Yuyuan Zhang
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View article: Global burden of disease analysis of stroke due to high systolic blood pressure in different regions, 1990–2021
Global burden of disease analysis of stroke due to high systolic blood pressure in different regions, 1990–2021 Open
View article: Cancer-associated fibroblasts enhance colorectal cancer lymphatic metastasis via CLEC11A/LGR5-mediated WNT pathway activation
Cancer-associated fibroblasts enhance colorectal cancer lymphatic metastasis via CLEC11A/LGR5-mediated WNT pathway activation Open
Hypoxia in the tumor microenvironment promotes lymphatic metastasis, yet the role of cancer-associated fibroblasts (CAFs) in this process remains insufficiently elucidated in colorectal cancer (CRC). In this study, we developed a large lan…
View article: Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility: insights from a cross-sectional study
Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility: insights from a cross-sectional study Open
The findings demonstrated significant linear associations between elevated UHR levels and increased odds of female infertility. UHR may serve as a potential biomarker for infertility that requires validation. Future studies should remedy t…
View article: Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy
Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy Open
View article: Correction: THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer
Correction: THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer Open
View article: Genome‐Scale CRISPR‐Cas9 Analysis Reveals Tumor Heterogeneity and Identifies NDC80 as Novel Biomarker in HCC
Genome‐Scale CRISPR‐Cas9 Analysis Reveals Tumor Heterogeneity and Identifies NDC80 as Novel Biomarker in HCC Open
Background and Aims Hepatocellular carcinoma (HCC) is a malignant tumor with a poor prognosis and is characterized by severe intratumoral heterogeneity. Identifying key genomic features and more reliable classifications is helpful for clin…
View article: 3D Bioprinting for Engineering Organoids and Organ‐on‐a‐Chip: Developments and Applications
3D Bioprinting for Engineering Organoids and Organ‐on‐a‐Chip: Developments and Applications Open
Three‐dimensional (3D) bioprinting is a promising technology for the fabrication of complex tissue structures with bionic biological functions and stable mechanical properties. Compared to traditional two‐dimensional models and animal mode…
View article: Total and regional fat-to-muscle mass ratio and risks of pan-cancer: a prospective cohort study
Total and regional fat-to-muscle mass ratio and risks of pan-cancer: a prospective cohort study Open
Our findings suggested that both total and regional FMR may serve as potential biomarkers for assessing the risk of overall and site-specific cancers.
View article: Interactions between microbiota and innate immunity in tumor microenvironment: Novel insights into cancer progression and immunotherapy
Interactions between microbiota and innate immunity in tumor microenvironment: Novel insights into cancer progression and immunotherapy Open
View article: Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation
Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation Open
Liver metastasis remains the predominant cause of mortality in patients with colorectal cancer (CRC). Nevertheless, the mechanisms underlying the initiation of colorectal cancer liver metastasis remain poorly elucidated. During the metasta…
View article: Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential
Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential Open
Solid cancer contains a complicated communication network between cancer cells and components in the tumor microenvironment (TME), significantly influencing the progression of cancer. Exosomes function as key carriers of signaling molecule…
View article: Integrated multi-omics insight into the molecular networks of oxidative stress in triggering multiple sclerosis
Integrated multi-omics insight into the molecular networks of oxidative stress in triggering multiple sclerosis Open
View article: THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis
THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis Open
Cancer-associated fibroblasts (CAFs) display significant functional and molecular heterogeneity within the tumor microenvironment, playing diverse roles in cancer progression. Employing single-cell RNA sequencing data of colorectal cancer …
View article: FOS-driven inflammatory CAFs promote colorectal cancer liver metastasis via the SFRP1-FGFR2-HIF1 axis
FOS-driven inflammatory CAFs promote colorectal cancer liver metastasis via the SFRP1-FGFR2-HIF1 axis Open
Rationale: Cancer-associated fibroblasts (CAFs) exhibit diverse functions, yet their roles in colorectal cancer liver metastasis (CRLM) remain poorly understood. Methods: Through integrated analysis of single-cell RNA sequenc…
View article: Pharmacogenomics-based subtype decoded implications for risk stratification and immunotherapy in pancreatic adenocarcinoma
Pharmacogenomics-based subtype decoded implications for risk stratification and immunotherapy in pancreatic adenocarcinoma Open
