novel Independent Prognostic Factor in Stage IIIA-N2 Non-Small-Cell Lung Cancer
Tumor Mutation Load: A Novel Independent Prognostic Factor in Stage IIIA-N2 Non-Small-Cell Lung Cancer Open
This study is aimed at investigating the prognostic biomarkers of patients with stage IIIA-N2 non-small-cell lung cancer (NSCLC) and at analyzing the correlation between tumor mutation load (the frequency and number of tumor mutations) and…
View article: Quantitative magnetic resonance imaging evaluation of hepatic fat content with iron deposition: will it be disturbed?
Quantitative magnetic resonance imaging evaluation of hepatic fat content with iron deposition: will it be disturbed? Open
Objective To explore noninvasive assessment of liver fat content with iron deposition using magnetic resonance (MR) quantitative technology. Methods A water–fat phantom with iron deposition containing 63 vials with predetermined fat percen…
View article: Bone Marrow Molecular Markers Associated with Relapsed/Refractory Activated B-Cell-Like Diffuse Large B-Cell Lymphoma
Bone Marrow Molecular Markers Associated with Relapsed/Refractory Activated B-Cell-Like Diffuse Large B-Cell Lymphoma Open
Activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) is a common subtype of non-Hodgkin’s lymphoma and is very likely to infiltrate the bone marrow. Over 30% of patients are converted to relapsed/refractory DLBCL after first-lin…
View article: Expression and clinical significance of programmed death ligand 1 in nasopharyngeal carcinoma
Expression and clinical significance of programmed death ligand 1 in nasopharyngeal carcinoma Open
Nasopharyngeal carcinoma (NPC) has the highest incidence of all types of head and neck cancer in China. The present study aimed to investigate the association between the expression of programmed death ligand 1 (PD-L1) in NPC tissues and c…
View article: [Clinical Analysis of Small Cell Lung Cancer with Bone Marrow Metastases].
[Clinical Analysis of Small Cell Lung Cancer with Bone Marrow Metastases]. Open
The SCLC patients with bone marrow metastasis have short survival, whereas chemotherapy can extend the survival of patients.
View article: Overexpression of S100A14 contributes to malignant progression and predicts poor prognosis of lung adenocarcinoma
Overexpression of S100A14 contributes to malignant progression and predicts poor prognosis of lung adenocarcinoma Open
Background S100A14 is a member of the S100 calcium‐binding protein family that exerts important phenotypic effects on cell proliferation, apoptosis, differentiation, and motility. However, the functional role and potential clinical signifi…
View article: Correlation analysis of mesenchymal–epithelial transition factor protein and human epidermal growth receptor 2 protein expression in 1479 cases of lung adenocarcinoma in China
Correlation analysis of mesenchymal–epithelial transition factor protein and human epidermal growth receptor 2 protein expression in 1479 cases of lung adenocarcinoma in China Open
Background To investigate the correlation between mesenchymal–epithelial transition factor (C‐Met) and human epidermal growth receptor 2 (HER2) protein expression in primary lung adenocarcinoma tissues. Method A total of 1479 resected prim…