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View article: Livre blanc : Faire progresser la science des symptômes du cancer à l’échelle mondiale : perspectives et stratégies ressorties de la première réunion d’infirmières expertes en science des symptômes du cancer
Livre blanc : Faire progresser la science des symptômes du cancer à l’échelle mondiale : perspectives et stratégies ressorties de la première réunion d’infirmières expertes en science des symptômes du cancer Open
Objet : La première réunion d’infirmières expertes en science des symptômes du cancer s’est tenue les 11 et 12 octobre 2023, à Lausanne, en Suisse. Quarante infirmières chercheuses représentant sept pays ont assisté à cette réunion qui vis…
View article: Associations Between Potassium Channel Genes and the Occurrence of Palpitations in Women Prior to Breast Cancer Surgery
Associations Between Potassium Channel Genes and the Occurrence of Palpitations in Women Prior to Breast Cancer Surgery Open
While direct clinical implications cannot be made, these findings provide preliminary evidence of potential therapeutic targets.
View article: White Paper: Advancing global cancer symptom science: Insights and strategies from the Inaugural Cancer Symptom Science Expert Meeting
White Paper: Advancing global cancer symptom science: Insights and strategies from the Inaugural Cancer Symptom Science Expert Meeting Open
Purpose: The inaugural “Cancer Symptom Science Expert Meeting”, held in Lausanne, Switzerland, on October 11–12, 2023, brought together 40 nurse scientists from seven countries. The event aimed to enhance collaboration across the global sy…
View article: Study protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A mother-infant study in American Samoa
Study protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A mother-infant study in American Samoa Open
Pacific Islanders, including those in American Samoa, face a disproportionately high burden of gestational diabetes mellitus (GDM) and related sequalae of metabolic conditions. The CREBRF rs373863828 genetic variant, which is uniquely comm…
View article: Poorer Quality of Life Outcomes Are Associated with Higher Levels of Stress, Lower Levels of Resilience, and Poorer Adjustment to Cancer in Outpatients Receiving Chemotherapy
Poorer Quality of Life Outcomes Are Associated with Higher Levels of Stress, Lower Levels of Resilience, and Poorer Adjustment to Cancer in Outpatients Receiving Chemotherapy Open
Given that stress and resilience are modifiable risk factors, this information can be used by clinicians to design tailored interventions to improve patients' QOL.
View article: A Data‐Driven Epigenetic Characterization of Morning Fatigue Severity in Oncology Patients Receiving Chemotherapy: Associations With Epigenetic Age Acceleration, Blood Cell Types, and Expression‐Associated Methylation
A Data‐Driven Epigenetic Characterization of Morning Fatigue Severity in Oncology Patients Receiving Chemotherapy: Associations With Epigenetic Age Acceleration, Blood Cell Types, and Expression‐Associated Methylation Open
Background Moderate‐to‐severe fatigue commonly occurs in patients with cancer. Given the numerous roles that epigenetic processes may play in the development and severity of fatigue, the purposes of this study were to (1) use a data‐driven…
View article: GDF15 and history of pregnancy-induced nausea as predictors of treatment-induced nausea severity in women following surgery for early-stage breast cancer
GDF15 and history of pregnancy-induced nausea as predictors of treatment-induced nausea severity in women following surgery for early-stage breast cancer Open
PNV history and GDF15 genetic variants influence TIN severity in women undergoing breast cancer treatment. Identifying at-risk patients may improve symptom management. Future research should explore GDF15-targeted interventions to reduce n…
View article: Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury
Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury Open
Importance Pediatric traumatic brain injury (TBI) triggers biological changes that may differ from those observed in non-brain injuries. BDNF DNA methylation (DNAm) may serve as a novel, dynamic biomarker of the brain’s response and help i…
View article: Study Protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A Mother-Infant Study in American Samoa
Study Protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A Mother-Infant Study in American Samoa Open
Introduction Pacific Islanders, including those in American Samoa, face a disproportionately high burden of gestational diabetes mellitus (GDM) and related sequalae of metabolic conditions. The CREBRF rs373863828 genetic variant, which is …
View article: State of the “Art” in Precision Health Symptom Science Research
