Explanipedia

Enquête de pratique sur l'utilisation de l'antibiothérapie suspensive en France dans l'endocardite infectieuse Open

Robert Eichel, Antonio Addario, T. Lemmet, Laurène Deconinck, Florent Valour , et al. · 2025

Single- Versus Multiple-sampling Strategy for Blood Cultures in the Diagnosis of Infective Endocarditis: The Prospective Multicenter UniEndo Study Open

François Goehringer, Marc Soudant, Corentine Alauzet, Christine Selton‐Suty, Nelly Agrinier , et al. · 2025

Background Single-sampling strategy (SSS) for blood cultures (BCs) has not been evaluated in infective endocarditis (IE). We assessed the diagnostic performance of SSS versus conventional multisampling strategy (MSS) in IE diagnosis. Metho…

Real-world evidence of dalbavancin effectiveness as consolidation therapy in infective endocarditis due to Enterococcus spp. Open

Carmen Hidalgo‐Tenorio, Svetlana Sadyrbaeva-Dolgova, Eduardo Aparicio‐Minguijón, Arístides de Alarcón, Antonio Plata , et al. · 2025

DBV appears to be highly effective, safe, and cost-effective as consolidation therapy in patients with IE caused by Enterococcus spp., with minimal adverse events.

Reappraising Cladophialophora bantiana phaeohyphomycosis in France: retrospective nation-based study Open

Olivier Lortholary, Dea Garcia‐Hermoso, Aude Sturny-Leclère, Karine Sitbon, Céline Nourrisson , et al. · 2024

Santé Publique France.

Identifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study Open

Mine Filiz, Hakan Erdem, Handan Ankaralı, Edmond Puca, Yvon Ruch , et al. · 2024

Infectious Mediastinitis: A Retrospective Cohort Study Open

Thomas Lemmet, Jean‐Philippe Mazzucotelli, Olivier Collange, L. Fath, Didier Mutter , et al. · 2024

Background This study aimed to characterize the demographics, microbiology, management and treatment outcomes of mediastinitis according to the origin of the infection. Methods This retrospective observational study enrolled patients who h…

Blood Culture Negative Endocarditis; What Do Concurrent Cardiac Disorders Tell Us? Open

Mine Filiz, Hakan Erdem, Handan Ankaralı, Edmond Puca, Yvon Ruch , et al. · 2024

Purpose: Blood culture negative endocarditis (BCNE) presents diagnostic challenges, necessitating precise identification of high-risk patient cohorts. Hence, our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study incl…

One Hundred Explicit Definitions of Potentially Inappropriate Prescriptions of Antibiotics in Hospitalized Older Patients: The Results of an Expert Consensus Study Open

N. Baclet, E. Forestier, G. Gavazzi, Claire Roubaud‐Baudron, Vincent Hiernard , et al. · 2024

Background: In geriatrics, explicit criteria for potentially inappropriate prescriptions (PIPs) are useful for optimizing drug use. Objective: To produce an expert consensus on explicit definitions of antibiotic-PIPs for hospitalized older…

HIV Productively Infects Highly Differentiated and Exhausted CD4+ T Cells During AIDS Open

Clayton Faua, Axel Ursenbach, Anne Fuchs, Stéphanie Caspar, Frédéric Jegou , et al. · 2024

Background: Throughout HIV infection, productively infected cells generate billions of viral particles and are thus responsible for body-wide HIV dissemination, but their phenotype during AIDS is unknown. As AIDS is associated with immunol…

Suppressive antibiotic therapy for infectious endocarditis Open

T. Lemmet, M. Bourne-Watrin, Victor Gerber, François Danion, Axel Ursenbach , et al. · 2024

Suppressive antibiotic therapy (SAT) is a long-term antibiotic strategy at times applied when an indicated surgical management of infective endocarditis (IE) is not possible. Our aim was to describe the characteristics and outcomes of pati…

Cladophialophora Bantiana  Phaeohyphomycosis in France: A Reappraisal of Epidemiology, Therapeutic Strategy, and Outcome Open

