Zeina R. Al Sayed
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View article: An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy Open
The high burden of dilated cardiomyopathy (DCM) in individuals of African descent remains incompletely explained. Here, to explore a genetic basis, we conducted a genome-wide association study in 1,802 DCM cases and 93,804 controls of Afri…
Modulation of Calcium Signaling on Demand to Decipher the Molecular Mechanisms of Primary Aldosteronism Open
BACKGROUND: Primary aldosteronism is the most common form of secondary hypertension. The most frequent genetic cause of aldosterone-producing adenomas is somatic mutations in the potassium channel KCNJ5. They affect the ion selectivity of …
12428 Modulation Of Calcium Signaling On Demand To Decipher The Molecular Mechanisms Of Primary Aldosteronism Open
Disclosure: B. Fedlaoui: None. T. Cosentino: None. Z.R. Al Sayed: None. I. Giscos-Douriez: None. J. Hulot: None. T. Simon: None. S. Baron: None. F.L. Fernandes-Rosa: None. M. Zennaro: None. S. Boulkroun: None. Primary aldosteronism (PA) is…
View article: Rod-shaped micropatterning enhances the electrophysiological maturation of cardiomyocytes derived from human induced pluripotent stem cells
Rod-shaped micropatterning enhances the electrophysiological maturation of cardiomyocytes derived from human induced pluripotent stem cells Open
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer great potential for drug screening and disease modeling. However, hiPSC-CMs remain immature compared to the adult cardiac cells. Cardiomyocytes isolated from adul…
View article: HSBP7 Rescue of a Titin Cardiomyopathy Identified by Morphological Profiling
HSBP7 Rescue of a Titin Cardiomyopathy Identified by Morphological Profiling Open
Dilated cardiomyopathy (DCM), a genetic heart disease, is a major contributor to heart failure and cardiac transplantation. Of the many genes underlying DCM, the most common cause is loss of function mutations in the sarcomeric protein tit…
Modulation of calcium signaling on demand to decipher the molecular mechanisms of primary aldosteronism Open
Primary aldosteronism (PA) is the most common form of secondary hypertension. Major advances have been made in our understanding of PA with the identification of germline and somatic mutations in ion pumps and channels. These mutations lea…
View article: CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT
CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT Open
BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions with cardiac ion chann…
View article: Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human Open
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute to both diseases, suggesting a common underlying pathop…
View article: CAVIN1-Mediated Endocytosis: A Novel Mechanism Underlying The Interindividual Variability In Drug-Induced Long QT
CAVIN1-Mediated Endocytosis: A Novel Mechanism Underlying The Interindividual Variability In Drug-Induced Long QT Open
Background Drug-induced QT prolongation (diLQT) is a feared side-effect as exposing susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions with cardiac ion channels, no…
View article: A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype
A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype Open
Brugada syndrome (BrS) is an inherited arrhythmic disease predisposing to sudden cardiac death (SCD), characterized by a typical electrocardiogram pattern that includes a J point elevation with a coved type ST segment.1 BrS is a complex ge…
View article: Human model of <i>IRX5</i> mutations reveals key role for this transcription factor in ventricular conduction
Human model of <i>IRX5</i> mutations reveals key role for this transcription factor in ventricular conduction Open
Aims Several inherited arrhythmic diseases have been linked to single gene mutations in cardiac ion channels and interacting proteins. However, the mechanisms underlying most arrhythmias, are thought to involve altered regulation of the ex…
View article: <i>RRAD</i> mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome
<i>RRAD</i> mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome Open
Aims The Brugada syndrome (BrS) is an inherited cardiac disorder predisposing to ventricular arrhythmias. Despite considerable efforts, its genetic basis and cellular mechanisms remain largely unknown. The objective of this study was to id…
578Hamamy syndrome: Deciphering the role of IRX5 transcription factor in the regulation of human cardiac electrical conduction Open
or APD prolongation but also on changes in AP shape early in the repolarisation phase.This could be explained by the differential effect of these agents on other currents e.g.L-type calcium current.