State of the “Art” in Precision Health Symptom Science Research Open
Precision health symptom science is a relatively young field of scientific inquiry. However, the future of precision health symptom science research is both exciting and challenging. Knowledge gained in this field will result in the identi…
View article: The Use of Biomarkers in Precision Health Symptom Science—Opportunities and Challenges
The Use of Biomarkers in Precision Health Symptom Science—Opportunities and Challenges Open
Symptom biomarker identification is inherently complex and the methods for biomarker collection, processing, measurement, and analysis are continually evolving. Therefore, symptom scientists need to form transdisciplinary teams with expert…
View article: Identifying the timing and type of inflammatory markers for potential prediction of preeclampsia in women with obesity
Identifying the timing and type of inflammatory markers for potential prediction of preeclampsia in women with obesity Open
Our results suggest that the first trimester inflammatory markers and ratios may offer utility for preeclampsia prediction. Future research should explore these associations in diverse populations and validate their clinical utility. Early…
View article: Perturbations in the neuroactive ligand-receptor interaction and renin angiotensin system pathways are associated with cancer-related cognitive impairment
Perturbations in the neuroactive ligand-receptor interaction and renin angiotensin system pathways are associated with cancer-related cognitive impairment Open
Purpose This study reports on the results from our data-driven approach that identified perturbations in neuroactive ligand-receptor interaction and renin-angiotensin system (RAS) pathways in oncology patients with and without self-reporte…
View article: Distinct Morning and Evening Fatigue Profiles in Patients With Gynecologic Cancers Receiving Chemotherapy
Distinct Morning and Evening Fatigue Profiles in Patients With Gynecologic Cancers Receiving Chemotherapy Open
Clinicians can use this information to identify higher-risk patients and develop individualized interventions for morning and evening fatigue.
View article: Greater Symptom Burden and Poorer Quality of Life Outcomes Are Associated With The Co-Occurrence of Anxiety and Depression During Cancer Chemotherapy
Greater Symptom Burden and Poorer Quality of Life Outcomes Are Associated With The Co-Occurrence of Anxiety and Depression During Cancer Chemotherapy Open
Clinicians need to perform comprehensive assessments of depression and anxiety and other common symptoms and QOL outcomes during chemotherapy. In addition, referrals for targeted interventions are needed to manage multiple symptoms and imp…
View article: Impact of Multimorbidity on Symptom Burden and Symptom Clusters in Patients Receiving Chemotherapy
Impact of Multimorbidity on Symptom Burden and Symptom Clusters in Patients Receiving Chemotherapy Open
Background Detailed information on patient characteristics and symptom burden associated with multimorbidity in oncology patients is extremely limited. Purposes were to determine the prevalence of low (≤ 2) and high (≥ 3) multimorbidity in…
View article: Unrelieved Stress, Decreased Resilience, and Disengagement Coping Strategies Are Associated With Lower Levels of Hope in Patients With Cancer
Unrelieved Stress, Decreased Resilience, and Disengagement Coping Strategies Are Associated With Lower Levels of Hope in Patients With Cancer Open
Clinicians can use this information to educate patients about interventions that can decrease stress and improve their coping abilities. Patients with cancer may benefit from having conversations with clinicians that authentically convey p…
View article: Lower Functional Status, Higher Comorbidity Burden, and Higher Levels of Stress Are Associated With Worse Joint Evening Fatigue and Depressive Symptom Profiles in Outpatients Receiving Chemotherapy
Lower Functional Status, Higher Comorbidity Burden, and Higher Levels of Stress Are Associated With Worse Joint Evening Fatigue and Depressive Symptom Profiles in Outpatients Receiving Chemotherapy Open
Significance: Evening fatigue and depressive symptoms are associated with several negative outcomes for patients with cancer. However, the contribution of BOTH fatigue and depressive symptoms to patient outcomes remains unknown. This study…
View article: Associations between DNA methylation and cognitive function in early-stage hormone receptor-positive breast cancer patients
Associations between DNA methylation and cognitive function in early-stage hormone receptor-positive breast cancer patients Open
Background Approximately one-third of breast cancer (BC) patients show poorer cognitive function (CF) before receiving adjuvant therapy compared with age-matched healthy controls. However, the biological mechanisms driving CF variation in …