Background With fatal malignant peculiarities and poor survival rate, outcomes of pancreatic adenocarcinoma (PAAD) were frustrated by non-response and even resistance to therapy due to heterogeneity across clinical patients. Nevertheless, …
View article: Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities Open
Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and…
View article: The Interaction Between Vasculogenic Mimicry and the Immune System: Mechanistic Insights and Dual Exploration in Cancer Therapy
The Interaction Between Vasculogenic Mimicry and the Immune System: Mechanistic Insights and Dual Exploration in Cancer Therapy Open
Vasculogenic mimicry (VM) represents a novel form of angiogenesis discovered in numerous malignant tumours in recent years. Unlike traditional angiogenesis, VM facilitates tumour blood supply independently of endothelial cells by enabling …
View article: Cooperative Game Theory-Based Optimal Scheduling Strategy for Microgrid Alliances
Cooperative Game Theory-Based Optimal Scheduling Strategy for Microgrid Alliances Open
View article: Country Heterogeneity in the Global Bond Cycle: A Foreign Investor Composition Perspective
Country Heterogeneity in the Global Bond Cycle: A Foreign Investor Composition Perspective Open
View article: THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer
THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer Open
Cancer-associated fibroblasts (CAFs) exert multiple tumor-promoting functions and are key contributors to drug resistance. The mechanisms by which specific subsets of CAFs facilitate oxaliplatin resistance in colorectal cancer (CRC) have n…
View article: Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non‐Viral <scp>CAR</scp>‐<scp>NK</scp> Cell Engineering
Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non‐Viral <span>CAR</span>‐<span>NK</span> Cell Engineering Open
The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)–transduced NK cells. These cells, pivotal in innate immunity, offer a rapid and poten…
View article: Design and Fabrication of Low-Pressure Fluid Actuators for Self-Contained Wearable Devices
Design and Fabrication of Low-Pressure Fluid Actuators for Self-Contained Wearable Devices Open
Low-pressure fluid actuators play a crucial role in various engineering systems, particularly in assisting patients with limited mobility by offering advantages such as energy efficiency and precise control. These actuators are integral to…
View article: Impact of anxiety symptoms on dialysis adherence and complication rates: A longitudinal observational study
Impact of anxiety symptoms on dialysis adherence and complication rates: A longitudinal observational study Open
BACKGROUND Anxiety is a common psychological comorbidity in patients undergoing dialysis, yet its impact on treatment adherence and complication rates remains understudied. We designed a longitudinal observational study to investigate thes…
View article: Targeting immunosenescence for improved tumor immunotherapy
Targeting immunosenescence for improved tumor immunotherapy Open
Tumor immunotherapy has significantly transformed the field of oncology over the past decade. An optimal tumor immunotherapy would ideally elicit robust innate and adaptive immune responses within tumor immune microenvironment (TIME). Unfo…
View article: Cross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma
Cross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma Open
View article: Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges
Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges Open
Background Colorectal cancer (CRC) is among the most hackneyed malignancies. Even patients with identical clinical symptoms and the same TNM stage still exhibit radically different clinical outcomes after receiving equivalent treatment reg…
View article: Correction to “Fullerene Nanorings as Nitric Oxide Radical Scavengers for Ultraviolet-Induced Cellular Injury”
Correction to “Fullerene Nanorings as Nitric Oxide Radical Scavengers for Ultraviolet-Induced Cellular Injury” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Fullerene Nanorings as Nitric Oxide Radical Scavengers for Ultraviolet-Induced Cellular Injury"Qiong ZhangQiong Zhang…
View article: Proteomics appending a complementary dimension to precision oncotherapy
Proteomics appending a complementary dimension to precision oncotherapy Open
Recent advances in high-throughput proteomic profiling technologies have facilitated the precise quantification of numerous proteins across multiple specimens concurrently. Researchers have the opportunity to comprehensively analyze the mo…
View article: Machine learning‐driven diagnostic signature provides new insights in clinical management of hypertrophic cardiomyopathy
Machine learning‐driven diagnostic signature provides new insights in clinical management of hypertrophic cardiomyopathy Open
Aims In an era of evolving diagnostic possibilities, existing diagnostic systems are not fully sufficient to promptly recognize patients with early‐stage hypertrophic cardiomyopathy (HCM) without symptomatic and instrumental features. Cons…
View article: Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application Open