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View article: Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells
Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells Open
Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th-cell lineages, hybrid …
View article: High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells
High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells Open
Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th cell lineages, hybrid …
View article: Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells
Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells Open
Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to inflammation and subsequent atrophy of small intestinal villi, causing severe bowel discomfort and malabsorption of nutrients. The major instig…
View article: Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease
Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease Open
Celiac disease (CeD) is a complex T cell-mediated enteropathy induced by gluten. Although genome-wide association studies have identified numerous genomic regions associated with CeD, it is difficult to accurately pinpoint which genes in t…
View article: Deconvolution of bulk blood eQTL effects into immune cell subpopulations
Deconvolution of bulk blood eQTL effects into immune cell subpopulations Open
View article: Systematic prioritization of candidate genes in disease loci identifies <i>TRAFD1</i> as a master regulator of IFNγ signalling in celiac disease
Systematic prioritization of candidate genes in disease loci identifies <i>TRAFD1</i> as a master regulator of IFNγ signalling in celiac disease Open
Background Celiac disease (CeD) is a complex T cell–mediated enteropathy induced by gluten. Although genome-wide association studies have identified numerous genomic regions associated with CeD, it is difficult to accurately pinpoint which…
View article: Deconvolution of bulk blood eQTL effects into immune cell subpopulations
Deconvolution of bulk blood eQTL effects into immune cell subpopulations Open
Background Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue bio…
View article: P107 The expression and regulation of Oncostatin M and its receptor in intestinal inflammation
P107 The expression and regulation of Oncostatin M and its receptor in intestinal inflammation Open
Background Intestinal homeostasis depends on the interplay between the gut microbiota, epithelium and immune cells. A novel role of Oncostatin M (OSM), a pro-inflammatory cytokine has recently been identified in mouse and human intestinal …
View article: Additional file 3 of Deconvolution of bulk blood eQTL effects into immune cell subpopulations
Additional file 3 of Deconvolution of bulk blood eQTL effects into immune cell subpopulations Open
Additional file 3 : Supplementary Table 2: Summary statistics from Decon-eQTLs for the 16,362 whole blood eQTLs.
View article: Additional file 2 of Deconvolution of bulk blood eQTL effects into immune cell subpopulations
Additional file 2 of Deconvolution of bulk blood eQTL effects into immune cell subpopulations Open
Additional file 2 : Supplementary Table 1: Ensembl IDs and symbol names of the marker genes selected by Decon-cell for the 34 predictable circulating immune cell proportions.
View article: P085 Deep profiling of the circulating immune cell landscape in inflammatory bowel disease by mass cytometry
P085 Deep profiling of the circulating immune cell landscape in inflammatory bowel disease by mass cytometry Open
Background A complex interplay of innate and adaptive immune cells maintains intestinal homeostasis. In inflammatory bowel disease (IBD), the fragile balance between regulatory and inflammatory cell subsets breaks down. The latter are recr…
View article: Deconvolution of bulk blood eQTL effects into immune cell subpopulations
Deconvolution of bulk blood eQTL effects into immune cell subpopulations Open
Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue biopsies, whic…
View article: Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs
Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs Open