View article: Symptom Network Analysis and Unsupervised Clustering of Oncology Patients Identifies Drivers of Symptom Burden and Patient Subgroups With Distinct Symptom Patterns
Symptom Network Analysis and Unsupervised Clustering of Oncology Patients Identifies Drivers of Symptom Burden and Patient Subgroups With Distinct Symptom Patterns Open
Background Interindividual variability in oncology patients' symptom experiences poses significant challenges in prioritizing symptoms for targeted intervention(s). In this study, computational approaches were used to unbiasedly characteri…
View article: Self-reported cancer-related cognitive impairment is associated with perturbed neurotransmission pathways
Self-reported cancer-related cognitive impairment is associated with perturbed neurotransmission pathways Open
Background Cancer-related cognitive impairment (CRCI) is reported by 45% of patients with cancer. Significant gaps in knowledge remain regarding the mechanisms that underlie CRCI. Objectives Using a data-driven approach, the study purpose …
View article: The National Cancer Institute clinical trials planning meeting to address gaps in observational and intervention trials for cancer-related cognitive impairment
The National Cancer Institute clinical trials planning meeting to address gaps in observational and intervention trials for cancer-related cognitive impairment Open
Cancer-related cognitive impairment is a broad term encompassing subtle cognitive problems to more severe impairment. The severity of this impairment is influenced by host, disease, and treatment factors, and the impairment affects patient…
View article: Worse Morning Energy Profiles Are Associated with Significant Levels of Stress and Decrements in Resilience in Patients Receiving Chemotherapy
Worse Morning Energy Profiles Are Associated with Significant Levels of Stress and Decrements in Resilience in Patients Receiving Chemotherapy Open
Clinicians need to assess for stress and adverse childhood experiences to develop individualized management plans to increase patients' energy levels.
View article: Associations Between Preoperative Shortness of Breath and Potassium Channels Gene Variations in Women With Breast Cancer
Associations Between Preoperative Shortness of Breath and Potassium Channels Gene Variations in Women With Breast Cancer Open
Objectives Shortness of breath is a common symptom in patients with cancer. However, the mechanisms that underlie this troublesome symptom are poorly understood. Therefore, this study aimed to determine the prevalence of and associated ris…
View article: DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast Cancer
DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast Cancer Open
Gene methylation variations were demonstrated, suggesting the genes' potential roles and two possible distinct mechanisms of cognitive function in cancer.
View article: Chronic Decrements in Energy in Women with Breast Cancer are Associated with Cytokine Gene Polymorphisms
Chronic Decrements in Energy in Women with Breast Cancer are Associated with Cytokine Gene Polymorphisms Open
Findings suggest that cytokine genes are involved in the mechanisms that underlie chronic decrements in energy in women following breast cancer surgery. Given the roles of subcutaneous and visceral adipose and thyroid tissues in metabolism…
View article: Perturbations in inflammatory pathways are associated with shortness of breath profiles in oncology patients receiving chemotherapy
Perturbations in inflammatory pathways are associated with shortness of breath profiles in oncology patients receiving chemotherapy Open
View article: Characterization of per- and polyfluoroalkyl substances (PFAS) concentrations in a community-based sample of infants from Samoa
Characterization of per- and polyfluoroalkyl substances (PFAS) concentrations in a community-based sample of infants from Samoa Open
Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with documented harmful health effects. Despite increasing research, little attention has been given to studying PFAS contamination in low- and middle-income countries,…
View article: Stability and consistency of symptom clusters in younger versus older patients receiving chemotherapy
Stability and consistency of symptom clusters in younger versus older patients receiving chemotherapy Open
Background By 2035, the number of newly diagnosed cancer cases will double and over 50% will be in older adults. Given this rapidly growing demographic, a need exists to understand how age influences oncology patients’ symptom burden. The …
View article: Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery
Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery Open
We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies of pediatric acquired brain injur…