Olivier Lortholary, Dea Garcia‐Hermoso, Aude Sturny Leclère, Karine Boukris-Sitbon, Céline Nourrisson , et al. · 2024

Case Report and Literature Review of Prosthetic Cardiovascular Mucormycosis Open

Baptiste Hoellinger, L Magnus, Yvon Ruch, Mickaël Ohana, Yves Hansmann , et al. · 2023

We report a rare case of aorto-bi-iliac prosthetic allograft mucormycosis in a 57-year-old immunocompetent patient in France. Outcome was favorable after surgery and dual antifungal therapy with liposomal amphotericin B and isavuconazole. …

Suppressive antibiotic therapy for infectious endocarditis Open

Thomas Lemmet, M. Bourne-Watrin, Victor Gerber, François Danion, Baptiste Hoellinger , et al. · 2023

Purpose: Suppressive antibiotic therapy (SAT) is a long-term antibiotic strategy sometimes used when an indicated surgical management of infective endocarditis (IE) is not possible. Our aim was to describe characteristics and outcomes of p…

Organizational Benefits of Ultra-Low-Dose Chest CT Compared to Chest Radiography in the Emergency Department for the Diagnostic Workup of Community-Acquired Pneumonia: A Real-Life Retrospective Analysis Open

Sabrina Kepka, Charlène Heimann, François Séverac, Louise Hoffbeck, Pierrick Le Borgne , et al. · 2023

Background and Objectives: Chest radiography remains the most frequently used examination in emergency departments (ED) for the diagnosis of community-acquired pneumonia (CAP), despite its poor diagnostic accuracy compared with ultra-low-d…

Cefepime vs carbapenems for treating third-generation cephalosporin-resistant AmpC β-lactamase-hyperproducing Enterobacterales bloodstream infections: a multicenter retrospective study Open

Baptiste Hoellinger, Charlotte Kaeuffer, Pierre Boyer, Nicolas Lefèbvre, Yves Hansmann , et al. · 2023

This study adds evidence in favor of the use of cefepime for treating third-generation cephalosporin-resistant ABLHE BSI in case of minimal inhibitory concentration ≤ 1 mg/l, which could spare carbapenems.

Intérêt du screening des marqueurs fongiques en unité conventionnelle chez les patients présentant une infection à SARS-CoV-2 Open

Victor Gerber, Louis Boehn, Marcela Sabou, J M Denis, A. Studer , et al. · 2023

Seasonal variation in azithromycin prescription Open

François Danion, Magali Margue, Yvon Ruch, François Séverac, Yves Hansmann · 2023

Incidence and Time-to-Onset of Carbapenemase-Producing Enterobacterales (CPE) Infections in CPE Carriers: a Retrospective Cohort Study Open

Baptiste Hoellinger, Stéphanie Deboscker, François Danion, Thierry Lavigne, François Séverac , et al. · 2022

Carbapenemase-producing Enterobacterales (CPE) infections are emerging infections and may represent a therapeutic challenge, while effective antibiotic therapy is likely to be delayed. We aimed to assess the proportion of CPE infections in…

High Incidence of Acute Kidney Injury in Patients Treated with High-Dose Amoxicillin and Cloxacillin Combination Therapy Open

Yvon Ruch, Axel Ursenbach, François Danion, Fanny Reisz, Thierry Nai , et al. · 2022

High-dose amoxicillin and cloxacillin combination therapy is recommended for the empiric treatment of selected patients with infective endocarditis despite a low level of evidence. The main objective of this study was to evaluate the renal…

Remdesivir for the treatment of hospitalised patients with COVID-19: final results from the DisCoVeRy randomised, controlled, open-label trial Open

Florence Ader, Maude Bouscambert-Duchamp, Maya Hites, Nathan Peiffer‐Smadja, Julien Poissy , et al. · 2022

Background The antiviral efficacy of remdesivir is still controversial. We aimed at evaluating its clinical effectiveness in hospitalised patients with COVID-19, with indication of oxygen and/or ventilator support. Following prior publicat…

Fungal Infections Caused by <i>Kazachstania</i> spp., Strasbourg, France, 2007–2020 Open

