Yuzo Kevorkian
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View article: <scp>Rv0500A</scp> is a transcription factor that links <i>Mycobacterium tuberculosis</i> environmental response with division and impacts host colonization
<span>Rv0500A</span> is a transcription factor that links <i>Mycobacterium tuberculosis</i> environmental response with division and impacts host colonization Open
For Mycobacterium tuberculosis (Mtb) to successfully infect a host, it must be able to adapt to changes in its microenvironment, including variations in ionic signals such as pH and chloride (Cl − ), and link these responses to its growth.…
View article: Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs
Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs Open
Sensing and response to environmental cues, such as pH and chloride (Cl − ), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have ident…
View article: The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals
The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals Open
The gastrointestinal pathogen, Clostridioides difficile, initiates infection when its metabolically dormant spore form germinates in the mammalian gut. While most spore-forming bacteria use transmembrane germinant receptors to sense nutrie…
View article: The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals.
The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals. Open
The gastrointestinal pathogen, Clostridioides difficile, initiates infection when its metabolically dormant spore form germinates in the mammalian gut. While most spore-forming bacteria use transmembrane germinant receptors to sense nutrie…
View article: Potassium response and homeostasis in Mycobacterium tuberculosis modulates environmental adaptation and is important for host colonization
Potassium response and homeostasis in Mycobacterium tuberculosis modulates environmental adaptation and is important for host colonization Open
Successful host colonization by bacteria requires sensing and response to the local ionic milieu, and coordination of responses with the maintenance of ionic homeostasis in the face of changing conditions. We previously discovered that Myc…
View article: The CspC pseudoprotease regulates germination of <i>Clostridioides difficile</i> spores in response to multiple environmental signals
The CspC pseudoprotease regulates germination of <i>Clostridioides difficile</i> spores in response to multiple environmental signals Open
The gastrointestinal pathogen, Clostridioides difficile , initiates infection when its metabolically dormant spore form germinates in the mammalian gut. While most spore-forming bacteria use transmembrane germinant receptors to sense nutri…
View article: The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression
The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression Open
SUMMARY Many viruses globally shut off host gene expression to inhibit activation of cell-intrinsic antiviral responses. However, host shutoff is not indiscriminate, since viral proteins and host proteins required for viral replication are…
View article: Revisiting the Role of Csp Family Proteins in Regulating Clostridium difficile Spore Germination
Revisiting the Role of Csp Family Proteins in Regulating Clostridium difficile Spore Germination Open
Clostridium difficile causes considerable health care-associated gastrointestinal disease that is transmitted by its metabolically dormant spore form. Upon entering the gut, C. difficile spores germinate and outgrow to produce vegetative c…