Charlotte Kaeuffer, Mathieu Baldacini, Tiffany Ruge, Yvon Ruch, Yves-Jean Zhu , et al. · 2022

Rare fungal pathogens are emerging as agents of invasive fungal infections. We analyzed 13 cases of fungal infections caused by Kazachstania (Arxiozyma) spp. in Strasbourg University Hospital, Strasbourg, France. Among the cases, 4 patient…

Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort Open

Raphaël Carapito, Richard Y. Li, Julie Helms, Christine Carapito, Sharvari Gujja , et al. · 2021

The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major confounding factors such as age and comorbidities, true mediators of this condition have remained elusive. We used a multi-omics analysis combined with…

The COVID-19 vaccination acceptance/hesitancy rate and its determinants among healthcare workers of 91 countries: A multicenter cross-sectional study Open

Mehrdad Askarian, Aleksandr Semenov, Ferrán Llopis, Francesca Rubulotta, Gorana Dragovac , et al. · 2021

The aim of this study was to investigate the COVID-19 vaccination acceptance rate and its determinants among healthcare workers in a multicenter study. This was a cross-sectional multi-center survey conducted from February 5 to April 29, 2…

Rapid Antigen Test Combined with Chest Computed Tomography to Rule Out COVID-19 in Patients Admitted to the Emergency Department Open

Sabrina Kepka, Mickaël Ohana, François Séverac, J. Müller, Éric Bayle , et al. · 2021

Objective: Correct and timely identification of SARS-CoV-2-positive patients is critical in the emergency department (ED) prior to admission to medical wards. Antigen-detecting rapid diagnostic tests (Ag-RDTs) are a rapid alternative to Re…

Detection of Pneumocystis jirovecii in Patients with Severe COVID-19: Diagnostic and Therapeutic Challenges Open

Victor Gerber, Yvon Ruch, Thiên‐Nga Chamaraux‐Tran, Walid Oulehri, Francis Schneider , et al. · 2021

Cases of Pneumocystis jirovecii pneumonia (PCP) in patients suffering from COVID-19 were described in patients with various comorbidities and outcomes. The diagnosis of PCP in these patients is difficult due to clinical and radiological si…

Identification of driver genes for severe forms of COVID-19 in a deeply phenotyped young patient cohort Open

Raphaël Carapito, Richard Li, Julie Helms, Christine Carapito, Sharvari Gujja , et al. · 2021

The etiopathogenesis of severe COVID-19 remains unknown. Indeed given major confounding factors (age and co-morbidities), true drivers of this condition have remained elusive. Here, we employ an unprecedented multi-omics analysis, combined…

Advantages of 18F-FDG PET/CT Imaging over Modified Duke Criteria and Clinical Presumption in Patients with Challenging Suspicion of Infective Endocarditis Open

Valentin Pretet, C. Blondet, Yvon Ruch, Matías Martínez, Soraya El Ghannudi , et al. · 2021

According to European Society of Cardiology guidelines (ESC2015) for infective endocarditis (IE) management, modified Duke criteria (mDC) are implemented with a degree of clinical suspicion degree, leading to grades such as “possible” or “…

First Case of Bacteraemia Due to Carbapenem-Resistant Bacteroides faecis Open

Charlotte Kaeuffer, Tiffany Ruge, Laure Diancourt, B. Romain, Yvon Ruch , et al. · 2021

Multidrug resistant (MDR) bacteria are increasingly observed in nosocomial and community-acquired settings. Anaerobes are no exception to this rule, but there are fewer reports of MDR in the scientific literature on anaerobes than there ar…

Correction to: Impact of 16S rDNA sequencing on clinical treatment decisions: a single center retrospective study Open

Axel Ursenbach, Frédéric Schramm, François Séverac, Yves Hansmann, Nicolas Lefèbvre , et al. · 2021

An amendment to this paper has been published and can be accessed via the original article.

Protracted SARS‐CoV‐2 pneumonia with rituximab treatment: About two cases Open

Victor Gerber, Aurélie Velay, Louis Boehn, Morgane Solis, Charlotte Kaeuffer , et al. · 2021

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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